Andrew J. Prendergast
Queen Mary University of London
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Publications 166
#1Robert NtoziniH-Index: 16
#2Jaya Chandna (University of Liverpool)H-Index: 4
Last. Lawrence Hale Moulton (Johns Hopkins University)H-Index: 59
view all 13 authors...
INTRODUCTION: Exposure to maternal HIV may affect early child development (ECD), although previous studies have reported heterogeneous findings. We evaluated ECD among children who were HIV-exposed uninfected (CHEU) and children who were HIV-unexposed (CHU) recruited to the SHINE trial in rural Zimbabwe. METHODS: SHINE was a community-based cluster-randomized trial of improved infant feeding and/or improved water, sanitation and hygiene. Pregnant women were enrolled between 2012 and 2015. We ass...
1 CitationsSource
#1Faith W. Kamau (Wellcome Trust)
#2Agnes Gwela (Wellcome Trust)H-Index: 2
Last. James A. Berkley (University of Oxford)H-Index: 41
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Background: In advanced HIV, significant mortality occurs soon after starting antiretroviral treatment (ART) in low- and middle-incomes countries. Calprotectin is a biomarker of innate response to infection and inflammatory conditions. We examined the association between plasma calprotectin at initiation of ART and mortality among individuals with advanced HIV. Methods: We conducted a pilot case-cohort study among HIV infected adults and children over 5 years old with CD4 + <100/mm 3 at ART init...
#1James A Church (QMUL: Queen Mary University of London)H-Index: 7
#2Bernard ChasekwaH-Index: 12
Last. Florence D MajoH-Index: 7
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Abstract Background Oral rotavirus vaccines (RVV) have poor immunogenicity in low-income countries, for reasons that remain unclear. This study identified the determinants of RVV immunogenicity among infants in rural Zimbabwe. Methods Anti-rotavirus IgA titres were measured among a sub-group of infants enrolled in the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial (NCT01824940). SHINE was a cluster-randomized trial of improved infant and young child feeding, and improved water, sanit...
#1Ethan Gough (Johns Hopkins University)H-Index: 10
#1Ethan K. Gough (Johns Hopkins University)H-Index: 1
Last. Mark JamellH-Index: 1
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Background Environmental enteric dysfunction (EED) may be an important modifiable cause of child stunting. We described the evolution of EED biomarkers from birth to 18 months in rural Zimbabwe and tested the independent and combined effects of improved water, sanitation, and hygiene (WASH), and improved infant and young child feeding (IYCF), on EED. Methodology and findings The Sanitation Hygiene Infant Nutrition Efficacy (SHINE) trial was a 2x2 factorial cluster-randomised trial of improved IY...
1 CitationsSource
#1Ethan Gough (Johns Hopkins University)H-Index: 10
#1Ethan K. Gough (Johns Hopkins University)H-Index: 1
Last. Amee R. Manges (UBC: University of British Columbia)H-Index: 25
view all 7 authors...
ABSTRACTAntimicrobials have become a mainstay of healthcare in the past century due to their activity against pathogens. More recently, it has become clear that they can also affect health via thei...
#1Ceri Evans (QMUL: Queen Mary University of London)H-Index: 4
#2Bernard ChasekwaH-Index: 12
Last. Rebecca J. Stoltzfus (Cornell University)H-Index: 54
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BACKGROUND: Although prevention of mother-to-child transmission (PMTCT) interventions have substantially reduced vertical HIV infection in sub-Saharan Africa, mortality and growth among children who are HIV-exposed remain uncertain. METHODS: SHINE was a cluster-randomised trial of improved infant and young child feeding (IYCF) and/or water, sanitation and hygiene in two rural Zimbabwean districts with 15% antenatal HIV prevalence and >80% PMTCT coverage. Pregnant women enrolled between November ...
1 CitationsSource
#1Jaya Chandna (University of Liverpool)H-Index: 4
#2Robert NtoziniH-Index: 16
Last. Melissa Gladstone (University of Liverpool)H-Index: 18
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Introduction HIV-exposed uninfected children may be at risk of poor neurodevelopment. We aimed to test the impact of improved infant and young child feeding (IYCF) and improved water, sanitation and hygiene (WASH) on early child development (ECD) outcomes. Methods Sanitation Hygiene Infant Nutrition Efficacy was a cluster randomised 2×2 factorial trial in rural Zimbabwe NCT01824940). Pregnant women were eligible if they lived in study clusters allocated to standard-of-care (SO...
1 CitationsSource
BACKGROUND: Schistosoma haematobium is a parasitic helminth which causes urogenital pathology. The impact of urogenital schistosomiasis during pregnancy on birth outcomes and child growth is poorly understood. METHODS: Risk factors for urogenital schistosomiasis were characterized among 4,437 pregnant women enrolled in a cluster-randomised community-based trial in rural Zimbabwe. Infection was defined via urine microscopy (>/=1 S. haematobium egg) and urinalysis (haematuria). Associations betwee...
#1Catherine J. Wedderburn (Lond: University of London)H-Index: 1
#2Ceri Evans (QMUL: Queen Mary University of London)H-Index: 4
Last. Andrew J. Prendergast (QMUL: Queen Mary University of London)H-Index: 33
view all 6 authors...
Purpose of Review The population of HIV-exposed uninfected (HEU) children is expanding rapidly, and over one million HEU infants are born each year globally. Several recent studies have reported that HEU children, particularly in low- and middle-income countries, are at risk of poor outcomes, including impaired growth and neurodevelopment. However, the reasons for poor clinical outcomes amongst HEU children remain unclear.
2 CitationsSource
Background:Oral rotavirus vaccines (RVVs) are less efficacious in low-income versus high-income settings, plausibly due to more enteropathogen exposure through poor water, sanitation and hygiene (WASH). We explored associations between enteropathogens and RVV immunogenicity and evaluated the effect
1 CitationsSource