William V. Tamborlane
Yale University
EndocrinologyInsulinType 1 diabetesDiabetes mellitusMedicine
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Publications 511
#2Kellee M. MillerH-Index: 25
Last. Linda A. DiMeglioH-Index: 38
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#1Risa M. WolfH-Index: 4
#2Peiyao ChengH-Index: 15
Last. William V. TamborlaneH-Index: 86
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#1Sheila M. AlessiH-Index: 22
#2Nicole C. FosterH-Index: 16
Last. Julie WagnerH-Index: 22
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#2Jessica LeventhalH-Index: 1
Last. William V. TamborlaneH-Index: 86
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GLP-1 analogues (GLP-1a) may change sweet food preferences but the neural mechanisms are not fully understood. We studied the effect of GLP-1a on neural responses to drinking high fructose corn syrup (HFCS) using fMRI in 5 lean (LN, BMI 21kg/m2, mean age 21, A1c 5.3%) and 7 obese (OB, BMI 38, age 26, A1c 5.5%) subjects. The OB group had a second fMRI after 3-mos treatment with liraglutide 3.0 mg daily. Food intake was evaluated by dietary recall. At baseline, OB group had increased cerebral bloo...
#1Thomas Danne (MHH: Hannover Medical School)H-Index: 6
#2William V. Tamborlane (Yale University)H-Index: 86
Last. Tadej Battelino (University of Ljubljana)H-Index: 38
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OBJECTIVE To compare efficacy and safety of insulin glargine 300 units/mL (Gla-300) and 100 units/mL (Gla-100) in children and adolescents (6–17 years old) with type 1 diabetes. RESEARCH DESIGN AND METHODS EDITION JUNIOR was a noninferiority, international, open-label, two-arm, parallel-group, phase 3b trial. Participants were randomized 1:1 to Gla-300 or Gla-100, titrated to achieve fasting self-monitored plasma glucose levels of 90–130 mg/dL (5.0–7.2 mmol/L), with continuation of prior prandia...
#1Shana Rose Mencher (Yale University)
#2Anisha D. Patel (Yale University)H-Index: 2
Last. William V. Tamborlane (Yale University)H-Index: 86
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#1Delnaz RoshandelH-Index: 5
#2Zhuo Chen (City of Hope National Medical Center)H-Index: 7
Last. J. Brown-FridayH-Index: 2
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BACKGROUND: Many CpGs become hyper or hypo-methylated with age. Multiple methods have been developed by Horvath et al. to estimate DNA methylation (DNAm) age including Pan-tissue, Skin & Blood, PhenoAge, and GrimAge. Pan-tissue and Skin & Blood try to estimate chronological age in the normal population whereas PhenoAge and GrimAge use surrogate markers associated with mortality to estimate biological age and its departure from chronological age. Here, we applied Horvath's four methods to calcula...
#1Michelle A. Van Name (Yale University)H-Index: 7
#2Georgeanna J. Klingensmith (University of Colorado Denver)H-Index: 38
Last. William V. Tamborlane (Yale University)H-Index: 86
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Background: Completing phase 3 trials of new drugs for youth with type 2 diabetes is challenging. The Pediatric Diabetes Consortium (PDC) of US pediatric treatment centers developed a consortium mo...
#1Persis V. Commissariat (Joslin Diabetes Center)H-Index: 2
#2Amanda L. Whitehouse (Harvard University)H-Index: 1
Last. William V. Tamborlane (Yale University)H-Index: 86
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There are multiple information sources available to assist families in learning about rapidly advancing diabetes technologies as care options for their children. This study explored where and from ...
#1Persis V. Commissariat (Harvard University)H-Index: 2
#2Kara R. Harrington (Harvard University)H-Index: 4
Last. Lori M. Laffel (Harvard University)H-Index: 59
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BACKGROUND: Across all age groups, management of type 1 diabetes (T1D) places substantial responsibility and emotional burden upon families. This study explored parent perceptions of the burdens of caring for very young children with T1D. METHODS: Semi-structured qualitative interviews were conducted with parents (85% mothers) of 79 children with T1D, aged 1 to /=6 months: age (M +/- SD) 5.2 +/- 1.5 years, diabetes duration 2.4 +/- 1.3 years, and A1c 63 +/- 10 mmol/mol (7.9 +/- 0.9%); 66% used a...
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