Balazs Dome
Medical University of Vienna
PathologyImmunologyLung cancerCancer researchMedicine
What is this?
Publications 195
#1Agnes Bilecz (Semmelweis University)H-Index: 3
#2Paul StockhammerH-Index: 2
Last. Felicitas Oberndorfer (Medical University of Vienna)H-Index: 8
view all 22 authors...
AIMS: Malignant pleural mesothelioma (MPM) is a rare malignancy with dismal prognosis. While the epithelioid type is associated with more favorable outcome, additional factors are needed to further stratify prognosis and to identify patients who can benefit from multimodal treatment. As epithelioid MPM shows remarkable morphological variability, the prognostic role of the five defined morphologies, the impact of the nuclear grading system and the mitosis-necrosis score were investigated in this ...
#1Hui Yun Hwang (Yonsei University)H-Index: 2
#1Hui‐Yun Hwang (Yonsei University)
Last. Ho Jeong Kwon (Yonsei University)H-Index: 43
view all 7 authors...
Identifying the target proteins of bioactive small molecules is a key step in understanding mode-of-action of the drug and addressing the underlying mechanisms responsible for a particular phenotype. Proteomics has been successfully used to elucidate the target protein profiles of unmodified and ligand-modified bioactive small molecules. In the latter approach, compounds can be modified via click chemistry and combined with activity-based protein profiling. Target proteins are then enriched by p...
#1David Dora (Semmelweis University)H-Index: 2
#2Christopher J. Rivard (Anschutz Medical Campus)H-Index: 35
Last. Zsolt Megyesfalvi (Semmelweis University)H-Index: 1
view all 14 authors...
Small cell lung cancer (SCLC) has recently been sub-categorized into neuroendocrine (NE)-high and NE-low subtypes showing 9immune desert9 and 9immune oasis9 phenotypes, respectively. We aimed to characterize the immune cell localization and the microenvironment according to immune checkpoints and NE subtypes in human SCLC tissue samples at the protein level. In this cross-sectional study, we included 32 primary tumors and matched lymph node (LN) metastases of resected early-stage, histologically...
#2Sophia DerdakH-Index: 11
Last. Ivo Gut (UPF: Pompeu Fabra University)H-Index: 23
view all 27 authors...
Chronic obstructive pulmonary disease (COPD) is induced by cigarette smoking and characterized by inflammation of airway tissue. Since smokers with COPD have a higher risk of developing lung cancer than those without, we hypothesized that they carry more mutations in affected tissue. We called somatic mutations in airway brush samples from medium-coverage whole genome sequencing data from healthy never and ex-smokers (n = 8), as well as from ex-smokers with variable degrees of COPD (n = 4). Owin...
#1Julian Mohrherr (Medical University of Vienna)H-Index: 1
#2Marcel HaberH-Index: 1
Last. Emilio Casanova (Medical University of Vienna)H-Index: 24
view all 19 authors...
3 CitationsSource
#1Zoltan LohinaiH-Index: 5
#2Zsolt MegyesfalviH-Index: 1
Last. Fred R. HirschH-Index: 75
view all 10 authors...
Background: Recent preclinical data suggest that neuroendocrine (NE) subtype of small cell lung cancer (SCLC) has strong therapeutic relevance. NE high tumors are associated with immune desert and NE low tumors are considered to have an immune oasis phenotype. Our aim was to investigate the NE phenotypes of surgically resected SCLC tumors according to inter-tumor heterogeneity. Methods: Expression analysis for 2,560 genes was performed in 32 surgically resected SCLC patients’ primary tumors and ...
1 CitationsSource
#1Zoltan Lohinai (Medical University of Vienna)H-Index: 5
#2Zsolt Megyesfalvi (Semmelweis University)H-Index: 1
Last. Glen J. WeissH-Index: 35
view all 4 authors...
Abstract BACKGROUND: Molecular underpinnings that may prognosticate survival could increase understanding of small cell lung cancer (SCLC) tumor behavior. Here, we report the clinicopathological characteristics and biomarker profiles of short-term (ST) versus long-term (LT) survival in patients with metastatic SCLC. METHODS: Of the 876 consecutive metastatic SCLC patients receiving standard of care therapy, 44 met the definition of LT and 91 for ST, respectively. Available FFPE tumor tissue bloc...
1 CitationsSource
#1Stefan JanikH-Index: 5
#2Christine BekosH-Index: 6
Last. Bernhard MoserH-Index: 78
view all 11 authors...
Tumor angiogenesis is a key factor in the progression of thymic epithelial tumors (TETs). Activin A, a member of the TGFβ family, and its antagonist Follistatin are involved in several human malignancies and angiogenesis. We investigated Activin A and Follistatin in serum and tumor tissue of patients with TETs in relation to microvessel density (MVD), WHO histology classification, tumor stage and outcome. Membranous Activin A expression was detected in all tumor tissues of TETs, while Follistati...
#1Áron GhimessyH-Index: 2
Last. Balazs DomeH-Index: 28
view all 18 authors...
Bevacizumab, combined with platinum-based chemotherapy, has been widely used in the treatment of advanced-stage lung adenocarcinoma (LADC). Although KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) mutation is the most common genetic alteration in human LADC and its role in promoting angiogenesis has been well established, its prognostic and predictive role in the above setting remains unclear. The association between KRAS exon 2 mutational status and clinicopathological variables inc...
#1Dhruva Biswas (UCL: University College London)H-Index: 1
#1Dhruva Biswas (UCL: University College London)H-Index: 1
Last. Charles Swanton (UCL: University College London)H-Index: 66
view all 35 authors...
An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage1. Transcriptomic intratumor heterogeneity (RNA-ITH) has been shown to confound existing expression-based biomarkers across multiple cancer types2–6. Here, we analyze multi-region whole-exome and RNA sequencing data for 156 tumor regions from 48 patients enrolled in the TRACERx study to explore and control fo...
3 CitationsSource