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Akira Sekikawa
University of Pittsburgh
EndocrinologyCardiologyPopulationDiabetes mellitusMedicine
196Publications
27H-index
3,696Citations
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Publications 226
Newest
#1Brian Man (University of Pittsburgh)
#2Chendi Cui (University of Pittsburgh)H-Index: 2
Last. Akira Sekikawa (University of Pittsburgh)H-Index: 27
view all 6 authors...
PURPOSE Some but not all randomized controlled trials (RCTs) of soy isoflavones showed their beneficial effect on arterial stiffness, a predictor of cardiovascular events, dementia, and all-cause mortality, independent of traditional risk factors. To test the hypothesis that supplementation of soy isoflavones reduces arterial stiffness, we performed a systematic review and meta-analysis of RCTs of soy isoflavones on arterial stiffness. METHODS The protocol of this systematic review was registere...
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#1Megan M. Marron (University of Pittsburgh)H-Index: 4
#2Steven C. MooreH-Index: 41
Last. A. Newman (University of Pittsburgh)H-Index: 150
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1 CitationsSource
#1Naoko Sagawa (University of Pittsburgh)H-Index: 1
#2Bonny Rockette-Wagner (University of Pittsburgh)H-Index: 3
Last. Akira Sekikawa (University of Pittsburgh)H-Index: 27
view all 10 authors...
Abstract Background Metabolic syndrome (MetS) is a global health problem. Physical activity (PA) is a known modifiable risk factor for MetS and individual MetS components. However, the role of PA could differ between sub-populations due to differences in the variability of PA and other MetS risk factors. To examine these differences, multi-country studies with standardized outcome measurement methods across cohorts are needed. Methods Cross-sectional PA levels (total and domain-specific) in heal...
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#1Chendi Cui (University of Pittsburgh)H-Index: 2
#2Rahel L. Birru (University of Pittsburgh)H-Index: 4
Last. Akira Sekikawa (University of Pittsburgh)H-Index: 27
view all 12 authors...
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#1Hemant Mahajan (University of Pittsburgh)H-Index: 1
#2Maryam Zaid (Shiga University of Medical Science)H-Index: 8
Last. Akira Sekikawa (University of Pittsburgh)H-Index: 27
view all 14 authors...
Objective This cross-sectional study examined whether contrasting distributions of nuclear magnetic resonance (NMR)-measured lipoproteins contribute to differences in the prevalence of subclinical atherosclerosis measured using coronary artery calcium (CAC) between the two groups of middle-aged males: the US-residing Caucasian (US-White) and Japan-residing Japanese (Japanese). Methods In a population-based study of 570 randomly selected asymptomatic men aged 40–49 years (270 US-White and 300 Jap...
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#1Akira SekikawaH-Index: 27
Last. Xiao ZhangH-Index: 1
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A recent randomized controlled trial (RCT), the Reduction of Cardiovascular Events with Icosapent Ethyl-Intervention Trial (REDUCE-IT), reported that high-dose marine omega-3 fatty acids (OM3) significantly reduce cardiovascular disease (CVD) outcomes, yet the mechanisms responsible for this benefit remain unknown. To test the hypothesis that high-dose OM3 is anti-atherosclerotic, we performed a systematic review and meta-analysis of RCT of high-dose OM3 on atherosclerosis. The protocol of this ...
2 CitationsSource
#1Soshiro Ogata (Fujita Health University)H-Index: 2
#2Kunihiro NishimuraH-Index: 14
Last. Martin O'Flaherty (University of Liverpool)H-Index: 37
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Abstract Background We aimed to quantify contributions of changes in risks and uptake of evidence-based treatment to coronary heart disease (CHD) mortality trends in Japan between 1980 and 2012. Methods We conducted a modelling study for the general population of Japan aged 35 to 84 years using the validated IMPACT model incorporating data sources like Vital Statistics. The main outcome was difference in the number of observed and expected CHD deaths in 2012. Results From 1980 to 2012, age-adjus...
3 CitationsSource
#1Chendi CuiH-Index: 2
#2Zheming YuH-Index: 2
Last. Akira SekikawaH-Index: 27
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#1Akira Sekikawa (University of Pittsburgh)H-Index: 27
#2Hemant Mahajan (University of Pittsburgh)H-Index: 1
Last. Hirotsugu Ueshima (Shiga University of Medical Science)H-Index: 70
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Clinical trials of eicosapentaenoic acid (EPA) among high-risk groups in Japan in which consumption of mairne-omega-3 fatty acids (OM3) is much higher than other countries showed slower progression of coronary atherosclerosis. We aimed to determine the cross-sectional associations of coronary artery calcification (CAC) and calcium density with OM3, EPA, and docosahexaenoic acid (DHA), two principal OM3, in the general population in Japan. The Shiga Epidemiological Study of Subclinical Atheroscle...
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#1Atsushi SatohH-Index: 3
#2Hisatomi ArimaH-Index: 45
Last. Hirotsugu UeshimaH-Index: 70
view all 15 authors...
Objective:We conducted a cross-sectional study to clarify whether home blood pressure (HBP) is more strongly associated with coronary artery calcification (CAC) than accurately measured office blood pressure (OBP) among the general population of Japanese men.Methods:We analyzed the data of 919 Japan
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