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Thanos Tzounopoulos
University of Pittsburgh
33Publications
14H-index
793Citations
Publications 33
Newest
Chung-Yang Yeh1
Estimated H-index: 1
(University of Pittsburgh),
Zhaofeng Ye2
Estimated H-index: 2
(THU: Tsinghua University)
+ 9 AuthorsRajesh Khanna30
Estimated H-index: 30
(UA: University of Arizona)
The neuronal cell death-promoting loss of cytoplasmic K + following injury is mediated by an increase in Kv2.1 potassium channels in the plasma membrane. This phenomenon relies on Kv2.1 binding to syntaxin 1A via 9 amino acids within the channel intrinsically disordered C terminus. Preventing this interaction with a cell and blood-brain barrier-permeant peptide is neuroprotective in an in vivo stroke model. Here a rational approach was applied to define the key molecular interactions between syn...
Published on May 14, 2019in ACS Medicinal Chemistry Letters 3.74
Ruiting Liu1
Estimated H-index: 1
(University of Pittsburgh),
Thanos Tzounopoulos14
Estimated H-index: 14
(University of Pittsburgh),
Peter Wipf68
Estimated H-index: 68
(University of Pittsburgh)
Based on the potent Kv7 agonist RL-81, we prepared new lead structures with greatly improved selectivity for Kv7.2/Kv7.3 over related potassium channels, i.e., Kv7.3/Kv7.5, Kv7.4, and Kv7.4/7.5. RL-36 and RL-12 maintain an agonist EC2x of ca. 1 μM on Kv7.2/Kv7.3 in a high-throughput assay on an automated electrophysiology platform in HEK293 cells but lack activity on Kv7.3/Kv7.5, Kv7.4, and Kv7.4/7.5, resulting in a selectivity index SI > 10. RL-56 is remarkably potent, EC2x 0.11 ± 0.02 μM, and ...
Thanos Tzounopoulos14
Estimated H-index: 14
(University of Pittsburgh),
Carey D. Balaban35
Estimated H-index: 35
(University of Pittsburgh)
+ 1 AuthorsCatherine V. Palmer15
Estimated H-index: 15
(University of Pittsburgh)
In this position review, we propose to establish a path for replacing the empirical classification of tinnitus with a taxonomy from precision medicine. The goal of a classification system is to understand the inherent heterogeneity of individuals experiencing and suffering from tinnitus and to identify what differentiates potential subgroups. Identification of different patient subgroups with distinct audiological, psychophysical, and neurophysiological characteristics will facilitate the manage...
Published on Jan 30, 2019in The Journal of Neuroscience 6.07
Manoj Kumar2
Estimated H-index: 2
(University of Pittsburgh),
Shanshan Xiong1
Estimated H-index: 1
(CSU: Central South University)
+ 1 AuthorsCharles T. Anderson13
Estimated H-index: 13
(University of Pittsburgh)
Neurons in the auditory cortex are tuned to specific ranges of sound frequencies. Although the cellular and network mechanisms underlying neuronal sound frequency selectivity are well-studied and reflect the interplay of thalamocortical and intracortical excitatory inputs and further refinement by cortical inhibition, the precise synaptic signaling mechanisms remain less understood. To gain further understanding on these mechanisms and their effects on sound-driven behavior, we employed in vivo ...
Published on May 11, 2018in bioRxiv
Nathan W. Vogler3
Estimated H-index: 3
(University of Pittsburgh),
Thanos Tzounopoulos14
Estimated H-index: 14
(University of Pittsburgh)
In many excitatory synapses, synaptic zinc is co-released with glutamate to modulate neurotransmission. Synaptic zinc modulates the responsiveness of auditory cortex to sound, and synaptic zinc levels and signaling are modulated by sensory experience, termed zinc plasticity. The mechanisms underlying zinc plasticity remain unknown. We discovered that high- and low-frequency electrical stimulation of dorsal cochlear nucleus synapses reduces and increases synaptic zinc signaling, respectively. Thi...
Published on Feb 14, 2018in Journal of the American Chemical Society 14.70
Jacob M. Goldberg12
Estimated H-index: 12
(MIT: Massachusetts Institute of Technology),
Fang Wang2
Estimated H-index: 2
(MIT: Massachusetts Institute of Technology)
+ 5 AuthorsStephen J. Lippard116
Estimated H-index: 116
(MIT: Massachusetts Institute of Technology)
Fluorescent sensors for mobile zinc are valuable for studying complex biological systems. Because these sensors typically bind zinc rapidly and tightly, there has been little temporal control over the activity of the probe after its application to a sample. The ability to control the activity of a zinc sensor in vivo during imaging experiments would greatly improve the time resolution of the measurement. Here, we describe photoactivatable zinc sensors that can be triggered with short pulses of U...
Published on Sep 9, 2017in eLife 7.55
Charles T. Anderson13
Estimated H-index: 13
(University of Pittsburgh),
Manoj Kumar2
Estimated H-index: 2
(University of Pittsburgh)
+ 1 AuthorsThanos Tzounopoulos14
Estimated H-index: 14
(University of Pittsburgh)
Many people find it easy to follow a conversation while on a busy city street, but this seemingly simple task requires sophisticated processing of sounds. The brain must accurately distinguish speech sounds from background noise, even though the volumes and pitches of those sounds overlap. To make this possible, neurons that process sounds continually adjust the relationship between the volume of a sound and the size of their response. This helps the brain to distinguish more precisely between d...
Published on Jun 7, 2017in The Journal of Neuroscience 6.07
Chung Yang Yeh1
Estimated H-index: 1
,
Ashlyn M. Bulas1
Estimated H-index: 1
+ 7 AuthorsElias Aizenman46
Estimated H-index: 46
National Institutes of Health [NS043277, DC007905, 5T32NS007433-18]; American Heart Association [16PRE29170009]
Published on Jan 1, 2017
Bopanna I. Kalappa9
Estimated H-index: 9
(University of Pittsburgh),
Thanos Tzounopoulos14
Estimated H-index: 14
(University of Pittsburgh)
Abstract Synaptically released zinc inhibits baseline excitatory neurotransmission; however, the role of this neuromodulator on short-term plasticity during different levels of synaptic activity remains largely unknown. This lack of knowledge prevents our understanding of information transfer across zinc-releasing synapses, including 50% of excitatory synapses in cortical areas. We used in vitro electrophysiology in mouse brain slices and discovered that the effects of zinc on excitatory postsyn...
Published on Oct 27, 2016in Frontiers in Cellular Neuroscience 3.90
Cesar C. Ceballos4
Estimated H-index: 4
(USP: University of São Paulo),
Shuang Li4
Estimated H-index: 4
(University of Pittsburgh)
+ 2 AuthorsRicardo M. Leão1
Estimated H-index: 1
(USP: University of São Paulo)
In a neuronal population, several combinations of its ionic conductances are used to attain a specific firing phenotype. Some neurons present heterogeneity in their firing, generally produced by expression of a specific conductance, but how additional conductances vary along in order to homeostatically regulate membrane excitability is less known. Dorsal cochlear nucleus principal neurons, fusiform neurons, display heterogeneous spontaneous action potential activity and thus represent an appropr...
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