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Lothar Hennighausen
National Institutes of Health
Molecular biologyMammary glandSTAT5Cancer researchBiology
321Publications
89H-index
25.3kCitations
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Publications 322
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#1Lothar Hennighausen (NIH: National Institutes of Health)H-Index: 89
#2Hye-Kyung Lee (NIH: National Institutes of Health)H-Index: 13
ACE2, in concert with the protease TMPRSS2, binds the novel coronavirus SARS-CoV-2 and facilitates its cellular entry. The ACE2 gene is expressed in SARS-CoV-2 target cells, including Type II Pneumocytes (Ziegler, 2020), and is activated by interferons. Viral RNA was also detected in breast milk (Wu et al., 2020), raising the possibility that ACE2 expression is under the control of cytokines through the JAK-STAT pathway. Here we show that Ace2 expression in mammary tissue is induced during pregn...
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#1Xianke Zeng (NIH: National Institutes of Health)H-Index: 3
#2Hye-Kyung Lee (NIH: National Institutes of Health)H-Index: 13
Last. Lothar Hennighausen (NIH: National Institutes of Health)H-Index: 89
view all 6 authors...
Lineage-specific genetic programs rely on cell-restricted super-enhancers, which are platforms for high-density transcription factor occupation. It is not known whether super-enhancers synergize specifically with their native promoters or provide autonomous and independent regulatory platforms. Here, we investigated the ability of the mammary Wap super-enhancer to activate the promoter of the juxtaposed and ubiquitously expressed Tbrg4 gene in the mouse mammary gland. The Wap super-enhancer was ...
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#1Hye-Kyung Lee (NIH: National Institutes of Health)H-Index: 13
#2Harold E. Smith (NIH: National Institutes of Health)H-Index: 12
Last. Lothar Hennighausen (NIH: National Institutes of Health)H-Index: 89
view all 5 authors...
Deaminase base editing has emerged as a tool to install or correct point mutations in the genomes of living cells in a wide range of organisms. However, the genome-wide off-target effects introduced by base editors in the mammalian genome have been examined in only one study. Here, we have investigated the fidelity of cytosine base editor 4 (BE4) and adenine base editors (ABE) in mouse embryos using unbiased whole-genome sequencing of a family-based trio cohort. The same sgRNA was used for BE4 a...
3 CitationsSource
#1Hye-Kyung Lee (NIH: National Institutes of Health)H-Index: 13
#2Harold E. Smith (NIH: National Institutes of Health)H-Index: 12
Last. Lothar Hennighausen (NIH: National Institutes of Health)H-Index: 89
view all 5 authors...
Deaminase base editing has emerged as a tool to install or correct point mutations in the genomes of living cells in a wide range of organisms and its ultimate success therapeutically depends on its accuracy. Here we have investigated the fidelity of cytosine base editor 4 (BE4) and adenine base editor (ABE) in mouse embryos using unbiased whole genome sequencing of a family-based trio cohort. We demonstrate that BE4-edited mice carry an excess of single-nucleotide variants and deletions compare...
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#1Sebastian Kollmann (University of Veterinary Medicine Vienna)H-Index: 2
#2Eva Grundschober (University of Veterinary Medicine Vienna)H-Index: 6
Last. Veronika Sexl (University of Veterinary Medicine Vienna)H-Index: 37
view all 16 authors...
Deregulation of the Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling pathway is found in cancer with STAT5A/B controlling leukemic cell survival and disease progression. As mutations in STAT5B, but not STAT5A, have been frequently described in hematopoietic tumors, we used BCR/ABL as model systems to investigate the contribution of STAT5A or STAT5B for leukemogenesis. The absence of STAT5A decreased cell survival and colony formation. Even more drastic effects...
2 CitationsSource
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#1Dana Lau-Corona (BU: Boston University)H-Index: 2
#2Woo Kyun Bae (NIH: National Institutes of Health)H-Index: 15
Last. David J. Waxman (BU: Boston University)H-Index: 76
view all 4 authors...
Background: Sex differences in the incidence and progression of many liver diseases, including liver fibrosis and hepatocellular carcinoma, are associated with sex-biased expression of hundreds of genes in the liver. This sexual dimorphism is largely determined by the sex-specific pattern of pituitary growth hormone secretion, which controls a transcriptional regulatory network operative in the context of sex-biased chromatin states. Histone H3K27-trimethylation yields a major sex-biased repress...
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#1Ha Youn Shin (Konkuk University)H-Index: 6
#2Lothar Hennighausen (Sookmyung Women's University)H-Index: 89
Last. Kyung Hyun Yoo (Sookmyung Women's University)H-Index: 14
view all 3 authors...
The de novo formation of milk-secreting mammary epithelium during pregnancy is regulated by prolactin through activation of the transcription factor STAT5, which stimulates the expression of several hundred mammary-specific genes. In addition to its key role in activating gene expression in mammary tissue, STAT5, which is ubiquitously expressed in most cell types, implements T cell-specific programs controlled by interleukins. However, the mechanisms by which STAT5 controls cell-specific genetic...
3 CitationsSource
#1Kyung Hyun Yoo (Sookmyung Women's University)H-Index: 14
#2Lothar Hennighausen (Sookmyung Women's University)H-Index: 89
Last. Ha Youn Shin (Konkuk University)H-Index: 6
view all 3 authors...
Recent advances in genome-wide sequencing technologies have provided researchers with unprecedented opportunities to discover the genomic structures of gene regulatory units in living organisms. In particular, the integration of ChIP-seq, RNA-seq, and DNase-seq techniques has facilitated the mapping of a new class of regulatory elements. These elements, called super-enhancers, can regulate cell-type-specific gene sets and even fine-tune gene expression regulation in response to external stimuli,...
1 CitationsSource
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