Mitsutoshi Setou
Hamamatsu University
Publications 356
#1Makoto Nampei (Hamamatsu University)
#2Makoto Horikawa (Hamamatsu University)H-Index: 7
Last.Mitsutoshi Setou (Hamamatsu University)H-Index: 50
view all 7 authors...
Current histological and anatomical analysis techniques, including fluorescence in situ hybridisation, immunohistochemistry, immunofluorescence, immunoelectron microscopy and fluorescent fusion protein, have revealed great distribution diversity of mRNA and proteins in the brain. However, the distributional pattern of small biomolecules, such as lipids, remains unclear. To this end, we have developed and optimised imaging mass spectrometry (IMS), a combined technique incorporating mass spectrome...
#1Emiko TakeyamaH-Index: 2
Last.Mitsutoshi SetouH-Index: 50
view all 13 authors...
Docosahexaenoic acid (DHA), an omega-3 polyunsaturated fatty acid, has significant health benefits. Previous studies reported decreased levels of DHA and DHA-containing phosphatidylcholines in the brain of animals suffering from Alzheimer’s disease, the most common type of dementia; furthermore, DHA supplementation has been found to improve brain DHA levels and memory efficiency in dementia. Oil extracted from the seeds of Plukenetia volubilis (green nut oil; GNO) is also expected to have DHA li...
#1Md. Al Mamun (Hamamatsu University)
Last.Mitsutoshi Setou (Hamamatsu University)H-Index: 50
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Abstract Aging has been established as a major risk factor for prevalent diseases and hence, the development of anti-aging medicines is of great importance. Recently, herbal fermented beverages have emerged as a promising source of potential anti-aging drug. Pru, a traditional Cuban refreshment produced by decoction and fermentation of multispecies plants with sugar, has been consumed for many years and is claimed to have multiple medicinal properties. Besides the traditional method, Pru is also...
#1Eiji Sugiyama (Keio: Keio University)H-Index: 8
#2Matteo M. GuerriniH-Index: 1
Last.Yuki Sugiura (Keio: Keio University)H-Index: 24
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Summary Monoamine neurotransmitters are released by specialized neurons regulating behavioral, motor, and cognitive functions. Although the localization of monoaminergic neurons in the brain is well known, the distribution and kinetics of monoamines remain unclear. Here, we generated a murine brain atlas of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) levels using mass spectrometry imaging (MSI). We found several nuclei rich in both 5-HT and a catecholamine (DA or NE) and identified ...
#1Kodai Hino (Shiga University of Medical Science)H-Index: 2
#2Shunya Kaneko (Shiga University of Medical Science)
Last.Jun Udagawa (Shiga University of Medical Science)H-Index: 17
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Epidemiological studies suggest that poor nutrition during pregnancy influences offspring predisposition to experience developmental and psychiatric disorders. Animal studies have shown that maternal undernutrition leads to behavioral impairment, which is linked to alterations in monoaminergic systems and inflammation in the brain. In this study, we focused on the ethanolamine plasmalogen of the brain as a possible contributor to behavioral disturbances observed in offspring exposed to maternal ...
#1Tomohito Sato (Hamamatsu University)H-Index: 2
#2Makoto Horikawa (Hamamatsu University)H-Index: 7
Last.Mitsutoshi Setou (Hamamatsu University)H-Index: 50
view all 17 authors...
Objective: n-3 polyunsaturated fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have beneficial effects on atherosclerosis. Although specific salutary actions hav...
#1Satoru Furuhashi (Hamamatsu University)H-Index: 1
#2Takanori Sakaguchi (Hamamatsu University)H-Index: 23
Last.Hiyoya Takeuchi (Hamamatsu University)
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Background: Perineural invasion (PNI) is commonly seen in pancreatic ductal adenocarcinoma (PDAC) and worsens the postoperative prognosis. However, the associated mechanisms in cancer progression remain unclear. Tenascin C (TNC), an extracellular matrix glycoprotein, is abundant in cancer stroma and modulates tumor progression. The aim of this study was to evaluate the functional roles of TNC in the neural microenvironment of PDAC. Methods: We immunohistochemically examined TNC expression in 78 ...
#1Fuka Aizawa (Kobe Gakuin University)H-Index: 6
#2Shumpei Sato (Hamamatsu University)H-Index: 2
Last.Shogo Tokuyama (Kobe Gakuin University)H-Index: 23
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Abstract N-3 fatty acids, including docosahexaenoic acid (DHA), have a beneficial effect in both pain and psychiatric disorders. In fact, we previously reported that stress-induced pain prolongation might be mediated through the suppression of the G-protein coupled-receptor 40/free fatty acid receptor 1 (GPR40/FFAR1), which is activated by DHA and long-chain fatty acids. However, the involvement of GPR40/FFAR1 ligands in the development of stress-induced chronic pain has not yet been described. ...
#1Yuko Nakashima (Hamamatsu University)H-Index: 2
#2Hiroka Sato (Hamamatsu University)
Last.Mitsutoshi Setou (Hamamatsu University)H-Index: 50
view all 4 authors...