Hugo A. Katus
Heidelberg University
CardiologyHeart failureMyocardial infarctionDiabetes mellitusMedicine
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Publications 1952
#1Ann-Kathrin Rahm (University Hospital Heidelberg)H-Index: 7
#2Mara Elena Müller (Heidelberg University)
Last. Tanja Heimberger (University Hospital Heidelberg)
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Transient outward K(+) current, Ito, contributes to cardiac action potential generation and is primarily carried by Kv4.3 (KCND3) channels. Two Kv4.3 isoforms are expressed in human ventricle and show differential remodeling in heart failure (HF). Lidocaine and mexiletine may be applied in selected patients to suppress ventricular arrhythmias, without effects on sudden cardiac death or mortality. Isoform-dependent effects of antiarrhythmic drugs on Kv4.3 channels and potential implications for r...
#1Nicole Lossnitzer (Heidelberg University)H-Index: 6
#2Manuel Feisst (Heidelberg University)H-Index: 1
Last. Christian Stock (Heidelberg University)H-Index: 21
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BACKGROUND Depression is common in patients with chronic heart failure (CHF) and is a predictor of rehospitalization and mortality. However, the complex bidirectional relationships between these two conditions are barely understood. We investigated the course of depression and markers of CHF (New York Heart Association [NYHA] functional class, N-terminal-prohormone B-type natriuretic peptide [NT-proBNP], and left ventricular ejection fraction [LVEF]) in a longitudinal study over a period of 2 ye...
#1Markus B. Heckmann (University Hospital Heidelberg)H-Index: 3
#2Ashraf Yusuf Rangrez (CAU: University of Kiel)H-Index: 11
Last. Oliver J. Müller (CAU: University of Kiel)H-Index: 20
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Non-cardiac surgery is associated with significant cardiovascular complications. Reported mortality rate ranges from 1.9% to 4% in unselected patients. A postoperative surge in pro-inflammatory cytokines is a well-known feature and putative contributor to these complications. Despite much clinical research, little is known about the biomolecular changes in cardiac tissue following non-cardiac surgery. In order to increase our understanding, we analyzed whole-transcriptional and metabolic profili...
#1Allan S. Jaffe (Mayo Clinic)H-Index: 79
#2JohnGFCleland (Robertson Centre for Biostatistics)H-Index: 115
Last. Hugo A. Katus (University Hospital Heidelberg)H-Index: 99
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2 CitationsSource
#1L. Christian Napp (MHH: Hannover Medical School)H-Index: 12
#2Victoria L. Cammann (UZH: University of Zurich)H-Index: 10
Last. Eduardo BossoneH-Index: 53
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AIMS Takotsubo syndrome (TTS) is an acute heart failure syndrome, which shares many features with acute coronary syndrome (ACS). Although TTS was initially described with angiographically normal coronary arteries, smaller studies recently indicated a potential coexistence of coronary artery disease (CAD) in TTS patients. This study aimed to determine the coexistence, features, and prognostic role of CAD in a large cohort of patients with TTS. METHODS AND RESULTS Coronary anatomy and CAD were stu...
#1Armstrong C (Heidelberg University)
#2Tim Christian Kuhn (Heidelberg University)
Last. A. Heininger (University Hospital Heidelberg)H-Index: 3
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AIMS Upon suspicion of infective endocarditis, the causative microorganism must be identified to optimize treatment. Blood cultures and culturing of removed valves are the mainstay of this diagnosis and should be complemented by growth-independent methods. We assessed the diagnostic benefit of examining removed endocarditis valves by broad-range bacterial PCR to detect causative bacteria in cases where culturing was not available, negative, or inconclusive because a skin commensal was detected, ...
#1Erik A Blackwood (SDSU: San Diego State University)H-Index: 4
#2Donna J. Thuerauf (SDSU: San Diego State University)H-Index: 30
Last. Hugo A. Katus (University Hospital Heidelberg)H-Index: 99
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Abstract The effects of ER stress on protein secretion by cardiac myocytes are not well understood. In this study, the ER stressor thapsigargin (TG), which depletes ER calcium, induced death of cultured neonatal rat ventricular myocytes (NRVMs) in high media volume but fostered protection in low media volume. In contrast, another ER stressor, tunicamycin (TM), a protein glycosylation inhibitor, induced NRVM death in all media volumes, suggesting that protective proteins were secreted in response...
#1Samer Al SaidH-Index: 1
#2Hugo A. KatusH-Index: 99
Last. Samer AlabedH-Index: 8
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One in ten people undergoing percutaneous coronary intervention (PCI) has underlying atrial fibrillation (AF). They are often treated with long-term oral anticoagulation for stroke prevention and are commenced on antiplatelet therapy post-PCI to prevent stent thrombosis.1 A careful balance of risk of bleeding versus thrombosis is essential. Options for oral anticoagulation include vitamin K antagonists (VKAs), for example, warfarin, and non‐vitamin K antagonist oral anticoagulants (NOACs), also ...
#1Lutz Frankenstein (Heidelberg University)H-Index: 22
#2Klaus Kaier (University of Freiburg)H-Index: 15
Last. Hanna Fröhlich (Heidelberg University)H-Index: 7
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BACKGROUND The introduction of percutaneous mitral valve (MV) repair had an effect on clinical practice in comparison with surgical MV repair. Complete nationwide data are useful in examining how the introduction of a new technique influences clinical practice. METHODS We analyzed procedural numbers, patient characteristics, and in-hospital outcomes for all percutaneous edge-to-edge and surgical MV reconstruction procedures performed in Germany between 2009 and 2015. RESULTS 12,664 percutaneous ...
BACKGROUND: Evidence on disease-related quality of life (DRQoL) of patients with implantable cardioverter-defibrillators (ICDs) has been described heterogeneously. Disease-specific measures of DRQoL in ICD patients are lacking. OBJECTIVES: The aim of this study was to gain a broader understanding of long-term DRQoL in ICD patients. Special focus was placed on stressors and cognitive management strategies in everyday life. METHODS: Data assessment was performed via semistructured, guideline-based...