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Steven Hamley
Deakin University
8Publications
5H-index
78Citations
Publications 8
Newest
Published on Sep 6, 2019in Diabetologia7.11
Steven Hamley5
Estimated H-index: 5
(Deakin University),
Danielle Kloosterman (Deakin University)+ 11 AuthorsMaria G. Morales-Scholz (Deakin University)
Aims/hypothesis This study aimed to examine the metabolic health of young apparently healthy non-obese adults to better understand mechanisms of hyperinsulinaemia.
Published on Jun 1, 2019in Molecular metabolism6.18
Ahrathy Selathurai9
Estimated H-index: 9
(Deakin University),
Greg M. Kowalski8
Estimated H-index: 8
(Deakin University)
+ 11 AuthorsAnnie R. Curtis (Deakin University)
Abstract Objective Phosphatidylethanolamine (PtdEtn) is a major phospholipid in mammals. It is synthesized via two pathways, the CDP-ethanolamine pathway in the endoplasmic reticulum and the phosphatidylserine (PtdSer) decarboxylase (PSD) pathway in the mitochondria. While the CDP-ethanolamine pathway is considered the major route for PtdEtn synthesis in most mammalian tissues, little is known about the importance of the PSD pathway in vivo, especially in tissues enriched with mitochondria such ...
Published on Dec 1, 2017in Nutrition Journal3.59
Steven Hamley5
Estimated H-index: 5
(Deakin University)
A cornerstone of conventional dietary advice is the recommendation to replace saturated fatty acids (SFA) with mostly n-6 polyunsaturated fatty acids (PUFA) to reduce the risk of coronary heart disease (CHD). Many clinical trials aimed to test this advice and have had their results pooled in several meta-analyses. However, earlier meta-analyses did not sufficiently account for major confounding variables that were present in some of those trials. Therefore, the aim of the study was to account fo...
Published on Sep 1, 2017in Diabetes7.20
Greg M. Kowalski8
Estimated H-index: 8
(Deakin University),
Samantha M. Moore1
Estimated H-index: 1
(Deakin University)
+ 2 AuthorsClinton R. Bruce42
Estimated H-index: 42
(Deakin University)
Insulin clamp studies have shown that the suppressive actions of insulin on endogenous glucose production (EGP) are markedly more sensitive than for stimulating glucose disposal ( R d ). However, clamp conditions do not adequately mimic postprandial physiological responses. Here, using the variable infusion dual-tracer approach, we used a threefold range of ingested glucose doses (25, 50, and 75 g) to investigate how physiological changes in plasma insulin influence EGP in healthy subjects. Rema...
Published on Jul 1, 2016in Scientific Reports4.01
Greg M. Kowalski8
Estimated H-index: 8
,
Steven Hamley5
Estimated H-index: 5
+ 7 AuthorsClinton R. Bruce42
Estimated H-index: 42
In humans, low-energy diets rapidly reduce hepatic fat and improve/normalise glycemic control. Due to difficulties in obtaining human liver, little is known about changes to the lipid species and pathway fluxes that occur under these conditions. Using a combination of stable isotope, and targeted metabolomic approaches we investigated the acute (7–9 days) hepatic effects of switching high-fat high-sucrose diet (HFD) fed obese mice back to a chow diet. Upon the switch, energy intake was reduced, ...
Published on Aug 1, 2015in Biochemical and Biophysical Research Communications2.71
Greg M. Kowalski8
Estimated H-index: 8
(Deakin University),
David P. De Souza19
Estimated H-index: 19
(University of Melbourne)
+ 9 AuthorsSean O'Callaghan3
Estimated H-index: 3
(University of Melbourne)
Abstract Rationale Cardiac metabolism is thought to be altered in insulin resistance and type 2 diabetes (T2D). Our understanding of the regulation of cardiac substrate metabolism and insulin sensitivity has largely been derived from ex vivo preparations which are not subject to the same metabolic regulation as in the intact heart in vivo . Studies are therefore required to examine in vivo cardiac glucose metabolism under physiologically relevant conditions. Objective To determine the temporal p...
Published on Jun 1, 2015in Biochemical and Biophysical Research Communications2.71
Greg M. Kowalski8
Estimated H-index: 8
(Deakin University),
David P. De Souza19
Estimated H-index: 19
(University of Melbourne)
+ 7 AuthorsClinton R. Bruce42
Estimated H-index: 42
(Deakin University)
Abstract Rationale Defects in muscle glucose metabolism are linked to type 2 diabetes. Mechanistic studies examining these defects rely on the use of high fat-fed rodent models and typically involve the determination of muscle glucose uptake under insulin-stimulated conditions. While insightful, they do not necessarily reflect the physiology of the postprandial state. In addition, most studies do not examine aspects of glucose metabolism beyond the uptake process. Here we present an approach to ...
Published on Feb 1, 2015in Biochimica et Biophysica Acta3.79
Grzegorz M Kowalski6
Estimated H-index: 6
(Monash University),
Joachim Kloehn8
Estimated H-index: 8
(University of Melbourne)
+ 8 AuthorsMalcolm J. McConville59
Estimated H-index: 59
(University of Melbourne)
Hepatic insulin resistance is a major risk factor for the development of type 2 diabetes and is associated with the accumulation of lipids, including diacylglycerol (DAG), triacylglycerols (TAG) and ceramide. There is evidence that enzymes involved in ceramide or sphingolipid metabolism may have a role in regulating concentrations of glycerolipids such as DAG and TAG. Here we have investigated the role of sphingosine kinase (SphK) in regulating hepatic lipid levels. We show that mice on a high-f...
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