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Steven Hamley
Deakin University
8Publications
6H-index
101Citations
Publications 8
Newest
#1Steven Hamley (Deakin University)H-Index: 6
#2Danielle Kloosterman (Deakin University)
Last.Clinton R. Bruce (Deakin University)H-Index: 43
view all 14 authors...
Aims/hypothesis This study aimed to examine the metabolic health of young apparently healthy non-obese adults to better understand mechanisms of hyperinsulinaemia.
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#1Ahrathy Selathurai (Deakin University)H-Index: 9
#2Grzegorz M Kowalski (Deakin University)H-Index: 7
Last.Clinton R. Bruce (Deakin University)H-Index: 43
view all 14 authors...
Abstract Objective Phosphatidylethanolamine (PtdEtn) is a major phospholipid in mammals. It is synthesized via two pathways, the CDP-ethanolamine pathway in the endoplasmic reticulum and the phosphatidylserine (PtdSer) decarboxylase (PSD) pathway in the mitochondria. While the CDP-ethanolamine pathway is considered the major route for PtdEtn synthesis in most mammalian tissues, little is known about the importance of the PSD pathway in vivo, especially in tissues enriched with mitochondria such ...
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#1Steven Hamley (Deakin University)H-Index: 6
A cornerstone of conventional dietary advice is the recommendation to replace saturated fatty acids (SFA) with mostly n-6 polyunsaturated fatty acids (PUFA) to reduce the risk of coronary heart disease (CHD). Many clinical trials aimed to test this advice and have had their results pooled in several meta-analyses. However, earlier meta-analyses did not sufficiently account for major confounding variables that were present in some of those trials. Therefore, the aim of the study was to account fo...
28 CitationsSource
#1Greg M. Kowalski (Deakin University)H-Index: 9
#2Samantha M. Moore (Deakin University)H-Index: 1
Last.Clinton R. Bruce (Deakin University)H-Index: 43
view all 5 authors...
Insulin clamp studies have shown that the suppressive actions of insulin on endogenous glucose production (EGP) are markedly more sensitive than for stimulating glucose disposal ( R d ). However, clamp conditions do not adequately mimic postprandial physiological responses. Here, using the variable infusion dual-tracer approach, we used a threefold range of ingested glucose doses (25, 50, and 75 g) to investigate how physiological changes in plasma insulin influence EGP in healthy subjects. Rema...
8 CitationsSource
#1Greg M. KowalskiH-Index: 9
#2Steven HamleyH-Index: 6
Last.Clinton R. BruceH-Index: 43
view all 10 authors...
In humans, low-energy diets rapidly reduce hepatic fat and improve/normalise glycemic control. Due to difficulties in obtaining human liver, little is known about changes to the lipid species and pathway fluxes that occur under these conditions. Using a combination of stable isotope, and targeted metabolomic approaches we investigated the acute (7–9 days) hepatic effects of switching high-fat high-sucrose diet (HFD) fed obese mice back to a chow diet. Upon the switch, energy intake was reduced, ...
12 CitationsSource
#1Greg M. Kowalski (Deakin University)H-Index: 9
#2David P. De Souza (University of Melbourne)H-Index: 22
Last.Clinton R. Bruce (Deakin University)H-Index: 43
view all 12 authors...
Abstract Rationale Cardiac metabolism is thought to be altered in insulin resistance and type 2 diabetes (T2D). Our understanding of the regulation of cardiac substrate metabolism and insulin sensitivity has largely been derived from ex vivo preparations which are not subject to the same metabolic regulation as in the intact heart in vivo . Studies are therefore required to examine in vivo cardiac glucose metabolism under physiologically relevant conditions. Objective To determine the temporal p...
9 CitationsSource
#1Greg M. Kowalski (Deakin University)H-Index: 9
#2David P. De Souza (University of Melbourne)H-Index: 22
Last.Clinton R. Bruce (Deakin University)H-Index: 43
view all 10 authors...
Rationale: Defects in muscle glucose metabolism are linked to type 2 diabetes. Mechanistic studies examining these defects rely on the use of high fat-fed rodent models and typically involve the determination of muscle glucose uptake under insulin-stimulated conditions. While insightful, they do not necessarily reflect the physiology of the postprandial state. In addition, most studies do not examine aspects of glucose metabolism beyond the uptake process. Here we present an approach to study ro...
23 CitationsSource
#1Grzegorz M Kowalski (Monash University)H-Index: 7
#2Joachim Kloehn (University of Melbourne)H-Index: 8
Last.Clinton R. Bruce (Monash University)H-Index: 43
view all 11 authors...
Hepatic insulin resistance is a major risk factor for the development of type 2 diabetes and is associated with the accumulation of lipids, including diacylglycerol (DAG), triacylglycerols (TAG) and ceramide. There is evidence that enzymes involved in ceramide or sphingolipid metabolism may have a role in regulating concentrations of glycerolipids such as DAG and TAG. Here we have investigated the role of sphingosine kinase (SphK) in regulating hepatic lipid levels. We show that mice on a high-f...
21 CitationsSource
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