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John O. Holloszy
Washington University in St. Louis
308Publications
110H-index
28.8kCitations
Publications 308
Newest
Published on May 1, 2017in Cell Metabolism 20.57
Jin-Ho Koh1
Estimated H-index: 1
(Washington University in St. Louis),
Chad R. Hancock16
Estimated H-index: 16
(Washington University in St. Louis)
+ 3 AuthorsDong-Ho Han25
Estimated H-index: 25
(Washington University in St. Louis)
Summary The objective of this study was to evaluate the specific mechanism(s) by which PPARβ regulates mitochondrial content in skeletal muscle. We discovered that PPARβ increases PGC-1α by protecting it from degradation by binding to PGC-1α and limiting ubiquitination. PPARβ also induces an increase in nuclear respiratory factor 1 (NRF-1) expression, resulting in increases in mitochondrial respiratory chain proteins and MEF2A, for which NRF-1 is a transcription factor. There was also an increas...
11 Citations Source Cite
Published on Jul 13, 2016
Simin Nikbin Meydani59
Estimated H-index: 59
,
Sai Krupa Das27
Estimated H-index: 27
+ 11 AuthorsMegan Huang3
Estimated H-index: 3
Calorie restriction (CR) inhibits inflammation and slows aging in many animal species, but in rodents housed in pathogen-free facilities, CR impairs immunity against certain pathogens. However, little is known about the effects of long-term moderate CR on immune function in humans. In this multi-center, randomized clinical trial to determine CR's effect on inflammation and cell-mediated immunity, 218 healthy non-obese adults (20-50 y), were assigned 25% CR (n=143) or an ad-libitum (AL) diet (n=7...
18 Citations Source Cite
Published on Jan 1, 2016in Cell Reports 8.03
Ling Yang9
Estimated H-index: 9
(Harvard University),
Danilo Licastro12
Estimated H-index: 12
(AREA Science Park)
+ 8 AuthorsJohn O. Holloszy110
Estimated H-index: 110
(Washington University in St. Louis)
Summary Calorie restriction (CR) retards aging, acts as a hormetic intervention, and increases serum corticosterone and HSP70 expression in rodents. However, less is known regarding the effects of CR on these factors in humans. Serum cortisol and molecular chaperones and autophagic proteins were measured in the skeletal muscle of subjects on CR diets for 3–15 years and in control volunteers. Serum cortisol was higher in the CR group than in age-matched sedentary and endurance athlete groups (15....
32 Citations Source Cite
Published on Jan 1, 2016
Dennis T. Villareal42
Estimated H-index: 42
,
Luigi Fontana47
Estimated H-index: 47
+ 5 AuthorsJohn O. Holloszy110
Estimated H-index: 110
16 Citations
Published on Feb 1, 2016in Aging Cell 7.63
Luigi Fontana47
Estimated H-index: 47
(University of Brescia),
Dennis T. Villareal42
Estimated H-index: 42
(Washington University in St. Louis)
+ 8 AuthorsEric Ravussin100
Estimated H-index: 100
(Pennington Biomedical Research Center)
Young‐onset calorie restriction (CR) in rodents decreases serum IGF‐1 concentration and increases serum corticosterone levels, which have been hypothesized to play major roles in mediating its anticancer and anti‐aging effects. However, little is known on the effects of CR on the IGF‐1 system and cortisol in humans. To test the sustained effects of CR on these key hormonal adaptations, we performed a multicenter randomized trial of a 2‐year 25% CR intervention in 218 nonobese (body mass index be...
38 Citations Source Cite
Published on Feb 1, 2015in The Journal of Physiology
Sang Hyun Kim8
Estimated H-index: 8
(Washington University in St. Louis),
Jin Ho Koh1
Estimated H-index: 1
(Washington University in St. Louis)
+ 3 AuthorsDong Ho Han14
Estimated H-index: 14
(Washington University in St. Louis)
Endurance exercise training can increase the ability to perform prolonged strenuous exercise. The major adaptation responsible for this increase in endurance is an increase in muscle mitochondria. This adaptation occurs too slowly to provide a survival advantage when there is a sudden change in environment that necessitates prolonged exercise. In the present study, we discovered another, more rapid adaptation, a downregulation of expression of the glycogenolytic and glycolytic enzymes in muscle ...
13 Citations Source Cite
Published on Jan 1, 2015
John O. Holloszy110
Estimated H-index: 110
,
J. S. Fisher + 22 AuthorsJoffrey Zoll17
Estimated H-index: 17
Eric Ravussin100
Estimated H-index: 100
(Pennington Biomedical Research Center),
Leanne M. Redman36
Estimated H-index: 36
(Pennington Biomedical Research Center)
+ 19 AuthorsDennis T. Villareal42
Estimated H-index: 42
(Washington University in St. Louis)
Background. Caloric restriction (CR), energy intake reduced below ad libitum (AL) intake, increases life span in many species. The implications for humans can be clarified by randomized controlled trials of CR.
113 Citations Source Cite
Published on Jan 1, 2015
R. C. Hickner6
Estimated H-index: 6
,
John O. Holloszy110
Estimated H-index: 110
+ 15 AuthorsShigeru Yatoh17
Estimated H-index: 17
Published on Jan 1, 2015
John O. Holloszy110
Estimated H-index: 110
,
R. C. Hickner6
Estimated H-index: 6
+ 14 AuthorsMichele Schiavon10
Estimated H-index: 10
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