Shamala Devi Sekaran
University of Malaya
VirologyImmunologyDengue virusDengue feverBiology
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Publications 197
#1Zhuo Lin Chong (UM: University of Malaya)
Last. Chiu Wan Ng (UM: University of Malaya)H-Index: 9
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BACKGROUND: Dengue is an emerging infectious disease that infects up to 390 million people yearly. The growing demand of dengue diagnostics especially in low-resource settings gave rise to many rapid diagnostic tests (RDT). This study evaluated the accuracy and utility of ViroTrack Dengue Acute - a new biosensors-based dengue NS1 RDT, SD Bioline Dengue Duo NS1/IgM/IgG combo - a commercially available RDT, and SD Dengue NS1 Ag enzyme-linked immunosorbent assay (ELISA), for the diagnosis of acute ...
Objectives We reported tet(S/M) in Streptococcus pneumoniae and investigated its temporal spread in relation to nationwide clinical interventions.
1 CitationsSource
#1Stephanie W. LoH-Index: 4
Last. Yulia UrbanH-Index: 1
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Summary Background Invasive pneumococcal disease remains an important health priority owing to increasing disease incidence caused by pneumococci expressing non-vaccine serotypes. We previously defined 621 Global Pneumococcal Sequence Clusters (GPSCs) by analysing 20 027 pneumococcal isolates collected worldwide and from previously published genomic data. In this study, we aimed to investigate the pneumococcal lineages behind the predominant serotypes, the mechanism of serotype replacement in di...
13 CitationsSource
#1Sara Pourshahrestani (UM: University of Malaya)H-Index: 7
#2Ehsan Zeimaran (Monash University)H-Index: 7
Last. Tunku Kamarul (UM: University of Malaya)H-Index: 23
view all 9 authors...
Abstract A novel series of silver-doped mesoporous bioactive glass/poly(1,8-octanediol citrate) (AgMBG/POC) elastomeric biocomposite scaffolds were successfully constructed by a salt-leaching technique for the first time and the effect of inclusion of different AgMBG contents (5, 10, and 20 wt%) on physicochemical and biological properties of pure POC elastomer was evaluated. Results indicated that AgMBG particles were uniformly dispersed in the POC matrix and increasing the AgMBG concentration ...
1 CitationsSource
#1Swee-Seong Tang (UM: University of Malaya)H-Index: 5
#2Zakaria Hossain Prodhan (UM: University of Malaya)H-Index: 2
Last. Shamala Devi SekaranH-Index: 32
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Abstract Antimicrobial peptides (AMPs), the self-defence products of organisms, are extensively distributed in plants. They can be classified into several groups, including thionins, defensins, snakins, lipid transfer proteins, glycine-rich proteins, cyclotides and hevein-type proteins. AMPs can be extracted and isolated from different plants and plant organs such as stems, roots, seeds, flowers and leaves. They perform various physiological defensive mechanisms to eliminate viruses, bacteria, f...
9 CitationsSource
#1Hassan Mahmood Jindal (UM: University of Malaya)H-Index: 3
#2Babu Ramanathan (University of Kuala Lumpur)H-Index: 2
Last. Shamala Devi SekaranH-Index: 32
view all 7 authors...
Background Streptococcus pneumoniae or pneumococcus is a leading cause of morbidity and mortality worldwide, specifically in relation to community-acquired pneumonia. Due to the overuse of antibiotics, S. pneumoniae has developed a high degree of resistance to a wide range of antibacterial drugs.
#1Nadiya Taha Darwish (UM: University of Malaya)H-Index: 4
#2Shamala Devi Sekaran (UM: University of Malaya)H-Index: 32
Last. Sook Mei Khor (UM: University of Malaya)H-Index: 12
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Abstract In this review, we describe the existing diagnostic tests, rapid diagnostic tests, and emerging point-of-care diagnostic assays for diseases caused by dengue virus (DENV). We organize these recently reported diagnostic technologies by the type of detection platform. First, fabrication of the platform of several modules used for detection of DENV biomarkers is explained. This section is followed by an assessment of the advantages, disadvantages, and limitations of the different diagnosti...
11 CitationsSource
#1Nadiya Taha Darwish (UM: University of Malaya)H-Index: 4
#2Shamala Devi Sekaran (UM: University of Malaya)H-Index: 32
Last. Sook Mei Khor (UM: University of Malaya)H-Index: 12
view all 4 authors...
Abstract The sharp increase in incidence of dengue infection has necessitated the development of methods for the rapid diagnosis of this deadly disease. Here we report the design and development of a reliable, sensitive, and specific optical immunosensor for the detection of the dengue nonstructural protein 1 (NS1) biomarker in clinical samples obtained during early stages of infection. The present optical NS1 immunosensor comprises a biosensing surface consisting of specific monoclonal NS1 anti...
4 CitationsSource
#1Hui Jen SoeH-Index: 2
#2Yean K. YongH-Index: 12
Last. Shamala Devi SekaranH-Index: 32
view all 7 authors...
4 CitationsSource
#1Shahadat Hossan (University of Nottingham)H-Index: 7
#2Hassan Mahmood Jindal (UM: University of Malaya)H-Index: 3
Last. Christophe Wiart (University of Nottingham)H-Index: 17
view all 11 authors...
AbstractContext: The resistance of bacteria to antibiotics is raising serious concern globally. Asian medicinal plants could improve the current treatment strategies for bacterial infections. The antibacterial properties of medicinal plants used by the Khyang tribe in Bangladesh have not been investigated.Objective: The present study examines the antibacterial properties of 18 medicinal plants used by the Khyang tribe in day-to-day practice against human pathogenic bacteria.Materials and methods...
3 CitationsSource