Masato Kasuga
Kobe University
EndocrinologyBiochemistryDiabetes mellitusMedicineBiology
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Publications 556
#1Tetsuya Hosooka (Kobe University)H-Index: 16
#2Yusei Hosokawa (Kobe University)H-Index: 1
Last. Tadahiro Kitamura (Gunma University)H-Index: 34
view all 24 authors...
Although adipocytes are major targets of insulin, the influence of impaired insulin action in adipocytes on metabolic homeostasis remains unclear. We here show that adipocyte-specific PDK1 (3′-phosphoinositide–dependent kinase 1)-deficient (A-PDK1KO) mice manifest impaired metabolic actions of insulin in adipose tissue and reduction of adipose tissue mass. A-PDK1KO mice developed insulin resistance, glucose intolerance, and hepatic steatosis, and this phenotype was suppressed by additional ablat...
#1Ayumi KannoH-Index: 6
#2Shun-ichiro AsaharaH-Index: 14
Last. Alberto Bartolome (Columbia University)H-Index: 12
view all 23 authors...
EIF2AK4, which encodes the amino acid deficiency-sensing protein GCN2, has been implicated as a susceptibility gene for type 2 diabetes in the Japanese population. However, the mechanism by which GCN2 affects glucose homeostasis is unclear. Here, we show that insulin secretion is reduced in individuals harboring the risk allele of EIF2AK4 and that maintenance of GCN2-deficient mice on a high-fat diet results in a loss of pancreatic beta cell mass. Our data suggest that GCN2 senses amino acid def...
#1Toshiko TakaoH-Index: 8
#2Machi Suka (Jikei University School of Medicine)H-Index: 9
Last. Masato KasugaH-Index: 85
view all 4 authors...
AIMS/INTRODUCTION: We assessed the relationship between diabetic retinopathy (DR) and/or diabetic kidney disease (DKD) according to their severity and all-cause, cancer, vascular, and non-cancer non-vascular mortality in real-world patients with type 2 diabetes. MATERIALS AND METHODS: A total of 1902 patients with type 2 diabetes were enrolled from 1995-1999 and followed to 2017. At baseline, DR was diagnosed in 374 patients, DKD in 529, vision-threatening DR in 123, and advanced DKD in 287. Pat...
#1Wakiko IwataH-Index: 1
Last. Yasuo Terauchi (YCU: Yokohama City University)H-Index: 59
view all 13 authors...
Obesity can initiate and accelerate the progression of kidney diseases. However, it remains unclear how obesity affects renal dysfunction. Here, we show that a newly generated podocyte-specific tubular sclerosis complex 2 (Tsc2) knockout mouse model (Tsc2Deltapodocyte) develops proteinuria and dies due to end-stage renal dysfunction by 10 weeks of age. Tsc2Deltapodocyte mice exhibit an increased glomerular size and focal segmental glomerulosclerosis, including podocyte foot process effacement, m...
#1Toshiko TakaoH-Index: 8
#2Kazuyuki Takahashi (Akita University)H-Index: 1
Last. Masato KasugaH-Index: 85
view all 12 authors...
AIMS/INTRODUCTION: There is little evidence on the role of postprandial glycemia in the incidence of diabetic retinopathy (DR) in a real-world setting. We aimed to assess the effect of postprandial hyperglycemia at clinic visits on the incidence of DR in patients with type 2 diabetes, and whether its effect differs depending on glycated hemoglobin (HbA1c) values and age. MATERIALS AND METHODS: Intrapersonal mean blood glucose levels at 1-2 h post-breakfast (1-2h-PBBG), post-lunch (1-2 h-PLBG) an...
#1Yuka InabaH-Index: 7
#1Yuka Inaba (Kanazawa University)H-Index: 15
Last. Hiroshi Inoue (Kanazawa University)H-Index: 28
view all 10 authors...
: Sodium-glucose cotransporter 2 inhibitor (SGLT2i) consistently reduces blood glucose levels in type 2 diabetes mellitus but increases hepatic gluconeogenic gene expression and glucose production, offsetting its glucose-lowering effect. This study aimed to elucidate the effect of SGLT2i on hepatic gluconeogenic response and its mechanism in both insulin-sensitive and insulin-resistant states. A hepatic mouse model was generated to show liver-specific expression of Gaussia luciferase (GLuc) driv...
1 CitationsSource
#1Toshiko TakaoH-Index: 8
#2Yutaka Matsuyama (UTokyo: University of Tokyo)H-Index: 41
Last. Masato KasugaH-Index: 85
view all 5 authors...
Abstract Aims To analyze the duration and extent of the legacy effect on diabetic complications in real-world patients with type 2 diabetes. Methods This was a retrospective cohort study. We included the following three cohorts of patients: diabetic retinopathy (DR) (n = 1107), diabetic kidney disease (DKD) (n = 1486), and cardiovascular disease (CVD) (n = 1485). Patients were enrolled from 1995 to 1999 and followed up to 2017. Endpoints were DR incidence, ≥40% decrease in estimated glomerular f...
#1Jo SatohH-Index: 27
#2Koichi YokonoH-Index: 32
Last. Hidetoshi Yamashita (YU: Yamagata University)H-Index: 5
view all 34 authors...
To ensure that experiences and lessons learned from the unprecedented 2011 Great East Japan Earthquake are used to improve future disaster planning, the Japan Diabetes Society (JDS) launched the “Research and Survey Committee for Establishing Disaster Diabetes Care Systems Based on Relevant Findings from the Great East Japan Earthquake” under the supervision of the Chairman of the JDS. The Committee conducted a questionnaire survey among patients with diabetes, physicians, disaster medical assis...
#1Hitoshi Watanabe (Kanazawa University)H-Index: 13
#2Yuka Inaba (Kanazawa University)H-Index: 7
Last. Hiroshi Inoue (Kanazawa University)H-Index: 28
view all 7 authors...
Impaired hepatic glucose uptake (HGU) causes postprandial hyperglycemia in type 2 diabetes. Here, we show that diminished hepatic Sirt2 activity impairs HGU in obese diabetic mice. Hepatic Sirt2 overexpression increases HGU in high-fat diet (HFD)-fed obese diabetic mice and mitigates their impaired glucose tolerance. Hepatic Sirt2 knockdown in non-diabetic mice reduces HGU and causes impaired glucose tolerance. Sirt2 promotes glucose-dependent HGU by deacetylating K126 of glucokinase regulatory ...
12 CitationsSource
#1Hiroyuki Yano (Nippon Medical School)H-Index: 3
#2Mashito SakaiH-Index: 9
Last. Michihiro MatsumotoH-Index: 28
view all 16 authors...
Glucagon-mediated gene transcription in the liver is critical for maintaining glucose homeostasis. Promoting the induction of gluconeogenic genes and blocking that of insulin receptor substrate (Irs)2 in hepatocytes contributes to the pathogenesis of type 2 diabetes. However, the molecular mechanism by which glucagon signalling regulates hepatocyte metabolism is not fully understood. We previously showed that a fasting-inducible signalling module consisting of general control non-repressed prote...