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James D. Otvos
North Carolina State University
236Publications
52H-index
10.9kCitations
Publications 232
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Background Chronic kidney disease is associated with structural and compositional abnormalities in high‐density lipoprotein particles (HDLp). We examined associations of HDLp size, particle subfrac...
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Background: Gut microbiota-related metabolites, trimethylamine-N-oxide (TMAO), choline, and betaine, have been shown to be associated with cardiovascular disease (CVD) risk. Moreover, lower plasma betaine concentrations have been reported in subjects with type 2 diabetes mellitus (T2DM). However, few studies have explored the association of betaine with incident T2DM, especially in the general population. The goals of this study were to evaluate the performance of a newly developed betaine assay...
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#1Jose L. Flores-Guerrero (UMCG: University Medical Center Groningen)H-Index: 2
#2Dion Groothof (UMCG: University Medical Center Groningen)
Last.Robin P. F. Dullaart (UMCG: University Medical Center Groningen)H-Index: 46
view all 6 authors...
The potential role of branched-chain amino acids (BCAAs) in the pathogenesis of cardiometabolic diseases is increasingly recognized, but the association of BCAAs with incident hypertension remains ...
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#1Oluwaseun E. Fashanu (Johns Hopkins University)H-Index: 3
#2Abayomi O. Oyenuga (UMN: University of Minnesota)H-Index: 1
Last.Erin Donnelly Michos (Johns Hopkins University)H-Index: 41
view all 8 authors...
GlycA, a composite biomarker of systemic inflammation, is associated with cardiovascular disease (CVD) and mortality, but its relationship with peripheral artery disease (PAD) is unknown. We assess...
1 CitationsSource
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#1Vincent DelatourH-Index: 8
Last.Philippe GilleryH-Index: 33
view all 15 authors...
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#1Leanna M. Ross (Duke University)H-Index: 1
#2Cris A. Slentz (Duke University)H-Index: 36
Last.William E. Kraus (Duke University)H-Index: 79
view all 7 authors...
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#1Martin Tibuakuu (Johns Hopkins University)H-Index: 4
#2Oluwaseun E. Fashanu (Johns Hopkins University)H-Index: 3
Last.Erin Donnelly Michos (Johns Hopkins University)H-Index: 41
view all 14 authors...
3 CitationsSource
#1Angelica K. Ezeigwe (Johns Hopkins University)H-Index: 1
#2Oluwaseun E. Fashanu (Johns Hopkins University)H-Index: 3
Last.Erin Donnelly Michos (Johns Hopkins University)H-Index: 41
view all 9 authors...
Abstract Background and aims GlycA is a novel composite biomarker of systemic inflammation reflecting posttranslational glycosylation of acute phase reactants. GlycA has been associated with coronary artery calcium, cardiovascular disease (CVD) events and mortality. Vascular calcifications outside of the coronary arteries are risk markers of CVD and mortality. Whether GlycA is linked to extra-coronary calcifications (ECC) is not well established. Methods We studied 6462 MESA participants free of...
2 CitationsSource
Background: Low circulating magnesium (Mg) is associated with an increased risk of developing type 2 diabetes mellitus (T2DM). We aimed to study the performance of a nuclear magnetic resonance (NMR)-based assay that quantifies ionized Mg in EDTA plasma samples and prospectively investigate the association of Mg with the risk of T2DM. Methods: The analytic performance of an NMR-based assay for measuring plasma Mg was evaluated. We studied 5747 subjects free of T2DM at baseline in the Prevention o...
2 CitationsSource
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