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Klaus Groschner
Medical University of Graz
TRPCChemistryTRPC3BiochemistryBiology
185Publications
39H-index
4,965Citations
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Publications 184
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#1Niroj Shrestha (Medical University of Graz)H-Index: 5
#2Bernadett Bacsa (Medical University of Graz)H-Index: 1
Last. Klaus Groschner (Medical University of Graz)H-Index: 39
view all 8 authors...
Trimeric intracellular cation (TRIC) channels have been proposed to modulate Ca2+ release from the endoplasmic reticulum (ER) and determine oscillatory Ca2+ signals. Here, we report that TRIC-A–mediated amplitude and frequency modulation of ryanodine receptor 2 (RyR2)-mediated Ca2+ oscillations and inositol 1,4,5-triphosphate receptor (IP3R)-induced cytosolic signals is based on attenuating store-operated Ca2+ entry (SOCE). Further, TRIC-A–dependent delay in ER Ca2+ store refilling contributes t...
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#1Annarita Graziani (Medical University of Graz)H-Index: 7
#2Bernadett Bacsa (Medical University of Graz)H-Index: 1
Last. Klaus Groschner (Medical University of Graz)H-Index: 39
view all 8 authors...
Canonical transient receptor potential (TRPC) channels were identified as key players in maladaptive remodeling, with nuclear factor of activated T-cells (NFAT) transcription factors serving as downstream targets of TRPC-triggered Ca2+ entry in these pathological processes. Strikingly, the reconstitution of TRPC-NFAT signaling by heterologous expression yielded controversial results. Specifically, nuclear translocation of NFAT1 was found barely responsive to recombinant TRPC3, presumably based o...
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#1Bernadett BacsaH-Index: 1
#2Oleksandra TiapkoH-Index: 5
Last. Klaus GroschnerH-Index: 39
view all 5 authors...
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#1Sanja Curcic (Medical University of Graz)H-Index: 7
#2Romana Schober (Johannes Kepler University of Linz)H-Index: 4
Last. Klaus Groschner (Medical University of Graz)H-Index: 39
view all 4 authors...
Abstract Canonical members of the TRP superfamily of ion channels have long been recognized as key elements of Ca2+ handling in a plethora of cell types. The emerging role of TRPC channels in human physiopathology has generated considerable interest in their pharmacological targeting, which requires detailed understanding of their molecular function. Although consent has been reached that receptor-phospholipase C (PLC) pathways and generation of lipid mediators constitute the prominent upstream ...
3 CitationsSource
#1Sanja Curcic (Medical University of Graz)H-Index: 7
#2Oleksandra Tiapko (Medical University of Graz)H-Index: 5
Last. Klaus Groschner (Medical University of Graz)H-Index: 39
view all 3 authors...
Abstract Non-selective cation conductances formed by transient receptor potential canonical (TRPC) proteins govern the function and fate of a wide range of human cell types. In the past decade, evidence has accumulated for a pivotal role of these channels in human diseases, raising substantial interest in their therapeutic targeting. As yet, an appreciable number of small molecules for block and modulation of recombinant TRPC conductances have been identified. However, groundbreaking progress in...
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#1Romana Schober (Johannes Kepler University of Linz)H-Index: 4
#2Linda Waldherr (Medical University of Graz)H-Index: 3
Last. Rainer Schindl (Medical University of Graz)H-Index: 28
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Abstract Since calcium (Ca2+) regulates a large variety of cellular signaling processes in a cell's life, precise control of Ca2+ concentrations within the cell is essential. This enables the transduction of information via Ca2+ changes in a time-dependent and spatially defined manner. Here, we review molecular and functional aspects of how the store-operated Ca2+ channel Orai1 creates spatiotemporal Ca2+ microdomains. The architecture of this channel is unique, with a long helical pore and a si...
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#1Barbora Svobodova (Medical University of Graz)H-Index: 5
#2Michaela Lichtenegger (Medical University of Graz)H-Index: 6
Last. Klaus Groschner (Medical University of Graz)H-Index: 39
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Abstract Mutation of a single residue within the recently identified lipid (diacylglycerol) recognition window of TRPC3 (G652A) was found to abolish channel activation via endogenous lipid mediators while retaining sensitivity to the non-lipid activator GSK1702934A (abb. GSK). The mechanism of this change in chemical sensing by TRPC3 was analysed by whole-cell and single channel electrophysiology as well as Ca2+ imaging. Currents initiated by GSK or the structural (benzimidazole) analog BI-2 wer...
1 CitationsSource
#1Carmen Butorac (Johannes Kepler University of Linz)H-Index: 6
#2Martin Muik (Johannes Kepler University of Linz)H-Index: 25
Last. Christoph Romanin (Johannes Kepler University of Linz)H-Index: 48
view all 13 authors...
Abstract Calcium signalling through store-operated calcium (SOC) entry is of crucial importance for T-cell activation and the adaptive immune response. This entry occurs via the prototypic Ca2+ release-activated Ca2+ (CRAC) channel. STIM1, a key molecular component of this process, is located in the membrane of the endoplasmic reticulum (ER) and is initially activated upon Ca2+ store depletion. This activation signal is transmitted to the plasma membrane via a direct physical interaction that ta...
1 CitationsSource
#1Oleksandra Tiapko (Medical University of Graz)H-Index: 5
#2Niroj Shrestha (Medical University of Graz)H-Index: 5
Last. Klaus Groschner (Medical University of Graz)H-Index: 39
view all 14 authors...
Lipid-gated TRPC channels are highly expressed in cardiovascular and neuronal tissues. Exerting precise pharmacological control over their activity in native cells is expected to serve as a basis for the development of novel therapies. Here we report on a new photopharmacological tool that enables manipulation of TRPC3 channels by light, in a manner independent of lipid metabolism and with higher temporal precision than lipid photopharmacology. Using the azobenzene photoswitch moiety, we modifie...
2 CitationsSource
#1Oleksandra Tiapko (University of Graz)H-Index: 5
#2Sanja Curcic (University of Graz)
Last. Klaus Groschner (University of Graz)H-Index: 39
view all 5 authors...
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