scinapse is loading now...
Anthony F. Domenichiello
University of Toronto
31Publications
12H-index
478Citations
Publications 31
Newest
Anthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health),
Christopher E. Ramsden16
Estimated H-index: 16
(National Institutes of Health)
Abstract Chronic pain is highly prevalent among older adults where it is associated with significant suffering, disability, social isolation, and greater costs and burden to health care systems. Pharmaceutical treatment of chronic pain in older adults is usually only partially effective and is often limited by side effects including urinary retention, constipation, sedation, cognitive impairment, and increased risk of falls. Since older adults are underrepresented in clinical trials testing trea...
Source Cite
J.R. Jensen1
Estimated H-index: 1
(National Institutes of Health),
Mark H. Pitcher5
Estimated H-index: 5
+ 2 AuthorsAnthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health)
Abstract Chronic pain is both a global public health concern and a serious source of personal suffering for which current treatments have limited efficacy. Recently, oxylipins derived from linoleic acid (LA), the most abundantly consumed polyunsaturated fatty acid in the modern diet, have been implicated as mediators of pain in the periphery and spinal cord. However, oxidized linoleic acid derived mediators (OXLAMs) remain understudied in the brain, particularly during pain states. In this study...
1 Citations Source Cite
Published on May 1, 2018in Lipids 1.94
Yuhong Lin5
Estimated H-index: 5
(National Institutes of Health),
Joseph R. Hibbeln46
Estimated H-index: 46
(National Institutes of Health)
+ 9 AuthorsStanley I. Rapoport94
Estimated H-index: 94
(National Institutes of Health)
2 Citations Source Cite
Published on Feb 1, 2018in Journal of Investigative Dermatology 6.45
Alexander V. Sorokin11
Estimated H-index: 11
(National Institutes of Health),
Anthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health)
+ 6 AuthorsNehal N. Mehta37
Estimated H-index: 37
(National Institutes of Health)
Psoriasis is a chronic immune-mediated disease that represents a unique model for investigating inflammation at local and systemic levels. Bioactive lipid mediators (LMs) are potent compounds reported to play a role in the development and resolution of inflammation. Currently, it is not known to what extent these LMs are involved in psoriasis pathophysiology and related metabolic dysfunction. Here, we use targeted and untargeted liquid chromatography-tandem mass spectrometry approaches to quanti...
4 Citations Source Cite
Anthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health),
Breanne C. Wilhite1
Estimated H-index: 1
(National Institutes of Health)
+ 1 AuthorsChristopher E. Ramsden16
Estimated H-index: 16
(National Institutes of Health)
Abstract Inhibition of prostaglandin (PG) biosynthesis has been used to relieve pain for thousands of years. Today non-steroidal anti-inflammatory drugs (which largely inhibit PG synthesis) are widely used to treat pain. Four main types of PGs (PGD2, PGE2, PGF2 and PGI2) are synthesized from arachidonic acid during inflammation and have been demonstrated to impact nociception. PGE2 has been the most studied and utilized for its pain producing properties and has been demonstrated to increase hype...
1 Citations Source Cite
Published on Nov 1, 2017in The Lancet 53.25
Christopher E. Ramsden16
Estimated H-index: 16
(National Institutes of Health),
Anthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health)
8 Citations Source Cite
Published on Oct 1, 2017in Placenta 2.43
Adam H. Metherel6
Estimated H-index: 6
(University of Toronto),
Alex P. Kitson7
Estimated H-index: 7
(University of Toronto)
+ 6 AuthorsRichard P. Bazinet39
Estimated H-index: 39
(University of Toronto)
Abstract Maternal delivery of docosahexaenoic acid (DHA, 22:6n-3) to the developing fetus via the placenta is required for fetal neurodevelopment, and is the only mechanism by which DHA can be accreted in the fetus. The aim of the current study was to utilize a balance model of DHA accretion combined with kinetic measures of serum unesterified DHA uptake to better understand the mechanism by which maternal DHA is delivered to the fetus via the placenta. Female rats maintained on a 2% α-linolenic...
Source Cite
Published on Aug 22, 2017in Science Signaling 6.38
Christopher E. Ramsden16
Estimated H-index: 16
(University of North Carolina at Chapel Hill),
Anthony F. Domenichiello12
Estimated H-index: 12
(Uniformed Services University of the Health Sciences)
+ 16 AuthorsMark S. Horowitz1
Estimated H-index: 1
(National Institutes of Health)
Chronic pain and itch are common hypersensitivity syndromes that are affected by endogenous mediators. We applied a systems-based, translational approach to predict, discover, and characterize mediators of pain and itch that are regulated by diet and inflammation. Profiling of tissue-specific precursor abundance and biosynthetic gene expression predicted that inflamed skin would be abundant in four previously unknown 11-hydroxy-epoxy- or 11-keto-epoxy-octadecenoate linoleic acid derivatives and ...
7 Citations Source Cite
Published on Aug 22, 2017
Christopher E. Ramsden16
Estimated H-index: 16
,
Anthony F. Domenichiello12
Estimated H-index: 12
+ 16 AuthorsMark S. Horowitz1
Estimated H-index: 1
Published on Aug 1, 2017in Journal of Nutritional Biochemistry 4.41
Adam H. Metherel6
Estimated H-index: 6
(University of Toronto),
Alex P. Kitson7
Estimated H-index: 7
(University of Toronto)
+ 6 AuthorsRichard P. Bazinet39
Estimated H-index: 39
(University of Toronto)
Abstract Maternal docosahexaenoic acid (DHA, 22:6n-3) supplies the developing fetus during pregnancy; however, the mechanisms are unclear. We utilized pregnant rats to determine rates of DHA accretion, tissue unesterified DHA uptake and whole-body DHA synthesis-secretion. Female rats maintained on a DHA-free, 2% α-linolenic acid diet were either:1) sacrificed at 56 days for baseline measures, 2) mated and sacrificed at 14–18 days of pregnancy or 3) or sacrificed at 14–18 days as age-matched virg...
6 Citations Source Cite
1234