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Anthony F. Domenichiello
University of Toronto
31Publications
12H-index
478Citations
Publications 31
Newest
#1Yuhong Lin (NIH: National Institutes of Health)H-Index: 5
#2Joseph R. Hibbeln (NIH: National Institutes of Health)H-Index: 46
Last.Stanley I. Rapoport (NIH: National Institutes of Health)H-Index: 94
view all 10 authors...
#1Adam H. Metherel (U of T: University of Toronto)H-Index: 6
#2Alex P. Kitson (U of T: University of Toronto)H-Index: 7
Last.Richard P. Bazinet (U of T: University of Toronto)H-Index: 39
view all 9 authors...
Abstract Maternal delivery of docosahexaenoic acid (DHA, 22:6n-3) to the developing fetus via the placenta is required for fetal neurodevelopment, and is the only mechanism by which DHA can be accreted in the fetus. The aim of the current study was to utilize a balance model of DHA accretion combined with kinetic measures of serum unesterified DHA uptake to better understand the mechanism by which maternal DHA is delivered to the fetus via the placenta. Female rats maintained on a 2% α-linolenic...
#1Adam H. Metherel (U of T: University of Toronto)H-Index: 6
#2Alex P. Kitson (U of T: University of Toronto)H-Index: 7
Last.Richard P. Bazinet (U of T: University of Toronto)H-Index: 39
view all 9 authors...
Abstract Maternal docosahexaenoic acid (DHA, 22:6n-3) supplies the developing fetus during pregnancy; however, the mechanisms are unclear. We utilized pregnant rats to determine rates of DHA accretion, tissue unesterified DHA uptake and whole-body DHA synthesis-secretion. Female rats maintained on a DHA-free, 2% α-linolenic acid diet were either:1) sacrificed at 56 days for baseline measures, 2) mated and sacrificed at 14–18 days of pregnancy or 3) or sacrificed at 14–18 days as age-matched virg...
#1Adam H. Metherel (U of T: University of Toronto)H-Index: 6
#2Anthony F. Domenichiello (U of T: University of Toronto)H-Index: 12
Last.Richard P. Bazinet (U of T: University of Toronto)H-Index: 39
view all 5 authors...
n-3 Tetracosapentaenoic acid (24:5n-3, TPAn-3) and tetracosahexaenoic acid (24:6n-3, THA) are believed to be important intermediates to docosahexaenoic acid (DHA, 22:6n-3) synthesis. The purpose of this study is to report for the first time serum concentrations of TPAn-3 and THA and their response to changing dietary α-linolenic acid (18:3n-3, ALA) and DHA. The responses will then be used in an attempt to predict the location of these fatty acids in relation to DHA in the biosynthetic pathway. M...
#1Adam H. Metherel (U of T: University of Toronto)H-Index: 6
#2Anthony F. Domenichiello (U of T: University of Toronto)H-Index: 12
Last.Richard P. Bazinet (U of T: University of Toronto)H-Index: 39
view all 5 authors...
Abstract Whole body docosahexaenoic acid (DHA, 22:6n-3) synthesis from α-linolenic acid (ALA, 18:3n-3) is considered to be very low, however, the daily synthesis-secretion of DHA may be sufficient to supply the adult brain. The current study aims to assess whether whole body DHA synthesis-secretion kinetics are different when comparing plasma ALA versus eicosapentaenoic acid (EPA, 20:5n-3) as the precursor. Male Long Evans rats (n = 6) were fed a 2% ALA in total fat diet for eight weeks, followe...
#1Alex P. Kitson (U of T: University of Toronto)H-Index: 7
#2Adam H. Metherel (U of T: University of Toronto)H-Index: 6
Last.Richard P. Bazinet (U of T: University of Toronto)H-Index: 39
view all 7 authors...
Abstract Tracer studies suggest that phospholipid DHA (PL-DHA) more effectively targets the brain than triglyceride DHA (TAG-DHA), although the mechanism and whether this translates into higher brain DHA concentrations are not clear. Rats were gavaged with [U- 3 H]PL-DHA and [U- 3 H]TAG-DHA and blood sampled over 6 h prior to collection of brain regions and other tissues. In another experiment, rats were supplemented for 4 weeks with TAG-DHA (fish oil), PL-DHA (roe PL) or a mixture of both for c...
#1Anthony F. Domenichiello (U of T: University of Toronto)H-Index: 12
#2Alex P. Kitson (U of T: University of Toronto)H-Index: 7
Last.Richard P. Bazinet (U of T: University of Toronto)H-Index: 39
view all 6 authors...
Docosahexaenoic acid (DHA) is thought to be important for brain function. The main dietary source of DHA is fish, however, DHA can also be synthesized from precursor omega-3 polyunsaturated fatty acids (n-3 PUFA), the most abundantly consumed being α-linolenic acid (ALA). The enzymes required to synthesize DHA from ALA are also used to synthesize longer chain omega-6 (n-6) PUFA from linoleic acid (LNA). The large increase in LNA consumption that has occurred over the last century has led to conc...
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