Anthony F. Domenichiello
University of Toronto
30Publications
12H-index
463Citations
Publications 30
Newest
J.R. Jensen1
Estimated H-index: 1
(National Institutes of Health),
M.H. Pitcher1
Estimated H-index: 1
+ 2 AuthorsAnthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health)
Abstract Chronic pain is both a global public health concern and a serious source of personal suffering for which current treatments have limited efficacy. Recently, oxylipins derived from linoleic acid (LA), the most abundantly consumed polyunsaturated fatty acid in the modern diet, have been implicated as mediators of pain in the periphery and spinal cord. However, oxidized linoleic acid derived mediators (OXLAMs) remain understudied in the brain, particularly during pain states. In this study...
1 Citations Source Cite
Published on Feb 1, 2018in Journal of Investigative Dermatology 6.45
Alexander V. Sorokin11
Estimated H-index: 11
(National Institutes of Health),
Anthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health)
+ 6 AuthorsNehal N. Mehta36
Estimated H-index: 36
(National Institutes of Health)
Psoriasis is a chronic immune-mediated disease that represents a unique model for investigating inflammation at local and systemic levels. Bioactive lipid mediators (LMs) are potent compounds reported to play a role in the development and resolution of inflammation. Currently, it is not known to what extent these LMs are involved in psoriasis pathophysiology and related metabolic dysfunction. Here, we use targeted and untargeted liquid chromatography-tandem mass spectrometry approaches to quanti...
3 Citations Source Cite
Published on May 1, 2018in Lipids 1.94
Yuhong Lin5
Estimated H-index: 5
(National Institutes of Health),
Joseph R. Hibbeln47
Estimated H-index: 47
(National Institutes of Health)
+ 9 AuthorsStanley I. Rapoport95
Estimated H-index: 95
(National Institutes of Health)
2 Citations Source Cite
Published on Jan 1, 2017in Journal of Nutrition 4.40
Anthony F. Domenichiello12
Estimated H-index: 12
(University of Toronto),
Alex P. Kitson7
Estimated H-index: 7
(University of Toronto)
+ 4 AuthorsRichard P. Bazinet38
Estimated H-index: 38
(University of Toronto)
11 Citations Source Cite
Published on Feb 1, 2017in Lipids 1.94
Adam H. Metherel6
Estimated H-index: 6
(University of Toronto),
Anthony F. Domenichiello12
Estimated H-index: 12
(University of Toronto)
+ 2 AuthorsRichard P. Bazinet38
Estimated H-index: 38
(University of Toronto)
n-3 Tetracosapentaenoic acid (24:5n-3, TPAn-3) and tetracosahexaenoic acid (24:6n-3, THA) are believed to be important intermediates to docosahexaenoic acid (DHA, 22:6n-3) synthesis. The purpose of this study is to report for the first time serum concentrations of TPAn-3 and THA and their response to changing dietary α-linolenic acid (18:3n-3, ALA) and DHA. The responses will then be used in an attempt to predict the location of these fatty acids in relation to DHA in the biosynthetic pathway. M...
7 Citations Source Cite
Published on Aug 22, 2017in Science Signaling 6.38
Christopher E. Ramsden16
Estimated H-index: 16
(University of North Carolina at Chapel Hill),
Anthony F. Domenichiello12
Estimated H-index: 12
(Uniformed Services University of the Health Sciences)
+ 16 AuthorsMark S. Horowitz1
Estimated H-index: 1
(National Institutes of Health)
Chronic pain and itch are common hypersensitivity syndromes that are affected by endogenous mediators. We applied a systems-based, translational approach to predict, discover, and characterize mediators of pain and itch that are regulated by diet and inflammation. Profiling of tissue-specific precursor abundance and biosynthetic gene expression predicted that inflamed skin would be abundant in four previously unknown 11-hydroxy-epoxy- or 11-keto-epoxy-octadecenoate linoleic acid derivatives and ...
6 Citations Source Cite
Published on Oct 1, 2017in Placenta 2.43
Adam H. Metherel6
Estimated H-index: 6
(University of Toronto),
Alex P. Kitson7
Estimated H-index: 7
(University of Toronto)
+ 6 AuthorsRichard P. Bazinet38
Estimated H-index: 38
(University of Toronto)
Abstract Maternal delivery of docosahexaenoic acid (DHA, 22:6n-3) to the developing fetus via the placenta is required for fetal neurodevelopment, and is the only mechanism by which DHA can be accreted in the fetus. The aim of the current study was to utilize a balance model of DHA accretion combined with kinetic measures of serum unesterified DHA uptake to better understand the mechanism by which maternal DHA is delivered to the fetus via the placenta. Female rats maintained on a 2% α-linolenic...
Source Cite
Published on Apr 1, 2017in The Journal of Pain 4.86
Anthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health),
B. Wilhite (National Institutes of Health)+ 2 AuthorsChristopher E. Ramsden16
Estimated H-index: 16
(National Institutes of Health)
Source Cite
Published on Nov 1, 2017in The Lancet 53.25
Christopher E. Ramsden16
Estimated H-index: 16
(National Institutes of Health),
Anthony F. Domenichiello12
Estimated H-index: 12
(National Institutes of Health)
6 Citations Source Cite
Published on Aug 1, 2017in Journal of Nutritional Biochemistry 4.41
Adam H. Metherel6
Estimated H-index: 6
(University of Toronto),
Alex P. Kitson7
Estimated H-index: 7
(University of Toronto)
+ 6 AuthorsRichard P. Bazinet38
Estimated H-index: 38
(University of Toronto)
Abstract Maternal docosahexaenoic acid (DHA, 22:6n-3) supplies the developing fetus during pregnancy; however, the mechanisms are unclear. We utilized pregnant rats to determine rates of DHA accretion, tissue unesterified DHA uptake and whole-body DHA synthesis-secretion. Female rats maintained on a DHA-free, 2% α-linolenic acid diet were either:1) sacrificed at 56 days for baseline measures, 2) mated and sacrificed at 14–18 days of pregnancy or 3) or sacrificed at 14–18 days as age-matched virg...
6 Citations Source Cite
123