Robert G. Frykberg
Midwestern University
Publications 87
#1Robert G. Frykberg (MWU: Midwestern University)H-Index: 35
Last.Sophie Renton (Northwick Park Hospital)H-Index: 2
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OBJECTIVE Topical oxygen has been used for the treatment of chronic wounds for more than 50 years. Its effectiveness remains disputed due to the limited number of robust high-quality investigations. The aim of this study was to assess the efficacy of multimodality cyclical pressure Topical Wound Oxygen (TWO2) home care therapy in healing refractory diabetic foot ulcers (DFUs) that had failed to heal with standard of care (SOC) alone. RESEARCH DESIGN AND METHODS Patients with diabetes and chronic...
#2Robert G. Frykberg (MWU: Midwestern University)H-Index: 35
Last.Dane K. Wukich (UTSW: University of Texas Southwestern Medical Center)H-Index: 31
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ABSTRACTBackground: Foot complications such as ulceration and neuropathy are common complications of diabetes mellitus (DM). Previous reports have demonstrated a possible increased risk of these complications in diabetic patients with low levels of serum vitamin D.Objectctive: The purpose of this study is to compare serum vitamin D levels in diabetic patients with and without Charcot neuroarthropathy (CN), peripheral arterial disease (PAD), infection (DFI), ulceration (DFU), and peripheral neuro...
1 CitationsSource
#1Ian L. GordonH-Index: 1
#2Aksone NouvongH-Index: 2
Last.Robert G. FrykbergH-Index: 35
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Diabetic foot ulcers (DFU) result in significant morbidity, mortality, and healthcare costs. Fortunately, recent data suggest as many as 75% of DFU and 60% of lower extremity amputations (LEA) may be preventable. Clinical practice guidelines recommend evidence-based foot temperature monitoring (thermometry) for preventing DFU and its complications in high-risk patients. Despite this, several authors have noted that thermometry is not commonly practiced. This is potentially due to lack of evidenc...
1 CitationsSource
Non-healing DFUs lead to increased mortality, morbidity and health economic burden. Our RCT (NCT02326337) was undertaken to explore the efficacy of Topical Wound Oxygen (TWO2) homecare therapy in healing DFUs that had failed to heal with Standard of Care (SOC) alone. A Group Sequential Design was utilized with 2 interim analyses, requiring a significance of p 2 =7.2707, P=0.007). Multivariable analysis using logistic regression and Cox proportional hazards modelling of the secondary outcome meas...
#1Lee C. RogersH-Index: 9
#2Robert G. FrykbergH-Index: 35
The diabetic Charcot foot is a potentially limb-threatening deformity associated with peripheral neuropathy and concomitant injury. Often the precipitating injury is fairly minor, but unrecognized due to the underlying peripheral sensory neuropathy. With existing loss of protective sensation the neuropathic individual continues to walk on the injured extremity causing progressive inflammation with varying degrees of bone and joint pathology. Severe deformity can ensue that predisposes to ulcerat...
2 CitationsSource
#1Stephanie C. Wu (RFUMS: Rosalind Franklin University of Medicine and Science)H-Index: 16
#2Richard PollakH-Index: 1
Last.Denesh Chitkara (Celgene)H-Index: 1
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The objective of this study was to examine the safety of cenplacel (PDA-002) in patients with peripheral arterial disease (PAD) and a diabetic foot ulcer (DFU). Cenplacel is a mesenchymal-like cell population derived from full-term human placenta. This phase 1, dose-escalation study investigated cenplacel in diabetic patients with chronic DFUs (Wagner grade 1 or grade 2) and PAD [ankle-brachial index (ABI) >0·5 and ≤0·9], enrolled sequentially into each of four dose cohorts (3 × 106, 10 × 106, 3...
6 CitationsSource
#1Robert G. FrykbergH-Index: 35
#2Ian L. GordonH-Index: 1
Last.Bijan Najafi (UA: University of Arizona)H-Index: 32
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OBJECTIVE We conducted a multicenter evaluation of a novel remote foot-temperature monitoring system to characterize its accuracy for predicting impending diabetic foot ulcers (DFU) in a cohort of patients with diabetes with previously healed DFU. RESEARCH DESIGN AND METHODS We enrolled 132 participants with diabetes and prior DFU in this 34-week cohort study to evaluate a remote foot-temperature monitoring system ( Identifier NCT02647346). The study device was a wireless daily...
16 CitationsSource
#1Robert G. FrykbergH-Index: 35
#2Gary W. GibbonsH-Index: 37
Last.Farrell C Milstein (Osiris Therapeutics, Inc.)H-Index: 2
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Complex diabetic foot ulcers (DFUs) with exposed tendon or bone remain a challenge. They are more susceptible to complications such as infection and amputation and require treatments that promote rapid development of granulation tissue and, ultimately, reepithelialisation. The clinical effectiveness of viable cryopreserved human placental membrane (vCHPM) for DFUs has been established in a level 1 trial. However, complex wounds with exposed deeper structures are typically excluded from randomise...
15 CitationsSource
#1Robert G. FrykbergH-Index: 35
#2Shawn CazzellH-Index: 8
Last.T.W. GilbertH-Index: 1
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Objective: The objective of this prospective, multicentre clinical study is to assess the application of MatriStem MicroMatrix (MSMM) and MatriStem Wound Matrix (MSWM) (porcine urinary bladder derived extracellular matrix) compared with Dermagraft (DG) (human fibroblast-derived dermal substitute) for the management of non-healing diabetic foot ulcers (DFUs). Method: A randomised, multicentre study was conducted at thirteen centers throughout the US. It was designed to evaluate the incidence of u...
8 CitationsSource