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Sven Perner
University of Bonn
CancerProstate cancerCancer researchMedicineBiology
266Publications
43H-index
13.2kCitations
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Publications 192
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The tumor immune microenvironment (TIME) of head and neck squamous cell carcinomas (HNSCC) and other solid malignancies is a key determinant of therapy response and prognosis. Among other factors, it is shaped by the tumor mutational burden and defects in DNA repair enzymes. Based on the TCGA database we aimed to define specific, altered genes associated with different TIME types, which might represent new predictive markers or targets for immuno-therapeutic approaches. The HNSCC cohort of the T...
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#1Simon Laban (University of Ulm)H-Index: 11
#2Romain Remark (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 14
Last. Andrew G. Sikora (BCM: Baylor College of Medicine)H-Index: 31
view all 20 authors...
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#1Jörg Hennenlotter (University of Tübingen)H-Index: 31
#2Tim Neumann (University of Tübingen)H-Index: 1
Last. Steffen Rausch (University of Tübingen)H-Index: 10
view all 7 authors...
INTRODUCTION: The Prostate Cancer gene 3 (PCA3) urine test has gained importance in the diagnostic workup of prostate cancer (PC). Limited evidence suggests that PCA3 is not altered in the presence of inflammation. OBJECTIVE: To assess the impact of histological inflammation on PCA3. METHODS: PCA3 was evaluated in patients prior to prostate biopsy (n = 193) and to radical prostatectomy (n = 197). In patients without PC, inflammation was assessed and quantified by individual scores integrating gr...
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#1E PetrovaH-Index: 2
Last. Ulrich F. WellnerH-Index: 23
view all 12 authors...
In this retrospective study, we analyzed the association between tumor budding and perineural invasion as well as their prognostic role in pancreatic ductal adenocarcinoma. A total of N = 119 patients resected for pancreatic ductal carcinoma from 1996 to 2015 were included. Clinical and standard histopathological parameters were retrieved from the patient’s records. One representative hematoxylin and eosin section from the tumor region was examined for perineural invasion and tumor budding using...
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#1Anne OffermannH-Index: 8
#2Marie C. HupeH-Index: 5
Last. Sven PernerH-Index: 43
view all 5 authors...
Purpose To systematically and comprehensively review and summarize the most recent literature assessing the value of the new grading system introduced by the International Society of Urological Pathology (ISUP) in 2014 and accepted by the World Health Organization (WHO) in 2016.
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#1Nadina Ortiz-Brüchle (RWTH Aachen University)
#1N. Ortiz-Brüchle (RWTH Aachen University)
Last. Nadine T. Gaisa (RWTH Aachen University)H-Index: 12
view all 24 authors...
Hintergrund Aufgrund der technischen Entwicklungen und der zunehmend verbreiteten molekularen Hochdurchsatzanalytik wurden die meisten Karzinomtypen inzwischen molekular subtypisiert. Daraus ergeben sich neue Moglichkeiten der Prazisionsonkologie.
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#1Arina Riabinska (University of Cologne)H-Index: 5
#2Daria Lehrmann (University of Cologne)
Last. Hans Christian Reinhardt (University of Cologne)H-Index: 11
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The proximal DNA damage response kinase ATM is frequently inactivated in human malignancies. Germline mutations in the ATM gene cause Ataxia-telangiectasia (A-T), characterized by cerebellar ataxia and cancer predisposition. Whether ATM deficiency impacts on tumor initiation or also on the maintenance of the malignant state is unclear. Here, we show that Atm reactivation in initially Atm-deficient B- and T cell lymphomas induces tumor regression. We further find a reduced T cell abundance in B c...
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Abstract Introduction Multiparametric magnetic resonance imaging (mpMRI)/ultrasound fusion-guided biopsy, in short “targeted biopsy (TB)”, is becoming more attractive as it improves the detection of clinically significant prostate cancer (CaP). The accuracy of fusion-guided biopsies is limited due to false positive radiological findings as well as to histological evidence for cancer in radiologically inconspicuous regions of the prostate. We aimed to analyze histomorphological findings on mpMRI ...
1 CitationsSource
#1Marie C. HupeH-Index: 5
#2Anne OffermannH-Index: 8
Last. Sven PernerH-Index: 43
view all 5 authors...
181Background: Biallelic loss of CDK12 has recently been identified as a novel subtype of prostate cancer (PCa). CDK12 altered PCa associates with elevated neoantigen burden and thus may be suitabl...
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#1Anne OffermannH-Index: 8
#2Marie C. HupeH-Index: 5
Last. Sven PernerH-Index: 43
view all 8 authors...
Die Informationen aus pathologischen Befundberichten zu Prostatastanzbiopsien stellen im Management des Prostatakarzinoms einen essentiellen Bestandteil fur die Risikostratifizierung dar. Durch zusatzliche Parameter ist der Informationsgehalt der Befunde zunehmend komplexer geworden. Mit Hilfe einer reprasentativen Umfrage zu pathologischen Befundberichten von Prostatastanzbiopsien sollte ermittelt werden, wie diese von Urologen interpretiert und fur Therapieentscheidungen berucksichtigt werden....
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