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Markus J. Seibel
University of Sydney
414Publications
67H-index
13.6kCitations
Publications 414
Newest
Hong Zhou37
Estimated H-index: 37
,
Mark S. Cooper30
Estimated H-index: 30
,
Markus J. Seibel67
Estimated H-index: 67
Published on Apr 12, 2019in Scientific Reports 4.01
Christinna V. Jørgensen2
Estimated H-index: 2
(UCPH: University of Copenhagen),
Sylvia J. Gasparini4
Estimated H-index: 4
(USYD: University of Sydney)
+ 3 AuthorsHans Bräuner-Osborne42
Estimated H-index: 42
(UCPH: University of Copenhagen)
The G protein-coupled receptor class C, group 6, subtype A (GPRC6A) is suggested to have a physiological function in glucose and bone metabolism, although the precise role lacks consensus due to varying findings in different knockout (KO) mouse models and inconsistent findings on the role of osteocalcin, a proposed GPRC6A agonist. We have further characterized a full locus GPRC6A KO model with respect to energy metabolism, including a long-term high-dose glucocorticoid metabolic challenge. Addit...
David Scott83
Estimated H-index: 83
(Monash University, Clayton campus),
Markus J. Seibel67
Estimated H-index: 67
(USYD: University of Sydney)
+ -3 AuthorsVasant Hirani19
Estimated H-index: 19
(USYD: University of Sydney)
Published in Nutrients 4.17
Rosilene V. Ribeiro1
Estimated H-index: 1
,
Samantha M. Solon-Biet13
Estimated H-index: 13
+ -3 AuthorsFiona Blyth48
Estimated H-index: 48
Protein and branched-chain amino acid (BCAA) intake are associated with changes in circulating BCAAs and influence metabolic health in humans and rodents. However, the relationship between BCAAs and body composition in both species is unclear, with many studies questioning the translatability of preclinical findings to humans. Here, we assessed and directly compared the relationship between circulating BCAAs, body composition, and intake in older mice and men. Body weight and body fat were posit...
Published on May 16, 2019in Diabetologia 7.11
Sylvia J. Gasparini4
Estimated H-index: 4
,
Michael M. Swarbrick8
Estimated H-index: 8
+ 7 AuthorsHong Zhou37
Estimated H-index: 37
Aims/hypothesis Chronic glucocorticoid therapy causes insulin resistance, dyslipidaemia, abnormal fat accumulation, loss of muscle mass and osteoporosis. Here we describe a hitherto unknown sexual dimorphism in the metabolic response to chronic glucocorticoid exposure in mice. This led us to investigate whether glucocorticoid-induced insulin resistance and obesity were dependent on sex hormones.
Published on Apr 29, 2019in Calcified Tissue International 3.27
Jay Pandya , Kirtan Ganda6
Estimated H-index: 6
+ 1 AuthorsMarkus J. Seibel67
Estimated H-index: 67
Secondary fracture prevention programs mostly identify patients with symptomatic non-vertebral fractures, whereas asymptomatic vertebral fractures are usually missed. We here describe the development and validation of a simple method to systematically identify patients with radiographic vertebral fractures using simple text-based searching of free-text radiology reports. The study consisted of two phases. In the development phase (DP), twelve search terms were used to identify vertebral fracture...
Published on Apr 17, 2019in Journal of Bone and Mineral Research 5.71
Konstantin Horas7
Estimated H-index: 7
(USYD: University of Sydney),
Yu Zheng13
Estimated H-index: 13
(USYD: University of Sydney)
+ 10 AuthorsMichelle M. McDonald21
Estimated H-index: 21
(Garvan Institute of Medical Research)
Published on Jun 1, 2019in Osteoarthritis and Cartilage 4.88
Jinwen Tu5
Estimated H-index: 5
(USYD: University of Sydney),
Peng Zhang (SJTU: Shanghai Jiao Tong University)+ 8 AuthorsMarkus J. Seibel67
Estimated H-index: 67
(USYD: University of Sydney)
Summary Objective Aging is a major risk factor for osteoarthritis (OA). Skeletal expression and activity of the glucocorticoid-activating enzyme 11β-hydroxysteroid-dehydrogenase type 1 increases progressively with age in humans and rodents. Here we investigated the role of endogenous osteocytic and osteoblastic glucocorticoid (GC) signalling in the development of osteoarthritic bone and cartilage damage in mice. Methods We utilized transgenic (tg) mice in which glucocorticoid signalling is disru...
David Scott83
Estimated H-index: 83
(Monash University, Clayton campus),
Markus J. Seibel67
Estimated H-index: 67
(USYD: University of Sydney)
+ 6 AuthorsVasant Hirani19
Estimated H-index: 19
(USYD: University of Sydney)
Benjumin Hsu8
Estimated H-index: 8
(USYD: University of Sydney),
Vasant Hirani19
Estimated H-index: 19
(USYD: University of Sydney)
+ 7 AuthorsDavid G. Le Couteur52
Estimated H-index: 52
(USYD: University of Sydney)
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