Markus J. Seibel
University of Sydney
Publications 419
#1David J. Handelsman (USYD: University of Sydney)H-Index: 79
#2Reena Desai (USYD: University of Sydney)H-Index: 12
Last.Robert G. Cumming (USYD: University of Sydney)H-Index: 80
view all 5 authors...
Abstract Long-term studies investigating hormone-dependent cancers and reproductive health often require prolonged frozen storage of serum which assumes that the steroid molecules and measurements are stable over that time. Previous studies of reproducibility of circulating steroids have relied upon flawed historical rather than contemporaneous controls. We measured serum testosterone (T), dihydrotestosterone (DHT), estradiol (E2) and estrone (E1) in 150 randomly selected serum samples by liquid...
#1Fredrick Clive Wright (USYD: University of Sydney)H-Index: 3
#2Sachiko Takehara (USYD: University of Sydney)
Last.Robert G. Cumming (USYD: University of Sydney)H-Index: 80
view all 11 authors...
#1Hong Zhou (USYD: University of Sydney)H-Index: 38
#2Mark S. Cooper (USYD: University of Sydney)H-Index: 32
Last.Markus J. Seibel (USYD: University of Sydney)H-Index: 70
view all 3 authors...
Abstract Glucocorticoids are widely used for their unsurpassed antiinflammatory and immunomodulatory effects. While these beneficial effects can hardly be overestimated, the therapeutic use of glucocorticoids is almost always limited by significant adverse outcomes such as osteoporosis, diabetes, and abnormal fat accrual. In order to understand the pathogenesis of glucocorticoid-induced osteoporosis, it is important to realize that the actions of glucocorticoids on bone and mineral metabolism ar...
#1Christinna V. Jørgensen (UCPH: University of Copenhagen)H-Index: 2
#2Sylvia J. Gasparini (USYD: University of Sydney)H-Index: 4
Last.Hans Bräuner-Osborne (UCPH: University of Copenhagen)H-Index: 43
view all 6 authors...
The G protein-coupled receptor class C, group 6, subtype A (GPRC6A) is suggested to have a physiological function in glucose and bone metabolism, although the precise role lacks consensus due to varying findings in different knockout (KO) mouse models and inconsistent findings on the role of osteocalcin, a proposed GPRC6A agonist. We have further characterized a full locus GPRC6A KO model with respect to energy metabolism, including a long-term high-dose glucocorticoid metabolic challenge. Addit...
#1Mavil May C Cervo (Monash University, Clayton campus)H-Index: 1
#2David Scott (Monash University, Clayton campus)H-Index: 86
Last.Vasant Hirani (USYD: University of Sydney)H-Index: 20
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#1Tadashi Toyama (Kanazawa University)H-Index: 16
#2Oliver van den Broek-Best (USYD: University of Sydney)H-Index: 1
Last.Amanda Y. Wang (The George Institute for Global Health)H-Index: 6
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#1Jinwen Tu (USYD: University of Sydney)H-Index: 5
#2Peng Zhang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last.Hong Zhou (USYD: University of Sydney)H-Index: 38
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Summary Objective Aging is a major risk factor for osteoarthritis (OA). Skeletal expression and activity of the glucocorticoid-activating enzyme 11β-hydroxysteroid-dehydrogenase type 1 increases progressively with age in humans and rodents. Here we investigated the role of endogenous osteocytic and osteoblastic glucocorticoid (GC) signalling in the development of osteoarthritic bone and cartilage damage in mice. Methods We utilized transgenic (tg) mice in which glucocorticoid signalling is disru...
2 CitationsSource
#1Owen Cronin (Western General Hospital)H-Index: 1
#2Laura Forsyth (Edin.: University of Edinburgh)H-Index: 1
Last.Stuart H. Ralston (Edin.: University of Edinburgh)H-Index: 86
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Introduction Paget’s disease of bone (PDB) is characterised by increased and disorganised bone remodelling affecting one or more skeletal sites. Complications include bone pain, deformity, deafness and pathological fractures. Mutations in sequestosome-1 (SQSTM1) are strongly associated with the development of PDB. Bisphosphonate therapy can improve bone pain in PDB, but there is no evidence that treatment alters the natural history of PDB or prevents complications. The Zoledronate in the Prevent...
1 CitationsSource
#1J Tran (CRGH: Concord Repatriation General Hospital)
#2Fac Wright (CRGH: Concord Repatriation General Hospital)H-Index: 3
Last.Robert G. Cumming (USYD: University of Sydney)H-Index: 80
view all 14 authors...
#1Konstantin Horas (USYD: University of Sydney)H-Index: 8
#2Yu Zheng (USYD: University of Sydney)H-Index: 13
Last.Markus J. Seibel (USYD: University of Sydney)H-Index: 70
view all 13 authors...
1 CitationsSource