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Carmen Luisa Arocha-Piñango
Venezuelan Institute for Scientific Research
FibrinogenLonomia obliquaFibrinBiochemistryMedicine
66Publications
17H-index
1,724Citations
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Publications 65
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Patients envenomed by Lonomia sp caterpillars initially experience a mild burning pain, headache, nausea, vomiting, and skin and mucosal hemorrhages. Some patients can rapidly progress to a severe coagulopathy that presents as visceral or intracerebral hemorrhaging. We studied the hemostatic alterations that occurred in 14 patients who were envenomed by Lonomia obliqua in Southern Brazil and presented at the Hospital Sao Vicente de Paulo (Passo Fundo, RS), Brazil during the summers of 1993 and 1...
3 CitationsSource
#1Peter Taylor (IVIC: Venezuelan Institute for Scientific Research)H-Index: 15
#2Emelyn Salazar (IVIC: Venezuelan Institute for Scientific Research)H-Index: 1
Last. Belsy Guerrero (IVIC: Venezuelan Institute for Scientific Research)H-Index: 17
view all 9 authors...
Abstract Introduction Contact with the caterpillar of Lonomia achelous causes a hemorrhagic syndrome in humans prompted by two processes, an initial mild DIC that is later masked by overwhelming fibrinolytic activity. Although the venom affects both the hemostatic and inflammatory systems separately, it is not clear whether the hematological and hemostatic disturbances may in part be due to an indirect effect via inflammatory mediators. Here we report results on the crosstalk between these syste...
1 CitationsSource
Persons who have been in contact with Lonomia achelous or Lonomia obliqua caterpillars present external and internal bleeding and opening of recently healed wounds. Hematological tests show normal platelet count, prolonged prothrombin time, activated partial thromboplastin time and thrombin time, totally corrected by normal plasma. Decreased fibrinogen (Fg), factor (F) V, FXIII, plasminogen and · 2-antiplasmin with increased FVIII: C, von Willebrand factor, Fg degradation products and D dimers. ...
#1Josmary Brazón (IVIC: Venezuelan Institute for Scientific Research)H-Index: 4
#2Belsy Guerrero (IVIC: Venezuelan Institute for Scientific Research)H-Index: 17
Last. Carmen Luisa Arocha-Piñango (IVIC: Venezuelan Institute for Scientific Research)H-Index: 17
view all 5 authors...
Several fibrin(ogen)olytic enzymes from Tityus discrepans (Buthidae, Buthoidea) venom (TdV) were partially purified on a Sephadex G-50 column, by affinity and molecular exclusion high-performance chromatography. Fractions SB1-I and SB1-II had fibrinolytic, fibrinogenolytic (Aα-chains degradation) and tissue plasminogen activator (t-PA)-like activities. SB1-III was only fibrinogenolytic (fast degradation of Aα-chains and slower degradation of fibrinogen Bβ-chains). These results showed the presen...
9 CitationsSource
#1Josmary BrazónH-Index: 3
#2Belsy GuerreroH-Index: 17
view all 5 authors...
Tityus discrepans venom (TdV) produces a variety of haemostatic manifestations including alveoli fibrin deposition and/or prothrombin and partial thromboplastin time (PT, PTT) alterations in mammals. In vitro studies have demonstrated that TdV contains tissue plasminogen activator-like (t-PA), fibrinolytic and plasmin inhibitory compounds and produces platelets activation through GPVI and a novel Src-dependent signalling pathway. The aim of this study is to describe the initial characterization ...
#1Merlyn Vívenes (UDO: Universidad de Oriente)H-Index: 1
#2Dinorah Castro de Guerra (IVIC: Venezuelan Institute for Scientific Research)H-Index: 8
Last. Belsy Guerrero (IVIC: Venezuelan Institute for Scientific Research)H-Index: 17
view all 5 authors...
Abstract Introduction The single nucleotide polymorphism Val35Leu has been described within the A subunit of gene Factor XIII (FXIII-A) in association with an increase of FXIII activity. In the gene's promoter region STR F13A01 is present, however there is no available data related about its influence on the expression of FXIII. Materials and Methods Blood samples were obtained from apparently healthy and unrelated biologically individuals from northeastern area of Venezuela. The system Val35Leu...
1 CitationsSource
#1Mariana Barrios (IVIC: Venezuelan Institute for Scientific Research)H-Index: 2
#2Peter Taylor (IVIC: Venezuelan Institute for Scientific Research)H-Index: 15
Last. Belsy Guerrero (IVIC: Venezuelan Institute for Scientific Research)H-Index: 17
view all 10 authors...
A mouse model was established to reproduce the haemorrhagic syndrome which occurs in humans after accidental contact with the hairs of the caterpillar Lonomia achelous (LA) and measures the haemostatic and inflammatory alterations that occur as a result of this contact. Mice were injected intradermally with different doses (0.4, 0.8 and 1.6 mg/animal) of L. achelous haemolymph (LAH). Haematological (haemoglobin, haematocrit, platelet count, differential leukocyte count), haemostatic (fibrinogen,...
2 CitationsSource
#1Belsy Guerrero (IVIC: Venezuelan Institute for Scientific Research)H-Index: 17
#2Carmen Luisa Arocha-Piñango (IVIC: Venezuelan Institute for Scientific Research)H-Index: 17
Last. Sara Lucena (IVIC: Venezuelan Institute for Scientific Research)H-Index: 4
view all 7 authors...
This work was funded by a grant from the Science and Technology Fund (FONACIT) programs (PG-2005000400), and by the Venezuelan Institute of Scientific Research (IVIC), Caracas, Venezuela.
4 CitationsSource
#1Josmary Brazón (IVIC: Venezuelan Institute for Scientific Research)H-Index: 4
#2Gina D'Suze (IVIC: Venezuelan Institute for Scientific Research)H-Index: 17
Last. Belsy Guerrero (IVIC: Venezuelan Institute for Scientific Research)H-Index: 17
view all 5 authors...
Tityus discrepans venom (TdV) produces digestive hemorrhages, disseminated intravascular coagulation, alveoli fibrin deposition and/or prothrombin and partial thromboplastin time alterations in humans. T. discrepans venom presents an in vitro tissue plasminogen activator-like (tPA-like), fibrino(geno)lytic and plasmin inhibitory activities. The plasmin inhibitor, called discreplasminin, was isolated from TdV. Discreplasminin has a pI of 8.0 and a relative molecular weight of <6,000 Da. Discrepla...
17 CitationsSource
#1Manuel Da Silva (IVIC: Venezuelan Institute for Scientific Research)H-Index: 1
#2Sara Lucena (IVIC: Venezuelan Institute for Scientific Research)H-Index: 4
Last. Belsy Guerrero (IVIC: Venezuelan Institute for Scientific Research)H-Index: 17
view all 10 authors...
Abstract Disintegrins have been previously described in the venom of several snake families inhibiting signal transduction, cell-cell interactions, and cell-matrix interactions and may have therapeutic potential in heart attacks, thrombotic diseases, and cancers. This investigation describes the first disintegrin isolated from South American Crotalus venom (Venezuelan rattlesnake Crotalus durissus cumanensis) , which inhibits platelet adhesion to matrix proteins. C. d. cumanensis crude venom was...
20 CitationsSource
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