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David A. Tuveson
Cold Spring Harbor Laboratory
CancerPancreatic cancerAdenocarcinomaCancer researchBiology
302Publications
73H-index
36.3kCitations
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Publications 294
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#1Aneesha Dasgupta (UNMC: University of Nebraska Medical Center)H-Index: 6
#2Surendra K. Shukla (Eppley Institute for Research in Cancer and Allied Diseases)H-Index: 15
Last. Ravi Thakur (Eppley Institute for Research in Cancer and Allied Diseases)
view all 30 authors...
: Approximately one third of cancer patients die due to complexities related to cachexia. However, the mechanisms of cachexia and the potential therapeutic interventions remain poorly studied. We observed a significant positive correlation between SIRT1 expression and muscle fiber cross-sectional area in pancreatic cancer patients. Rescuing Sirt1 expression by exogenous expression or pharmacological agents reverted cancer cell-induced myotube wasting in culture conditions and mouse models. RNA-s...
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#1Tobias Janowitz (CSHL: Cold Spring Harbor Laboratory)H-Index: 13
#2Eva Gablenz (Heidelberg University)
Last. David A. Tuveson (CSHL: Cold Spring Harbor Laboratory)H-Index: 73
view all 7 authors...
Objective Treatment options for non-hospitalised patients with coronavirus disease 2019 (COVID-19) to reduce morbidity, mortality and spread of the disease are an urgent global need. The over-the-counter histamine-2 receptor antagonist famotidine is a putative therapy for COVID-19. We quantitively assessed longitudinal changes in patient reported outcome measures in non-hospitalised patients with COVID-19 who self-administered high-dose famotidine orally. Design Patients were enrolled consecutiv...
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#1Chong-Feng Gao (Van Andel Institute)H-Index: 8
#2Luke Wisniewski (Van Andel Institute)H-Index: 1
Last. Mirna Kheir Gouda (CSHL: Cold Spring Harbor Laboratory)
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Background and Aims: A subset of pancreatic ductal adenocarcinomas (PDACs) is highly resistant to systemic chemotherapy, but no markers are available in clinical settings to identify this subset. We hypothesized that chemotherapy-resistant PDACs express a glycan biomarker called sTRA. Methods. We tested this marker to identify treatment-resistant PDAC in multiple systems: sets of cell lines, organoids, and isogenic cell lines; primary tumors; and blood plasma from cohorts of human subjects. Resu...
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#1Giulia BiffiH-Index: 10
#2David A. Tuveson (CSHL: Cold Spring Harbor Laboratory)H-Index: 73
Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite the presence of non-neoplastic stromal components that substantially contribute to the...
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#1Daniel E. Freedberg (NewYork–Presbyterian Hospital)H-Index: 2
#2Joseph Conigliaro (Hofstra University)H-Index: 33
Last. Aakriti Gupta (NewYork–Presbyterian Hospital)H-Index: 1
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2 CitationsSource
#1Tobias Janowitz (CSHL: Cold Spring Harbor Laboratory)H-Index: 13
#2David A. Tuveson (CSHL: Cold Spring Harbor Laboratory)H-Index: 73
The coronavirus SARS-CoV-2 has created a global pandemic that has killed more than a quarter million people since December 2019, halted commerce, and disrupted our ability to research cancer in the laboratory and clinic and care for our patients. A return toward a functioning society can be facilitated by the active participation of cancer researchers to diagnose and treat SARS-CoV-2 infected patients, and the direct and indirect benefits of our involvement cannot be overstated.
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#1Pippa Corrie (Cambridge University Hospitals NHS Foundation Trust)H-Index: 30
#2Wendi Qian (Cambridge University Hospitals NHS Foundation Trust)H-Index: 37
Last. Jonathan Wadsley (Weston Park Hospital)H-Index: 21
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Nab-paclitaxel plus gemcitabine (nabP+gemcitabine) offers modest survival gains for patients with metastatic pancreatic ductal adenocarcinoma (PDAC). Sequential scheduling of nabP+gemcitabine in a PDAC mouse model improved efficacy; this hypothesis was tested in a clinical trial. Patients with previously untreated metastatic PDAC were randomised to receive nabP+gemcitabine administered either concomitantly on the same day, or sequentially, with gemcitabine administered 24 h after nabP. The prima...
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#1Tim D.D. Somerville (CSHL: Cold Spring Harbor Laboratory)H-Index: 6
#2Giulia Biffi (University of Cambridge)H-Index: 10
Last. Olaf Klingbeil (CSHL: Cold Spring Harbor Laboratory)H-Index: 3
view all 16 authors...
A highly aggressive subset of pancreatic ductal adenocarcinomas undergo trans-differentiation into the squamous lineage during disease progression. Here, we investigated whether squamous trans-differentiation of human and mouse pancreatic cancer cells can influence the phenotype of non-neoplastic cells in the tumor microenvironment. Conditioned media experiments revealed that squamous pancreatic cancer cells secrete factors that recruit neutrophils and convert pancreatic stellate cells into canc...
1 CitationsSource
#1Michelle Monje (Stanford University)H-Index: 35
#2Jeremy C Borniger (CSHL: Cold Spring Harbor Laboratory)H-Index: 1
Last. Douglas Hanahan (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 57
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Mounting evidence indicates that the nervous system plays a central role in cancer pathogenesis. In turn, cancers and cancer therapies can alter nervous system form and function. This Commentary seeks to describe the burgeoning field of "cancer neuroscience" and encourage multidisciplinary collaboration for the study of cancer-nervous system interactions.
1 CitationsSource
#1Tim D.D. Somerville (CSHL: Cold Spring Harbor Laboratory)H-Index: 6
#2Giulia Biffi (University of Cambridge)H-Index: 10
Last. Olaf Klingbeil (CSHL: Cold Spring Harbor Laboratory)H-Index: 3
view all 16 authors...
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