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Nele Vandeputte
Katholieke Universiteit Leuven
ImmunologyThrombotic thrombocytopenic purpuraVon Willebrand factorADAMTS13Medicine
32Publications
11H-index
538Citations
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Publications 32
Newest
#1Shannen Deconinck (Katholieke Universiteit Leuven)H-Index: 1
#2Claudia Tersteeg (Katholieke Universiteit Leuven)H-Index: 13
Last. Marc VanderheydenH-Index: 42
view all 10 authors...
Source
#1Sirima Kraisin (Katholieke Universiteit Leuven)H-Index: 1
#2Sebastien Verhenne (Katholieke Universiteit Leuven)H-Index: 6
Last. Simon F. De Meyer (Katholieke Universiteit Leuven)H-Index: 24
view all 10 authors...
BACKGROUND: Malaria-associated acute respiratory distress syndrome (MA-ARDS) is a lethal complication of severe malaria, characterized by marked pulmonary inflammation. Patient studies have suggested a link between von Willebrand factor (VWF) and malaria severity. OBJECTIVES: To investigate the role of VWF in the pathogenesis of experimental MA-ARDS. METHODS: Plasmodium berghei NK65-E (PbNK65) parasites were injected in Vwf+/+ and Vwf-/- mice. Pathological parameters were assessed following infe...
3 CitationsSource
#1An-Sofie Schelpe (Katholieke Universiteit Leuven)H-Index: 4
#2Anastasis Petri (Imperial College London)H-Index: 2
Last. Karen Vanhoorelbeke (Katholieke Universiteit Leuven)H-Index: 38
view all 7 authors...
Source
#1Elien Roose (Katholieke Universiteit Leuven)H-Index: 7
#2An-Sofie Schelpe (Katholieke Universiteit Leuven)H-Index: 4
Last. Karen Vanhoorelbeke (Katholieke Universiteit Leuven)H-Index: 38
view all 21 authors...
Source
#1Irina Portier (Katholieke Universiteit Leuven)H-Index: 2
#2Kimberly Martinod (Katholieke Universiteit Leuven)H-Index: 23
Last. Simon F. De Meyer (Katholieke Universiteit Leuven)H-Index: 13
view all 7 authors...
Abdominal aortic aneurysm (AAA) refers to a localized dilation of the abdominal aorta that exceeds the normal diameter by 50%. AAA pathophysiology is characterized by progressive inflammation, vessel wall destabilization and thrombus formation. Our aim was to investigate the potential involvement of von Willebrand factor (VWF), a thrombo-inflammatory plasma protein, in AAA pathophysiology using a dissection-based and angiotensin II infusion-induced AAA mouse model. AAA formation was induced in b...
1 CitationsSource
#1Shannen Deconinck (Katholieke Universiteit Leuven)H-Index: 1
#2Claudia Tersteeg (Katholieke Universiteit Leuven)H-Index: 13
Last. Karen Vanhoorelbeke (Katholieke Universiteit Leuven)H-Index: 38
view all 11 authors...
Background: Patients with von Willebrand disease (VWD) type 2A or acquired von Willebrand syndrome (aVWS) as a consequence of implantation of left ventricular assist devices (LVAD) are both characterized by a loss of von Willebrand factor (VWF) function. Loss of VWF function is however more severe in VWD type 2A than in LVAD patients. Objectives: To compare VWF function in patients with VWD type 2A and LVAD-induced aVWS to highlight the differences in VWF activity and to stress the importance of...
2 CitationsSource
#1Elien Roose (Katholieke Universiteit Leuven)H-Index: 7
#2Gestur Vidarsson (UvA: University of Amsterdam)H-Index: 8
Last. Karen Vanhoorelbeke (Katholieke Universiteit Leuven)H-Index: 38
view all 20 authors...
Immune-mediated thrombotic thrombocytopenic purpura (iTTP) is characterized by severe ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeats, member 13) deficiency, the presence of anti-ADAMTS13 autoantibodies and an open ADAMTS13 conformation with a cryptic epitope in the spacer domain exposed. A detailed knowledge of anti-ADAMTS13 autoantibodies will help identifying pathogenic antibodies and elucidating the cause of ADAMTS13 deficiency. We aimed at cloning anti-ADAMTS1...
3 CitationsSource
#1Shannen Deconinck (Katholieke Universiteit Leuven)H-Index: 1
#2C Terseeg (Katholieke Universiteit Leuven)
Last. Marc VanderheydenH-Index: 42
view all 9 authors...
Source
#1An-Sofie Schelpe (Katholieke Universiteit Leuven)H-Index: 4
#2Christelle OrlandoH-Index: 2
Last. Kristin JochmansH-Index: 13
view all 14 authors...
Introduction: Patients suffering from congenital thrombotic thrombocytopenic purpura (cTTP) have a deficiency in ADAMTS13 due to mutations in their ADAMTS13 gene. Objective: The aim of this study was to determine ADAMTS13 parameters (activity, antigen, and mutations), to investigate if the propositus suffered from child-onset cTTP, and to study the in vitro effect of the ADAMTS13 mutations. Methods: ADAMTS13 activity and antigen were determined using the FRETS VWF73 assay and ELISA and ADAMTS13 ...
Source
#1Irina Portier (Katholieke Universiteit Leuven)H-Index: 2
#2Karen Vanhoorelbeke (Katholieke Universiteit Leuven)H-Index: 38
Last. Simon F. DeMeyer (Katholieke Universiteit Leuven)H-Index: 22
view all 12 authors...
BACKGROUND: Type 3 von Willebrand disease (VWD) is characterized by complete absence of von Willebrand factor (VWF). Current therapy is limited to treatment with exogenous VWF/FVIII products, which only provide a short-term solution. Gene therapy offers the potential for a long-term treatment for VWD. OBJECTIVES: To develop an integrative Sleeping Beauty (SB) transposon-mediated VWF gene transfer approach in a preclinical mouse model of severe VWD. METHODS: We established a robust platform for s...
6 CitationsSource
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