Fredrik Lanner
Karolinska Institutet
48Publications
19H-index
1,769Citations
Publications 48
Newest
Published on Jan 22, 2018in Journal of Visualized Experiments 1.18
Sandra Petrus-Reurer3
Estimated H-index: 3
(Karolinska Institutet),
Hammurabi Bartuma4
Estimated H-index: 4
(Karolinska Institutet)
+ 3 AuthorsAnders Kvanta24
Estimated H-index: 24
(Karolinska Institutet)
Geographic atrophy (GA), the late stage of dry age-related macular degeneration is characterized by loss of the retinal pigment epithelial (RPE) layer, which leads to subsequent degeneration of vital retinal structures (e.g., photoreceptors) causing severe vision impairment. Similarly, RPE-loss and decrease in visual acuity is seen in long-term follow up of patients with advanced wet age-related macular degeneration (AMD) receiving intravitreal anti-vascular endothelial growth factor (VEGF) trea...
1 Citations Source Cite
Published on Oct 1, 2018in Current Opinion in Genetics & Development 5.00
Nicolás M Ortega (Karolinska Institutet), Nerges Winblad1
Estimated H-index: 1
(Karolinska Institutet)
+ 1 AuthorsFredrik Lanner19
Estimated H-index: 19
(Karolinska Institutet)
Understanding the genetic underpinning of early human development is of great interest not only for basic developmental and stem cell biology but also for regenerative medicine, infertility treatments, and better understanding the causes of congenital disease. Our current knowledge has mainly been generated with the use of laboratory animals, especially the mouse. While human and mouse early development present morphological resemblance, we know that the timing of the events as well as the cellu...
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Published on Jul 13, 2018in Investigative Ophthalmology & Visual Science 3.39
Sandra Petrus-Reurer3
Estimated H-index: 3
(Karolinska Institutet),
Laia Gorchs2
Estimated H-index: 2
(Karolinska Institutet)
+ 9 AuthorsHelen Kaipe6
Estimated H-index: 6
(Karolinska Institutet)
Published on Jul 13, 2018in Investigative Ophthalmology & Visual Science 3.39
Sara Padrell Sánchez1
Estimated H-index: 1
(Karolinska Institutet),
Sandra Petrus-Reurer3
Estimated H-index: 3
(Karolinska Institutet)
+ 3 AuthorsFredrik Lanner19
Estimated H-index: 19
(Karolinska Institutet)
Published on Jan 1, 2018in Developmental Biology 3.26
Olga Tšuiko2
Estimated H-index: 2
(University of Tartu),
Tatjana Jatsenko1
Estimated H-index: 1
+ 5 AuthorsAndres Salumets21
Estimated H-index: 21
Abstract The journey of embryonic development starts at oocyte fertilization, which triggers a complex cascade of events and cellular pathways that guide early embryogenesis. Recent technological advances have greatly expanded our knowledge of cleavage-stage embryo development, which is characterized by an increased rate of whole-chromosome losses and gains, mixoploidy, and atypical cleavage morphokinetics. Embryonic aneuploidy significantly contributes to implantation failure, spontaneous misca...
1 Citations Source Cite
Published on Aug 1, 2018in Cell Stem Cell 23.29
Alvaro Plaza Reyes5
Estimated H-index: 5
(Karolinska Institutet),
Fredrik Lanner19
Estimated H-index: 19
(Karolinska Institutet)
Although endonuclease-mediated genome editing techniques offer significant improvement over traditional methods, they are still ineffective for introduction of large DNA sequences. Recently in Nature Biotechnology , Gu et al. (2018) developed a CRISPR-Cas strategy termed 2C-HR-CRISPR that generates fluorescent reporter tagging of genes with up to 95% knockin efficiency in mouse embryos.
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Published on Jan 1, 2017in Development 5.41
Alvaro Plaza Reyes5
Estimated H-index: 5
(Karolinska Institutet),
Fredrik Lanner19
Estimated H-index: 19
(Karolinska Institutet)
Developmental biologists have become increasingly aware that the wealth of knowledge generated through genetic studies of pre-implantation mouse development might not easily be translated to the human embryo. Comparative studies have been fueled by recent technological advances in single-cell analysis, allowing in-depth analysis of the human embryo. This field could shortly gain more momentum as novel genome editing technologies might, for the first time, also allow functional genetic studies in...
12 Citations Source Cite
Published on Feb 22, 2017in eLife 7.62
Eszter Posfai4
Estimated H-index: 4
,
Sophie Petropoulos6
Estimated H-index: 6
(Karolinska Institutet)
+ 5 AuthorsJanet Rossant120
Estimated H-index: 120
(University of Toronto)
In female mammals, conception is a complex process that involves several stages. First, an egg is released from the ovary and travels along a tube called the oviduct, where sperm from a male may fertilize it. If the egg is fertilized, the newly formed embryo moves into the womb, where it will then implant into the walls. In mice, it takes around four days for the embryo to implant and during this time, the cells in the embryo divide several times and start to specialize to form distinct cell typ...
22 Citations Source Cite
Published on Feb 23, 2017in Investigative Ophthalmology & Visual Science 3.39
Sandra Petrus-Reurer3
Estimated H-index: 3
(Karolinska Institutet),
Hammurabi Bartuma4
Estimated H-index: 4
(Karolinska Institutet)
+ 4 AuthorsAnders Kvanta24
Estimated H-index: 24
(Karolinska Institutet)
Subretinal suspension transplants of human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) have the capacity to form functional monolayers in naive eyes. We explore hESC-RPE integration when transplanted in suspension to a large-eyed model of geographic atrophy (GA).Derivation of hESC-RPE was performed in a xeno-free and defined manner. Subretinal bleb injection of PBS or sodium iodate (NaIO3) was used to induce a GA-like phenotype. Suspensions of hESC-RPE were transplant...
7 Citations Source Cite
Published on May 1, 2017in Cell Reports 8.03
Ursula Nosi2
Estimated H-index: 2
(University of Toronto),
Fredrik Lanner19
Estimated H-index: 19
(Karolinska Institutet)
+ 1 AuthorsBrian J. Cox47
Estimated H-index: 47
(University of Toronto)
Summary The first cell fate choice of the preimplantation embryo generates the extraembryonic trophoblast and embryonic epiblast lineages. Embryonic stem cells (ESCs) and trophoblast stem cells (TSCs) can be utilized to investigate molecular mechanisms of this first cell fate decision. It has been established that ESCs can be induced to acquire trophoblast lineage characteristics upon manipulation of lineage-determining transcription factors. Here, we have interrogated the potential of microRNAs...
6 Citations Source Cite
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