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Fredrik Lanner
Karolinska Institutet
52Publications
20H-index
1,860Citations
Publications 52
Newest
Published on Apr 9, 2019in Nature Communications 12.35
Eleni Gelali1
Estimated H-index: 1
(Science for Life Laboratory),
Gabriele Girelli1
Estimated H-index: 1
(Science for Life Laboratory)
+ 12 AuthorsReza Mirzazadeh1
Estimated H-index: 1
(Science for Life Laboratory)
DNA fluorescence in situ hybridization (DNA FISH) is a powerful method to study chromosomal organization in single cells. At present, there is a lack of free resources of DNA FISH probes and probe design tools which can be readily applied. Here, we describe iFISH, an open-source repository currently comprising 380 DNA FISH probes targeting multiple loci on the human autosomes and chromosome X, as well as a genome-wide database of optimally designed oligonucleotides and a freely accessible web in...
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Published on Jan 1, 2019in Protocol exchange
Nicola Crosetto21
Estimated H-index: 21
,
Magda Bienko8
Estimated H-index: 8
+ 12 AuthorsKatalin Ferenc1
Estimated H-index: 1
1 Citations Source Cite
Published on Oct 1, 2018in Current Opinion in Genetics & Development 5.00
Nicolás M Ortega (Karolinska Institutet), Nerges Winblad1
Estimated H-index: 1
(Karolinska Institutet)
+ 1 AuthorsFredrik Lanner20
Estimated H-index: 20
(Karolinska Institutet)
Understanding the genetic underpinning of early human development is of great interest not only for basic developmental and stem cell biology but also for regenerative medicine, infertility treatments, and better understanding the causes of congenital disease. Our current knowledge has mainly been generated with the use of laboratory animals, especially the mouse. While human and mouse early development present morphological resemblance, we know that the timing of the events as well as the cellu...
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Published on Aug 1, 2018in Cell Stem Cell 23.29
Alvaro Plaza Reyes5
Estimated H-index: 5
(Karolinska Institutet),
Fredrik Lanner20
Estimated H-index: 20
(Karolinska Institutet)
Although endonuclease-mediated genome editing techniques offer significant improvement over traditional methods, they are still ineffective for introduction of large DNA sequences. Recently in Nature Biotechnology , Gu et al. (2018) developed a CRISPR-Cas strategy termed 2C-HR-CRISPR that generates fluorescent reporter tagging of genes with up to 95% knockin efficiency in mouse embryos.
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Published on Jul 13, 2018in Investigative Ophthalmology & Visual Science 3.39
Sandra Petrus-Reurer3
Estimated H-index: 3
(Karolinska Institutet),
Laia Gorchs2
Estimated H-index: 2
(Karolinska Institutet)
+ 9 AuthorsHelen Kaipe6
Estimated H-index: 6
(Karolinska Institutet)
Published on Jul 13, 2018in Investigative Ophthalmology & Visual Science 3.39
Camilla Mohlin7
Estimated H-index: 7
(Linnaeus University),
Sandra Petrus-Reurer3
Estimated H-index: 3
(Karolinska Institutet)
+ 4 AuthorsKristina Nilsson-Ekdahl38
Estimated H-index: 38
(Uppsala University)
Published on Jul 13, 2018in Investigative Ophthalmology & Visual Science 3.39
Sara Padrell Sánchez1
Estimated H-index: 1
(Karolinska Institutet),
Sandra Petrus-Reurer3
Estimated H-index: 3
(Karolinska Institutet)
+ 3 AuthorsFredrik Lanner20
Estimated H-index: 20
(Karolinska Institutet)
Published on Jan 22, 2018in Journal of Visualized Experiments 1.18
Sandra Petrus-Reurer3
Estimated H-index: 3
(Karolinska Institutet),
Hammurabi Bartuma4
Estimated H-index: 4
(Karolinska Institutet)
+ 3 AuthorsAnders Kvanta24
Estimated H-index: 24
(Karolinska Institutet)
Geographic atrophy (GA), the late stage of dry age-related macular degeneration is characterized by loss of the retinal pigment epithelial (RPE) layer, which leads to subsequent degeneration of vital retinal structures (e.g., photoreceptors) causing severe vision impairment. Similarly, RPE-loss and decrease in visual acuity is seen in long-term follow up of patients with advanced wet age-related macular degeneration (AMD) receiving intravitreal anti-vascular endothelial growth factor (VEGF) trea...
1 Citations Source Cite
Published on Jan 1, 2018in Developmental Biology 3.26
Olga Tšuiko2
Estimated H-index: 2
(University of Tartu),
Tatjana Jatsenko1
Estimated H-index: 1
+ 5 AuthorsAndres Salumets24
Estimated H-index: 24
Abstract The journey of embryonic development starts at oocyte fertilization, which triggers a complex cascade of events and cellular pathways that guide early embryogenesis. Recent technological advances have greatly expanded our knowledge of cleavage-stage embryo development, which is characterized by an increased rate of whole-chromosome losses and gains, mixoploidy, and atypical cleavage morphokinetics. Embryonic aneuploidy significantly contributes to implantation failure, spontaneous misca...
1 Citations Source Cite
Published on Dec 1, 2017in Scientific Reports 4.12
Sebastian Hildebrand4
Estimated H-index: 4
(Karolinska Institutet),
Sara Hultin3
Estimated H-index: 3
(Karolinska Institutet)
+ 9 AuthorsArindam Majumdar1
Estimated H-index: 1
(Karolinska Institutet)
Epithelial cells connect via cell-cell junctions to form sheets of cells with separate cellular compartments. These cellular connections are essential for the generation of cellular forms and shape ...
4 Citations Source Cite
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