Match!
Dubravko Jelić
GlaxoSmithKline
55Publications
13H-index
491Citations
Publications 54
Newest
Abstract The human histone demethylases of the KDM4 family have been related to diseases such as prostate and breast cancer. Majority of currently known inhibitors suffer from the low permeability and low selectivity between the enzyme isoforms. In this study, toxoflavin motif was used to design and synthesize new KDM4C inhibitors with improved biological activity and in vitro ADME properties. Inhibitors displayed good passive cellular permeability and metabolic stability. However, diminishing o...
Source
Source
#2Dubravko JelićH-Index: 13
Last.Milan MesicH-Index: 7
view all 7 authors...
Autotaxin (ATX) is an extracellular enzyme that hydrolyses lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), which has a role in the mediation of inflammation, fibrosis and cancer. ATX is a drug target that has been the focus of many research groups during the last ten years. To date, only one molecule, Ziritaxestat (GLPG1690) has entered the clinic; it is currently in Phase 3 clinical trials for idiopathic pulmonary fibrosis. Other small molecules, with different binding modes, have...
Source
#1Marija Kindl (University of Zagreb)H-Index: 5
#2Franz Bucar (University of Graz)H-Index: 28
Last.Sanda Vladimir-Knežević (University of Zagreb)H-Index: 14
view all 6 authors...
The polyphenolic composition and anti-inflammatory activity of selected Thymus species (T. longicaulis C. Presl, T. praecox Opiz subsp. polytrichus (A. Kerner Ex Borbas) Jalas, T. pulegioides L., T. serpyllum L. subsp. serpyllum and T. striatus Vahl) was studied in comparison with T. vulgaris, as an officinal medicinal plant, to evaluate the biomedical potential of these Croatian wild-growing species. This paper provides a first insight into the polyphenolic profiles of T. praecox subsp. polytri...
Source
#1Daniela Jakšić (University of Zagreb)H-Index: 1
#2Sándor Kocsubé (University of Szeged)H-Index: 24
Last.Maja Šegvić Klarić (University of Zagreb)H-Index: 15
view all 10 authors...
Aspergilli section Flavi, originally isolated from air samples collected from inhabited apartments (AP), unoccupied basements (BS), and processing facilities of a grain mill (GM), were analyzed for their potential to produce aflatoxin B1 (AFB1) on solid media. The isolates were further characterized with regard to their cytotoxic, genotoxic, and pro-inflammatory properties in vitro. Aspergilli were identified based on partial calmodulin (CaM) gene sequencing; the producing capacities of isolates...
Source
#1Daniela Jakšić (University of Zagreb)H-Index: 1
#2Sándor Kocsubé (University of Szeged)H-Index: 24
Last.Maja Šegvić Klarić (University of Zagreb)H-Index: 15
view all 10 authors...
This study presents the distribution of fumonisin (FB)-producing and non-producing airborne Aspergilli (Nigri) in apartments (AP), basements (BS) and a grain mill (GM) in Croatia, and their cytotoxic, immunomodulation and genotoxic potency in comparison with FB1 and FB2. Concentration of black Aspergilli was 260-fold higher in GM than in living environment with domination of A. tubingensis and A. welwitschiae. FB2- but not FB1- was confirmed via HPLC-MS and detection of fum1 and fum8 genes for o...
1 CitationsSource
#2Daniela JakšićH-Index: 1
Last.Bojan ŠarkanjH-Index: 11
view all 7 authors...
Source
#1Andrea Hulina (University of Zagreb)H-Index: 3
#2Marija Grdić Rajković (University of Zagreb)H-Index: 5
Last.Lada Rumora (University of Zagreb)H-Index: 13
view all 7 authors...
Extracellular Hsp70 (eHsp70) can act as damage-associated molecular pattern (DAMP) via Toll-like receptors TLR2 and TLR4, and stimulate immune and inflammatory responses leading to sterile inflammation and propagation of already existing inflammation. It was found elevated in the blood of patients with chronic obstructive pulmonary disease (COPD), who might suffer occasional bacterial colonizations and infections. We used a monocytic THP-1 cell line as a cellular model of systemic compartment of...
9 CitationsSource
#1Andrea Hulina (University of Zagreb)H-Index: 3
#2Martina BosnarH-Index: 11
Last.Lada Rumora (University of Zagreb)H-Index: 13
view all 6 authors...
Introduction: Extracellular Hsp70 (eHsp70) was shown to be increased in serum of patients with lung diseases, such as chronic obstructive pulmonary disease (COPD). Some studies demonstrated that eHsp70 can act pro-inflammatory and trigger sterile inflammation via Toll like receptors (TLR) 2 and 4. Aims and objectives: We hypothesized that eHsp70 might induce inflammatory, but not necessarily cytotoxic effects in THP-1 cell line. Therefore, we assess activity of caspases-1, -3/7, -8 and -9 in PMA...
Source
123456