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D. M. Bradburn
Newcastle University
CancerDNA methylationEpigeneticsColorectal cancerMedicine
29Publications
13H-index
653Citations
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Publications 29
Newest
#1Fiona C. MalcomsonH-Index: 3
#2N. D. WillisH-Index: 5
Last. John C. MathersH-Index: 65
view all 9 authors...
2 CitationsSource
#1Khalil ElGendy (Newcastle University)H-Index: 1
#2Fiona C. Malcomson (Newcastle University)H-Index: 3
Last. John C. Mathers (Newcastle University)H-Index: 65
view all 5 authors...
DNA methylation is a key component of the epigenetic machinery that is responsible for regulating gene expression and, therefore, cell function. Patterns of DNA methylation change during development and ageing, differ between cell types, are altered in multiple diseases and can be modulated by dietary factors. However, evidence about the effects of dietary factors on DNA methylation patterns in humans is fragmentary. This study was initiated to collate evidence for causal links between dietary f...
3 CitationsSource
#2N. D. WillisH-Index: 5
Last. John C. MathersH-Index: 65
view all 9 authors...
Source
#1Catherine MéplanH-Index: 21
#2Ian T. Johnson (Norwich Research Park)H-Index: 57
Last. John E. Hesketh (Newcastle University)H-Index: 42
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Epidemiologic studies highlight the potential role of dietary selenium (Se) in colorectal cancer prevention. Our goal was to elucidate whether expression of factors crucial for colorectal homoeostasis is affected by physiologic differences in Se status. Using transcriptomics and proteomics followed by pathway analysis, we identified pathways affected by Se status in rectal biopsies from 22 healthy adults, including 11 controls with optimal status (mean plasma Se = 1.43 μM) and 11 subjects with s...
19 CitationsSource
#1E WalshH-Index: 1
#2C J ReesH-Index: 6
Last. Mark A. HullH-Index: 33
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Are there biological differences between screen-detected and interval colorectal cancers in the English Bowel Cancer Screening Programme?
2 CitationsSource
#1GillH-Index: 2
#2M G BrambleH-Index: 7
Last. C J ReesH-Index: 6
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Screen-detected colorectal cancers are associated with an improved outcome compared with stage-matched interval cancers
23 CitationsSource
#1N. D. Willis (Newcastle University)H-Index: 5
Last. John C. Mathers (Newcastle University)H-Index: 65
view all 9 authors...
Source
Purpose The aims of this study were to investigate the use of quantitative CGI methylation data from stool DNA to classify colon cancer patients and to relate stool CGI methylation levels to those found in corresponding tissue samples.
14 CitationsSource
#1Helen Staley (Newcastle University)
#2D. M. BradburnH-Index: 13
Last. John C. Mathers (Newcastle University)H-Index: 65
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Source
#1Helen Staley (Newcastle University)
#2D. M. BradburnH-Index: 13
Last. John C. Mathers (Newcastle University)H-Index: 65
view all 3 authors...
Source
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