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Ulrike Gewessler
Graz University of Technology
7Publications
4H-index
102Citations
Publications 7
Newest
Published on Mar 1, 2014in New Biotechnology 3.73
Clemens Gamerith4
Estimated H-index: 4
,
Andrea Heinzle6
Estimated H-index: 6
+ 7 AuthorsGeorg Gübitz58
Estimated H-index: 58
(University of Natural Resources and Life Sciences, Vienna)
Bacterial contamination of platelet concentrates (PCs) can lead to fatal transfusion transmitted diseases and is the most abundant infectious risk in transfusion medicine. The storage conditions of PCs provide a good environment for bacterial growth. The detection of these contaminations at an early stage is therefore important to avoid the transfusion of contaminated samples. In this study, bioresponsive polymer (BRP) systems were used for the detection of microorganisms in PCs. The backbone of...
3 Citations Source Cite
Published on May 1, 2013in Annals of Clinical Biochemistry 1.98
Andrea Hasmann8
Estimated H-index: 8
(Graz University of Technology),
Eva Wehrschuetz-Sigl7
Estimated H-index: 7
+ 9 AuthorsBarbara Binder16
Estimated H-index: 16
BackgroundNeutrophilic polymorphonuclear leukocytes play a crucial role in the host defence against bacterial and fungal infections. They participate in the inflammatory response through the liberation of peptides and enzymes like myeloperoxidase (MPO). Therefore, MPO has a potential as a marker enzyme for the diagnosis of wound infection.MethodsSubstrate specificities and reaction pathways of MPO were investigated for new MPO substrates: crystal violet, leuco crystal violet, fast blue RR (4-ben...
24 Citations Source Cite
Published on Sep 1, 2012in New Biotechnology 3.73
Eva Sigl6
Estimated H-index: 6
,
Andrea Heinzle6
Estimated H-index: 6
+ 8 AuthorsMichael V. Schintler14
Estimated H-index: 14
Source Cite
Published on May 1, 2012in New Biotechnology 3.73
Konstantin Schneider13
Estimated H-index: 13
,
Ulrike Gewessler4
Estimated H-index: 4
+ 5 AuthorsGeorg Gübitz58
Estimated H-index: 58
(Graz University of Technology)
Bioresponsive polymers (BRPs) allow the detection of potentially pathogenic microorganisms. Here, peptidoglycan and cellulose based hydrogels were constructed with potential for diagnosis of wound infection or, for example, Aspergillosis, respectively. These systems respond to extracellular enzymes from microbes or enzymes secreted from the human immune system in case of infection. Laccases as ‘enhanzymes’ were incorporated into these devices for signal and stability enhancement when compared to...
12 Citations Source Cite
Published on Sep 1, 2011in Diagnostic Microbiology and Infectious Disease 2.34
Andrea Hasmann8
Estimated H-index: 8
(Graz University of Technology),
Eva Wehrschuetz-Sigl7
Estimated H-index: 7
+ 6 AuthorsGeorg Gübitz58
Estimated H-index: 58
(Graz University of Technology)
Abstract Detection of wound infection is based on evaluation of the well-known signs of inflammation like rubor (redness), calor (heat), tumor (swelling), and dolor (pain) by medical doctors and/or time-consuming procedures requiring special machinery. There is currently no rapid diagnostic device available for the indication of wound infection, which would especially be helpful in home care of chronic ulcer patients. In this study, a new concept for a fast diagnostic tool for wound infection ba...
32 Citations Source Cite
Published on Jun 1, 2011in Experimental Dermatology 2.61
Andrea Hasmann8
Estimated H-index: 8
(Graz University of Technology),
Ulrike Gewessler4
Estimated H-index: 4
+ 8 AuthorsGeorg Gübitz58
Estimated H-index: 58
(Graz University of Technology)
Human neutrophil elastase (HNE) and cathepsin G (CatG) are involved in the pathogenesis of a number of inflammatory disorders. These serine proteinases are released by neutrophils and monocytes in case of infection. Wound infection is a severe complication regarding wound healing causing diagnostic and therapeutic problems. In this study we have shown the potential of HNE and CatG to be used as markers for early detection of infection. Significant differences in HNE and CatG levels in infected a...
31 Citations Source Cite
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