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Fabrizio Tagliavini
Carlo Besta Neurological Institute
383Publications
60H-index
12.1kCitations
Publications 383
Newest
Published on Jan 3, 2019in Acta neuropathologica communications
Giuseppe Di Fede16
Estimated H-index: 16
,
Marcella Catania9
Estimated H-index: 9
+ 19 AuthorsRoberto Testi1
Estimated H-index: 1
Prion diseases are neurodegenerative disorders which are caused by an accumulation of the abnormal, misfolded prion protein known as scrapie prion protein (PrPSc). These disorders are unique as they occur as sporadic, genetic and acquired forms. Sporadic Creutzfeldt-Jakob Disease (CJD) is the most common human prion disease, accounting for approximately 85–90% of cases, whereas autosomal dominant genetic forms, due to mutations in the prion protein gene (PRNP), account for 10–15% of cases. Genet...
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Published on Mar 26, 2019in Scientific Reports 4.01
Ignazio Cali16
Estimated H-index: 16
(Case Western Reserve University),
Jody Lavrich1
Estimated H-index: 1
(Case Western Reserve University)
+ 7 AuthorsSilvio Notari13
Estimated H-index: 13
(Case Western Reserve University)
The presence of abnormal, disease-related prion protein (PrPD) has recently been demonstrated by protein misfolding cyclic amplification (PMCA) in urine of patients affected with variant Creutzfeldt-Jakob disease (vCJD), a prion disease typically acquired from consumption of prion contaminated bovine meat. The complexity and multistage process of urine excretion along with the obligatory use of PMCA raise the issue of whether strain characteristics of the PrPD present in vCJD brains, such as inf...
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Published on Apr 30, 2019in Molecular Neurobiology 4.59
Edoardo Bistaffa3
Estimated H-index: 3
,
Martina Rossi3
Estimated H-index: 3
+ 7 AuthorsFabio Moda13
Estimated H-index: 13
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Published on Apr 1, 2019in Brain 11.81
Henri J. M. M. Mutsaerts11
Estimated H-index: 11
(Sunnybrook Research Institute),
Saira S Mirza (Sunnybrook Research Institute)+ 28 AuthorsAndrew D. Robertson10
Estimated H-index: 10
(Sunnybrook Research Institute)
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Published on Apr 1, 2019in Molecular Neurobiology 4.59
Edoardo Bistaffa3
Estimated H-index: 3
(SISSA: International School for Advanced Studies),
Fabio Moda13
Estimated H-index: 13
+ 7 AuthorsGiuseppe Legname38
Estimated H-index: 38
(SISSA: International School for Advanced Studies)
Prion pathologies are characterized by the conformational conversion of the cellular prion protein (PrPC) into a pathological infectious isoform, known as PrPSc. The latter acquires different abnormal conformations, which are associated with specific pathological phenotypes. Recent evidence suggests that prions adapt their conformation to changes in the context of replication. This phenomenon is known as either prion selection or adaptation, where distinct conformations of PrPSc with higher prop...
2 Citations Source Cite
Published on Mar 25, 2019in Journal of Magnetic Resonance Imaging 3.73
Paolo Vitali21
Estimated H-index: 21
,
Fulvia Palesi7
Estimated H-index: 7
+ 9 AuthorsGiorgio Giaccone47
Estimated H-index: 47
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Published on Mar 1, 2019in Parkinsonism & Related Disorders 4.36
Laura Fadda2
Estimated H-index: 2
,
Raffaella Lombardi24
Estimated H-index: 24
+ 3 AuthorsFabrizio Tagliavini60
Estimated H-index: 60
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Published on Feb 3, 2019in Neuropathology and Applied Neurobiology 6.88
Gianluigi Forloni58
Estimated H-index: 58
,
Roberto Chiesa40
Estimated H-index: 40
+ 2 AuthorsFabrizio Tagliavini60
Estimated H-index: 60
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Published on Feb 1, 2019in Molecular Neurobiology 4.59
Elisa Meneghetti2
Estimated H-index: 2
(SISSA: International School for Advanced Studies),
Lisa Gasperini4
Estimated H-index: 4
(SISSA: International School for Advanced Studies)
+ 4 AuthorsGiuseppe Legname38
Estimated H-index: 38
(SISSA: International School for Advanced Studies)
Prion diseases are fatal neurodegenerative disorders characterized by the cellular prion protein (PrPC) conversion into a misfolded and infectious isoform termed prion or PrPSc. The neuropathological mechanism underlying prion toxicity is still unclear, and the debate on prion protein gain- or loss-of-function is still open. PrPC participates to a plethora of physiological mechanisms. For instance, PrPC and copper cooperatively modulate N-methyl-D-aspartate receptor (NMDAR) activity by mediating...
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Published on Feb 1, 2019in Current Opinion in Pharmacology 5.20
Gianluigi Forloni58
Estimated H-index: 58
,
Ignazio Roiter4
Estimated H-index: 4
,
Fabrizio Tagliavini60
Estimated H-index: 60
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