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Publications 680
#1Erwei Zuo (CAS: Chinese Academy of Sciences)H-Index: 6
#2Yidi Sun (CAS: Chinese Academy of Sciences)H-Index: 8
Last. LIYixueH-Index: 57
view all 11 authors...
Cytosine base editors (CBEs) offer a powerful tool for correcting point mutations, yet their DNA and RNA off-target activities have caused concerns in biomedical applications. We describe screens of 23 rationally engineered CBE variants, which reveal mutation residues in the predicted DNA-binding site can dramatically decrease the Cas9-independent off-target effects. Furthermore, we obtained a CBE variant—YE1-BE3-FNLS—that retains high on-target editing efficiency while causing extremely low off...
#1Fangyoumin Feng (ShanghaiTech University)H-Index: 2
#2Zhengtao Zhang (CAS: Chinese Academy of Sciences)H-Index: 2
Last. Hong Li (CAS-MPG Partner Institute for Computational Biology)H-Index: 3
view all 6 authors...
Anti-cancer drug combination is an effective solution to improve treatment efficacy and overcome resistance. Here we propose a network-based method (DComboNet) to prioritize the candidate drug combinations. The level one model is to predict generalized anti-cancer drug combination effectiveness and level two model is to predict personalized drug combinations. By integrating drugs, genes, pathways and their associations, DComboNet achieves better performance than previous methods, with high AUC v...
#1Andrea Z. LaCroix (UdeM: Université de Montréal)H-Index: 102
#2Marcello D. Bronstein (USP: University of São Paulo)H-Index: 31
Last. C.-E. Ortmann (Novartis)
view all 13 authors...
PURPOSE: Cushing's disease (CD) is associated with significant clinical burden, increased mortality risk, and impaired health-related quality of life (HRQoL). This analysis explored the effect of long-acting pasireotide on clinical signs of hypercortisolism and HRQoL in a large subset of patients with CD. METHODS: In this phase III study ( NCT01374906), 150 adults with CD and a mean urinary free cortisol (mUFC) level between 1.5 and 5.0 times the upper limit of normal (ULN) st...
#1Y J Li (Fudan University)
#1Li Yp (Fudan University)H-Index: 2
Last. Yingjie Zheng (Fudan University)H-Index: 2
view all 7 authors...
Due to the flaws inherited in synchronicity, statistical association and survivor bias on variables under measurement, a common 'consensus' has been reached on "cross-sectiional studies (CSS) can lead to failure on causal inference". In this paper, under both causal thinking and diagram, the real and measured cross-sections are clearly defined that these two concepts only exist theoretically. In real CSS research, the temporal orders of measured variables are all non-synchronic, equivalent to th...
#1Leilei Wu (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Qinfang Deng (Tongji University)H-Index: 1
Last. LIYixue (SJTU: Shanghai Jiao Tong University)H-Index: 57
view all 6 authors...
BACKGROUND: Hybrid capture-based next-generation sequencing of DNA has been widely applied in the detection of circulating tumor DNA (ctDNA). Various methods have been proposed for ctDNA detection, but low-allelic-fraction (AF) variants are still a great challenge. In addition, no panel-wide calling algorithm is available, which hiders the full usage of ctDNA based 'liquid biopsy'. Thus, we developed the VBCALAVD (Virtual Barcode-based Calling Algorithm for Low Allelic Variant Detection) in sili...
#1Yin Wang (PRC: China Medical University (PRC))
#2Tao Huang (CAS: Chinese Academy of Sciences)H-Index: 29
Last. Xianzheng Sha (PRC: China Medical University (PRC))
view all 4 authors...
BACKGROUND: Aging is a fundamental biological process, where key bio-markers interact with each other and synergistically regulate the aging process. Thus aging dysfunction will induce many disorders. Finding aging markers and re-constructing networks based on multi-omics data (i.e. methylation, transcriptional and so on) are informative to study the aging process. However, optimizing the model to predict aging have not been performed systemically, although it is critical to identify potential m...
#1Bo Hu (Fudan University)H-Index: 10
#2Hong Li (CAS-MPG Partner Institute for Computational Biology)H-Index: 3
Last. Yang Xin-Rong (Fudan University)H-Index: 21
view all 15 authors...
#1Chuanyin Li (CAS: Chinese Academy of Sciences)
#1Chuanyin Li (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Guang Ning (SJTU: Shanghai Jiao Tong University)H-Index: 49
view all 21 authors...
#1Bin Li (Fudan University)H-Index: 22
#2Haichuan Hu (Fudan University)H-Index: 22
Last. LIYixue (Fudan University)H-Index: 57
view all 24 authors...
BACKGROUND: The benefit and harm of three-field lymphadenectomy for oesophageal cancer are still unknown. The aim of this study was to compare overall survival and morbidity and mortality between three- and two-field lymphadenectomy in patients with oesophageal squamous cell carcinoma. METHODS: Between March 2013 and November 2016, patients with squamous cell carcinoma of the middle or distal oesophagus were assigned randomly to open oesophagectomy with three-field (cervical-thoracic-abdominal) ...
#1Erwei ZuoH-Index: 6
#2Yidi Sun (CAS: Chinese Academy of Sciences)H-Index: 8
Last. LIYixue (CAS: Chinese Academy of Sciences)H-Index: 57
view all 11 authors...
Base editors hold promise for correcting pathogenic mutations, while substantial single nucleotide variations (SNVs) on both DNA and RNA were generated by cytosine base editors (CBEs). Here we examined possibilities to reduce off-target effects by engineering cytosine deaminases. By screening 24 CBEs harboring various rAPOBEC1 (BE3) or human APOBEC3A (BE3-hA3A) mutations on the ssDNA or RNA binding domain, we found 8 CBE variations could maintain high on-target editing efficiency. Using Genome-w...
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