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Farah Jaber-Hijazi
University of Glasgow
Induced pluripotent stem cellPlanarianStem cellGeneticsBiology
7Publications
5H-index
204Citations
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Publications 7
Newest
#1Yuliana MihaylovaH-Index: 5
#2Prasad AbnaveH-Index: 7
Last. A. Aziz AboobakerH-Index: 24
view all 8 authors...
Currently, little is known about the evolution of epigenetic regulation in animal stem cells. Here we demonstrate, using the planarian stem cell system to investigate the role of the COMPASS family of MLL3/4 histone methyltransferases that their function as tumor suppressors in mammalian stem cells is conserved over a long evolutionary distance. To investigate the potential conservation of a genome-wide epigenetic regulatory program in animal stem cells, we assess the effects of Mll3/4 loss of f...
5 CitationsSource
#1John van Tuyn (Glas.: University of Glasgow)H-Index: 18
#2Farah Jaber-Hijazi (Glas.: University of Glasgow)H-Index: 5
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
view all 14 authors...
On acquisition of an oncogenic mutation, primary human and mouse cells can enter oncogene-induced senescence (OIS). OIS is characterized by a stable proliferation arrest and secretion of proinflammatory cytokines and chemokines, the senescence-associated secretory phenotype. Proliferation arrest and the senescence-associated secretory phenotype collaborate to enact tumor suppression, the former by blocking cell proliferation and the latter by recruiting immune cells to clear damaged cells. Howev...
7 CitationsSource
#1Yuliana Mihaylova (University of Oxford)H-Index: 5
#2Damian Kao (University of Oxford)H-Index: 8
Last. A. Aziz Aboobaker (University of Oxford)H-Index: 24
view all 8 authors...
Currently, little is known about the evolution of epigenetic regulation in animal stem cells. Using the planarian stem cell system to investigate the role of the COMPASS family of MLL3/4 histone methyltransferases, we demonstrate that their role as tumour suppressors in stem cells is conserved over a large evolutionary distance in animals. This also suggested the potential conservation of a genome wide epigenetic regulation program in animal stem cells, so we assessed the regulatory effects of M...
4 CitationsSource
#1David M. Nelson (Glas.: University of Glasgow)H-Index: 9
#2Farah Jaber-Hijazi (Glas.: University of Glasgow)H-Index: 5
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
view all 23 authors...
Background Histone modification H4K20me3 and its methyltransferase SUV420H2 have been implicated in suppression of tumorigenesis. The underlying mechanism is unclear, although H4K20me3 abundance increases during cellular senescence, a stable proliferation arrest and tumor suppressor process, triggered by diverse molecular cues, including activated oncogenes. Here, we investigate the function of H4K20me3 in senescence and tumor suppression.
12 CitationsSource
#1Farah Jaber-Hijazi (University of Oxford)H-Index: 5
#2Priscilla J.K.P. Lo (University of Nottingham)H-Index: 1
Last. A. Aziz Aboobaker (University of Oxford)H-Index: 24
view all 11 authors...
Planarian adult stem cells (pASCs) or neoblasts represent an ideal system to study the evolution of stem cells and pluripotency as they underpin an unrivaled capacity for regeneration. We wish to understand the control of differentiation and pluripotency in pASCs and to understand how conserved, convergent or divergent these mechanisms are across the Bilateria. Here we show the planarian methyl-CpG Binding Domain 2/3 (mbd2/3) gene is required for pASC differentiation during regeneration and tiss...
22 CitationsSource
#1Jordi Solana (University of Nottingham)H-Index: 12
#2Damian Kao (University of Nottingham)H-Index: 8
Last. A. Aziz Aboobaker (University of Nottingham)H-Index: 24
view all 7 authors...
Background Planarian stem cells, or neoblasts, drive the almost unlimited regeneration capacities of freshwater planarians. Neoblasts are traditionally described by their morphological features and by the fact that they are the only proliferative cell type in asexual planarians. Therefore, they can be specifically eliminated by irradiation. Irradiation, however, is likely to induce transcriptome-wide changes in gene expression that are not associated with neoblast ablation. This has affected the...
96 CitationsSource
#1Thomas C.J. Tan (University of Nottingham)H-Index: 1
#2Ruman Rahman (University of Nottingham)H-Index: 11
Last. A. Aziz Aboobaker (University of Oxford)H-Index: 24
view all 7 authors...
In most sexually reproducing animals, replication and maintenance of telomeres occurs in the germ line and during early development in embryogenesis through the use of telomerase. Somatic cells generally do not maintain telomere sequences, and these cells become senescent in adults as telomeres shorten to a critical length. Some animals reproduce clonally and must therefore require adult somatic mechanisms for maintaining their chromosome ends. Here we study the telomere biology of planarian fla...
58 CitationsSource
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