Dianna M. Milewicz
University of Texas Health Science Center at Houston
CardiologyAortic dissectionMarfan syndromeMedicineBiology
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Publications 334
#1Sarah J. ParkerH-Index: 12
#2Amanda OroscoH-Index: 1
Last. Ali AzizzadehH-Index: 29
view all 5 authors...
#1Enrique AudainH-Index: 6
#2Anna Wilsdon (University of Nottingham)H-Index: 2
view all 51 authors...
Congenital Heart Disease (CHD) affects approximately 7-9 children per 1000 live births. Numerous genetic studies have established a role for rare genomic variants at the copy number variation (CNV) and single nucleotide variant level. In particular, the role of de novo mutations (DNM) has been highlighted in syndromic and non-syndromic CHD. To identify novel haploinsufficient CHD disease genes we performed an integrative analysis of CNVs and DNMs identified in probands with CHD including cases w...
#1Alexander P. Nissen (University of Texas Health Science Center at Houston)H-Index: 3
#2Van Thi Thanh Truong (University of Texas Health Science Center at Houston)H-Index: 6
Last. Barbara L. KronerH-Index: 24
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Abstract Objective Bicuspid aortic valve (BAV) is a common risk factor for thoracic aortic aneurysm and dissection. Guidelines for elective ascending aortic intervention (AAI) in BAV are derived from limited evidence, and the extent of practice variation due to patient and provider characteristics is unknown. Using data from two large cardiovascular registries (BAVCon and GenTAC), we investigated factors that influence decisions for AAI. Methods All BAV cases with known aortic diameters and surg...
3 CitationsSource
#1Katia Bravo-Jaimes (University of Texas Health Science Center at Houston)H-Index: 1
#2Naddi B. Marah (University of Texas Health Science Center at Houston)
Last. Siddharth K. Prakash (University of Texas Health Science Center at Houston)H-Index: 24
view all 9 authors...
#1Jian Gong (UM: University of Michigan)H-Index: 1
#2Dong Zhou (UM: University of Michigan)
Last. Bo Yang (UM: University of Michigan)H-Index: 11
view all 7 authors...
Objective: SMAD3 pathogenic variants are associated with the development of thoracic aortic aneurysms. We sought to determine the role of SMAD3 in lineage-specific vascular smooth muscle cells (VSM...
#1William C. Frankel (BCM: Baylor College of Medicine)H-Index: 3
#2Howard K. Song (OHSU: Oregon Health & Science University)H-Index: 25
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Abstract Background Although patients with various types of heritable aortopathy often require distal aortic repair, data are limited regarding the most extensive operations—open thoracoabdominal aortic aneurysm (TAAA) repairs. The objective of this multicenter registry study was to characterize TAAA repairs in a large cohort of patients with different heritable aortic diseases. Methods From the 3,699 patients enrolled at 8 participating centers in the Genetically Triggered Thoracic Aortic Aneur...
1 CitationsSource
#1Pingping Ren (The Texas Heart Institute)H-Index: 7
#2Darrell Wu (The Texas Heart Institute)H-Index: 7
Last. Dianna M. Milewicz (University of Texas Health Science Center at Houston)H-Index: 62
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Background Aortic aneurysms and dissections are highly lethal diseases for which an effective treatment strategy is critically needed to prevent disease progression. The nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 (NLRP3)-caspase-1 inflammasome cascade was recently shown to play an important role in aortic destruction and disease development. In this study, we tested the effects of MCC950, a potent, selective NLRP3 inhibitor, on preventing aortic destruction...
#1Amélie PinardH-Index: 3
Last. Chaker AlouiH-Index: 8
view all 14 authors...
Introduction: Moyamoya disease (MMD) is a cerebrovascular disease often causing pediatric onset strokes and characterized by progressive bilateral occlusion of the distal internal carotid arteries ...
#1Sherene Shalhub (UW: University of Washington)H-Index: 14
#2Mary J. Roman (Cornell University)H-Index: 93
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Abstract Background To investigate clinical course of patients with TBAD occurring at a young age with confirmed or suspected heritable thoracic aortic disease Methods Individuals with TBAD occurring at an age Results A total of 150 individuals met inclusion criteria (mean age of TBAD 36.9+9 years): 73 MFS TBAD, 42 FTBAD, and 35 sporadic TBAD. The cohort of sporadic TBAD had more males (71.4%) and less individuals of European descent (51.4%) compared to MFS TBAD (57.5% male, 84.9% European desce...
1 CitationsSource