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Dianna M. Milewicz
University of Texas Health Science Center at Houston
318Publications
56H-index
12.4kCitations
Publications 318
Newest
Published in Nature Communications 11.88
Gerburg K. Schwaerzer2
Estimated H-index: 2
(UCSD: University of California, San Diego),
Hema Kalyanaraman5
Estimated H-index: 5
(UCSD: University of California, San Diego)
+ -3 AuthorsHemal H. Patel41
Estimated H-index: 41
(UCSD: University of California, San Diego)
People heterozygous for an activating mutation in protein kinase G1 (PRKG1, p.Arg177Gln) develop thoracic aortic aneurysms and dissections (TAAD) as young adults. Here we report that mice heterozygous for the mutation have a three-fold increase in basal protein kinase G (PKG) activity, and develop age-dependent aortic dilation. Prkg1R177Q/+ aortas show increased smooth muscle cell apoptosis, elastin fiber breaks, and oxidative stress compared to aortas from wild type littermates. Transverse aort...
Published on Mar 1, 2019in Journal of Vascular Surgery 3.24
Sherene Shalhub13
Estimated H-index: 13
(UW: University of Washington),
Ellen S. Regalado24
Estimated H-index: 24
(University of Texas Health Science Center at Houston)
+ 1 AuthorsDianna M. Milewicz56
Estimated H-index: 56
(University of Texas Health Science Center at Houston)
Abstract Objective The c.530G>A (p.Arg177Gln) mutation in PRKG1 has been shown to be associated with thoracic aortic aneurysms and dissections. This rare mutation accounts for an estimated 1% of nonsyndromic heritable thoracic aortic disease. We sought to describe the clinical presentation of type B aortic dissection (TBAD), management, and outcomes in patients with this mutation. Methods This is a descriptive multi-institutional retrospective study of patients from six families with the PRKG1 m...
Published in The Annals of Thoracic Surgery 3.92
Sherene Shalhub13
Estimated H-index: 13
(UW: University of Washington),
Mary J. Roman90
Estimated H-index: 90
(Cornell University)
+ -3 AuthorsDianna M. Milewicz56
Estimated H-index: 56
(University of Texas Health Science Center at Houston)
Abstract Background To investigate clinical course of patients with TBAD occurring at a young age with confirmed or suspected heritable thoracic aortic disease Methods Individuals with TBAD occurring at an age Results A total of 150 individuals met inclusion criteria (mean age of TBAD 36.9+9 years): 73 MFS TBAD, 42 FTBAD, and 35 sporadic TBAD. The cohort of sporadic TBAD had more males (71.4%) and less individuals of European descent (51.4%) compared to MFS TBAD (57.5% male, 84.9% European desce...
Published in Journal of Vascular Surgery 3.24
Sherene Shalhub13
Estimated H-index: 13
(UW: University of Washington),
Peter H. Byers69
Estimated H-index: 69
(UW: University of Washington)
+ -3 AuthorsKatie E. Shean7
Estimated H-index: 7
(BIDMC: Beth Israel Deaconess Medical Center)
Abstract Objective Vascular Ehlers-Danlos syndrome (vEDS) is a rare disorder and 1 of 13 types of EDS. The syndrome results in aortic and arterial aneurysms and dissections at a young age. Diagnosis is confirmed with molecular testing via skin biopsy or genetic testing for COL3A1 pathogenic variants. We describe a multi-institutional experience in the diagnosis of vEDS from 2000 to 2015. Methods This is a multi-institutional cross-sectional retrospective study of individuals with vEDS. The insti...
Published on Feb 26, 2019in European Journal of Human Genetics 3.65
Xue-Yan Duan1
Estimated H-index: 1
(University of Texas Health Science Center at Houston),
Dongchuan Guo32
Estimated H-index: 32
(University of Texas Health Science Center at Houston)
+ 9 AuthorsDeborah A. Nickerson90
Estimated H-index: 90
(UW: University of Washington)
SMAD4 pathogenic variants cause juvenile polyposis (JPS) and hereditary hemorrhagic telangiectasia (HHT), and 40% of affected individuals also have thoracic aortic disease. At the same time, SMAD4 pathogenic variants have not been reported in thoracic aortic disease families without JPS-HHT. A SMAD4 heterozygous variant, c.290G>T, p.(Arg97Leu), not present in population databases and predicted to be damaging to protein function, was identified in a family with thoracic aortic disease and no evid...
Published on May 8, 2019in JAMA Cardiology
Marion A. Hofmann Bowman1
Estimated H-index: 1
(UM: University of Michigan),
Kim A. Eagle114
Estimated H-index: 114
(UM: University of Michigan),
Dianna M. Milewicz56
Estimated H-index: 56
(University of Texas Health Science Center at Houston)
Importance Thoracic aortic aneurysms leading to acute aortic dissections are a major cause of morbidity and mortality despite significant advances in surgical treatment, which remains the main intervention to prevent type A dissections. In the past 2 decades progress had been made toward a better understanding of molecular mechanisms that lead to aneurysm formation and dissections of the thoracic aorta. This focused review emphasizes the results of clinical trials using β-blocker, losartan potas...
Published on Jun 1, 2019
Brooke N. Wolford4
Estimated H-index: 4
(UM: University of Michigan),
Whitney Hornsby6
Estimated H-index: 6
(UM: University of Michigan)
+ 21 AuthorsEllen M. Schmidt16
Estimated H-index: 16
Background: Thoracic aortic dissection is an emergent life-threatening condition. Routine screening for genetic variants causing thoracic aortic dissection is not currently performed for patients o...
Published on Feb 27, 2019in The FASEB Journal 5.39
Ziqing Wang7
Estimated H-index: 7
(University of Texas Health Science Center at Houston),
Ming Cai3
Estimated H-index: 3
(HUST: Huazhong University of Science and Technology)
+ 8 AuthorsDianna M. Milewicz56
Estimated H-index: 56
(University of Texas Health Science Center at Houston)
Very little is known about how lipid signaling regulates intima hyperplasia after vascular injury. Herein, we report that deletion and pharmacological inhibition of phospholipase D (PLD)2, which generates the signaling lipid phosphatidic acid (PA), reduced neointimal formation in the mouse carotid artery ligation model. PLD2 deficiency inhibits migration of vascular smooth muscle cells (VSMCs) into the intima in mice as well as migration and formation of membrane ruffles in primary VSMCs. PA spe...
Published on May 1, 2019in American Journal of Medical Genetics Part A 2.20
Sherene Shalhub13
Estimated H-index: 13
(UW: University of Washington),
Enid Neptune16
Estimated H-index: 16
(Johns Hopkins University)
+ 4 AuthorsDianna M. Milewicz56
Estimated H-index: 56
(University of Texas Health Science Center at Houston)
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