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Holly E. Ponichtera
Tufts University
6Publications
4H-index
63Citations
Publications 6
Newest
#1Parisa Kalantari (Tufts University)H-Index: 1
#2Yoelkys Morales (Tufts University)H-Index: 1
Last.Miguel J. Stadecker (Tufts University)H-Index: 39
view all 11 authors...
Summary The immunopathology caused by schistosome helminths varies greatly in humans and among mouse strains. A severe form of parasite egg-induced hepatic granulomatous inflammation, seen in CBA mice, is driven by Th17 cells stimulated by IL-1β and IL-23 produced by dendritic cells that express CD209a (SIGNR5), a C-type lectin receptor (CLR) related to human DC-SIGN. Here, we show that CD209a-deficient CBA mice display decreased Th17 responses and are protected from severe immunopathology. In v...
5 CitationsSource
#1Holly E. Ponichtera (Tufts University)H-Index: 4
#2Miguel J. Stadecker (Tufts University)H-Index: 39
Abstract Following infection with the trematode helminth Schistosoma mansoni , CBA mice develop severe parasite egg-induced hepatic granulomatous inflammation as well as prominent CD4 + T helper 17 (Th17) cell responses driven by dendritic cell (DC)-derived IL-1β and IL-23. By comparison, C57BL/6 mice develop mild hepatic immunopathology, egg stimulation of DCs does not result in IL-1β and IL-23 production, and Th17 cells fail to develop. To investigate the reasons for strain-specific difference...
6 CitationsSource
#1Holly E. Ponichtera (Tufts University)H-Index: 4
#2Mara G. Shainheit (Tufts University)H-Index: 11
Last.Miguel J. Stadecker (Tufts University)H-Index: 39
view all 14 authors...
In murine schistosomiasis, immunopathology and cytokine production in response to parasite eggs are uneven and strain dependent. CBA/J (CBA) mice develop severe hepatic granulomatous inflammation associated with prominent Th17 cell responses driven by dendritic cell (DC)-derived IL-1β and IL-23. Such Th17 cells fail to develop in low-pathology C57BL/6 (BL/6) mice, and the reasons for these strain-specific differences in APC reactivity to eggs remain unclear. We show by gene profiling that CBA DC...
18 CitationsSource
#1Holly E. Ponichtera (Tufts University)H-Index: 4
#2Mara G. Shainheit (Tufts University)H-Index: 11
Last.Miguel J. Stadecker (Tufts University)H-Index: 39
view all 14 authors...
The magnitude of immunopathology and pro-inflammatory cytokine production in murine Schistosoma mansoni infection is strain-dependent. Severe hepatic egg-induced granulomatous inflammation in CBA mice is associated with Th1 and Th17 cytokine responses, whereas BL/6 mice develop milder lesions in a Th2-polarized cytokine environment. Pathogenic Th17 cell responses in CBA mice are dependent on the production of IL-1β and IL-23 by egg-stimulated dendritic cells (DC); by comparison, such Th17 cells ...
#1Bridget Larkin (Tufts University)H-Index: 5
#2Patrick M. Smith (Tufts University)H-Index: 7
Last.Miguel J. Stadecker (Tufts University)H-Index: 39
view all 6 authors...
Schistosomiasis is a major tropical disease caused by trematode helminths in which the host mounts a pathogenic immune response against tissue-trapped parasite eggs. The immunopathology consists of egg antigen-specific CD4 T cell-mediated granulomatous inflammation that varies greatly in magnitude in humans and among mouse strains in an experimental model. New evidence, covered in this review, intimately ties the development of severe pathology to IL-17-producing CD4 T helper (Th17) cells, a fin...
34 CitationsSource
#2Mara G. ShainheitH-Index: 11
Last.Miguel J. StadeckerH-Index: 39
view all 4 authors...
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