Match!
Timothy Buie
Harvard University
37Publications
17H-index
1,850Citations
Publications 37
Newest
#1Kara Gross Margolis (Morgan Stanley Children's Hospital)H-Index: 15
#2Timothy Buie (Harvard University)H-Index: 17
Last.Jeremy Veenstra-VanderWeele (CUMC: Columbia University Medical Center)H-Index: 38
view all 10 authors...
Gastrointestinal dysfunction in children with autism spectrum disorder (ASD) is common and associated with problem behaviors. This study describes the development of a brief, parent-report screen that relies minimally upon the child’s ability to report or localize pain for identifying children with ASD at risk for one of three common gastrointestinal disorders (functional constipation, functional diarrhea, and gastroesophageal reflux disease). In a clinical sample of children with ASD, this 17-i...
#1Shannon RoseH-Index: 14
#2Sirish C. BennuriH-Index: 7
Last.Richard E. FryeH-Index: 4
view all 6 authors...
Gastrointestinal (GI) symptoms are prevalent in autism spectrum disorder (ASD) but the pathophysiology is poorly understood. Imbalances in the enteric microbiome have been associated with ASD and can cause GI dysfunction potentially through disruption of mitochondrial function as microbiome metabolites modulate mitochondrial function and mitochondrial dysfunction is highly associated with GI symptoms. In this study, we compared mitochondrial function in rectal and cecum biopsies under the assump...
There is evidence that symptoms of maldigestion or malabsorption in autistic individuals are related to changes in the indigenous microbiota. Analysis of colonic bacteria has revealed microbial dysbiosis in children with autism; however, characteristics of the duodenal microbiome are not well described. In the present study the microbiome of the duodenal mucosa of subjects with autism was evaluated for dysbiosis, bacteria overgrowth, and microbiota associated with carbohydrate digestion. The rel...
#1Maria Fiorentino (Harvard University)H-Index: 13
#2Anna Sapone (Harvard University)H-Index: 19
Last.Nicola G. CascellaH-Index: 29
view all 8 authors...
Background Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene–environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood–brain barrier (BBB), can be par...
ABSTRACTObjective:Alterations in intestinal function, often characterized as a “leaky gut,” have been attributed to children who are on the autism spectrum. Disaccharidase activity, intestinal inflammation, and permeability were analyzed in 61 children with autism and 50 nonautistic individuals with
#1Lonnie Zwaigenbaum (U of A: University of Alberta)H-Index: 63
#2Margaret L. Bauman (BU: Boston University)H-Index: 16
Last.Robin L. Hansen (UC Davis: University of California, Davis)H-Index: 36
view all 10 authors...
* Abbreviations: ASD — : autism spectrum disorder DSM-5 — : Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition M-CHAT — : Modified Checklist for Autism in Toddlers Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by impaired social communication skills and isolated areas of interest.1 The current prevalence of these disorders is estimated to be 1 in 68,2 and recent estimates of the risk of recurrence in families with at least 1 child diagnosed wit...
#1Lonnie Zwaigenbaum (U of A: University of Alberta)H-Index: 63
#2Margaret L. Bauman (BU: Boston University)H-Index: 16
Last.Roula Choueiri (UMMS: University of Massachusetts Medical School)H-Index: 9
view all 10 authors...
This article reviews current evidence for autism spectrum disorder (ASD) screening based on peer-reviewed articles published to December 2013. Screening provides a standardized process to ensure that children are systematically monitored for early signs of ASD to promote earlier diagnosis. The current review indicates that screening in children aged 18 to 24 months can assist in early detection, consistent with current American Academy of Pediatrics’ recommendations. We identify ASD-specific and...
#1Lonnie Zwaigenbaum (U of A: University of Alberta)H-Index: 63
#2Margaret L. Bauman (BU: Boston University)H-Index: 16
Last.Deborah Fein (UConn: University of Connecticut)H-Index: 48
view all 10 authors...
This article reviews current evidence for autism spectrum disorder (ASD) interventions for children aged
1234