Timothy Buie
Harvard University
EndocrinologyAutismAutism spectrum disorderDiabetes mellitusMedicine
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Publications 40
#1Kara Gross MargolisH-Index: 15
#2Timothy BuieH-Index: 19
Last. Harland S. WinterH-Index: 46
view all 12 authors...
#1Kara Gross Margolis (Morgan Stanley Children's Hospital)H-Index: 15
#2Timothy Buie (Harvard University)H-Index: 19
Last. Harland S. Winter (Harvard University)H-Index: 46
view all 12 authors...
Gastrointestinal dysfunction in children with autism spectrum disorder (ASD) is common and associated with problem behaviors. This study describes the development of a brief, parent-report screen that relies minimally upon the child’s ability to report or localize pain for identifying children with ASD at risk for one of three common gastrointestinal disorders (functional constipation, functional diarrhea, and gastroesophageal reflux disease). In a clinical sample of children with ASD, this 17-i...
4 CitationsSource
#1Elisa C. Walsh (MIT: Massachusetts Institute of Technology)H-Index: 3
#2Johanna M. Lee (MIT: Massachusetts Institute of Technology)H-Index: 4
Last. Patrick L. Purdon (Harvard University)H-Index: 33
view all 11 authors...
Patients with autism spectrum disorder (ASD) often require sedation or general anesthesia. ASD is thought to arise from deficits in GABAergic signaling leading to abnormal neurodevelopment. We sought to investigate differences in how ASD patients respond to the GABAergic drug propofol by comparing the propofol-induced electroencephalogram (EEG) of ASD and neurotypical (NT) patients. This investigation was a prospective observational study. Continuous 4-channel frontal EEG was recorded during rou...
1 CitationsSource
#1Elisa C. WalshH-Index: 3
#2Johanna M. LeeH-Index: 4
Last. Patrick L. PurdonH-Index: 33
view all 11 authors...
#1Shannon RoseH-Index: 15
#2Sirish C. BennuriH-Index: 9
Last. Richard E. FryeH-Index: 37
view all 6 authors...
Gastrointestinal (GI) symptoms are prevalent in autism spectrum disorder (ASD) but the pathophysiology is poorly understood. Imbalances in the enteric microbiome have been associated with ASD and can cause GI dysfunction potentially through disruption of mitochondrial function as microbiome metabolites modulate mitochondrial function and mitochondrial dysfunction is highly associated with GI symptoms. In this study, we compared mitochondrial function in rectal and cecum biopsies under the assump...
10 CitationsSource
There is evidence that symptoms of maldigestion or malabsorption in autistic individuals are related to changes in the indigenous microbiota. Analysis of colonic bacteria has revealed microbial dysbiosis in children with autism; however, characteristics of the duodenal microbiome are not well described. In the present study the microbiome of the duodenal mucosa of subjects with autism was evaluated for dysbiosis, bacteria overgrowth, and microbiota associated with carbohydrate digestion. The rel...
13 CitationsSource
#1Maria Fiorentino (Harvard University)H-Index: 13
#2Anna Sapone (Harvard University)H-Index: 20
Last. Nicola G. CascellaH-Index: 29
view all 9 authors...
Background Autism spectrum disorders (ASD) are complex conditions whose pathogenesis may be attributed to gene–environment interactions. There are no definitive mechanisms explaining how environmental triggers can lead to ASD although the involvement of inflammation and immunity has been suggested. Inappropriate antigen trafficking through an impaired intestinal barrier, followed by passage of these antigens or immune-activated complexes through a permissive blood–brain barrier (BBB), can be par...
65 CitationsSource
ABSTRACTObjective:Alterations in intestinal function, often characterized as a “leaky gut,” have been attributed to children who are on the autism spectrum. Disaccharidase activity, intestinal inflammation, and permeability were analyzed in 61 children with autism and 50 nonautistic individuals with
19 CitationsSource
#1W. Allan WalkerH-Index: 60
Last. Timothy BuieH-Index: 19
view all 7 authors...
#1Lonnie Zwaigenbaum (U of A: University of Alberta)H-Index: 67
#2Margaret L. Bauman (BU: Boston University)H-Index: 17
Last. Marvin R. Natowicz (Cleveland Clinic)H-Index: 33
view all 22 authors...
This article reviews current evidence for autism spectrum disorder (ASD) interventions for children aged
129 CitationsSource