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Hossein Baharvand
University of Science and Culture
Embryonic stem cellMolecular biologyStem cellBiologyCell biology
482Publications
44H-index
7,529Citations
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Publications 529
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#1Adeleh Taei (University of Science and Culture)H-Index: 13
#2Azam Samadian (Royan Institute)H-Index: 3
Last. Yaser Tahamtani (University of Science and Culture)H-Index: 6
view all 12 authors...
Abstract The ability of human embryonic stem cells (hESCs) to proliferate unlimitedly and give rise to all tissues makes these cells a promising source for cell replacement therapies. To realize the full potential of hESCs in cell therapy, it is necessary to interrogate regulatory pathways that influence hESC maintenance and commitment. Here, we reveal that pharmacological attenuation of p38 mitogen-activated protein kinase (p38-MAPK) in hESCs concomitantly augments some characteristics associat...
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#1Heidar Heidari-Khoei (Royan Institute)
#2Fereshteh Esfandiari (Royan Institute)H-Index: 3
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 6 authors...
Recent developments in organoid technology are revolutionizing our knowledge about the biology, physiology, and function of various organs. Female reproductive biology and medicine also benefit from this technology. Organoids recapitulate features of different reproductive organs including the uterus, fallopian tubes, and ovaries, as well as trophoblasts. The genetic stability of organoids and long-lasting commitment to their tissue of origin during long-term culture makes them attractive substi...
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#1Fahimeh Hosseini (TMU: Tarbiat Modares University)H-Index: 2
#2Bahram Mohammad Soltani (TMU: Tarbiat Modares University)H-Index: 10
Last. Saman Hosseinkhani (TMU: Tarbiat Modares University)H-Index: 28
view all 4 authors...
The pluripotency factor, OCT4 gene is a stemness marker that is involved in the tumorigenicity of different cancer types, and knowing about molecular mechanisms of its regulation is crucially important. To date, a few microRNAs (miRNAs) are known to be regulators of OCT4 gene expression. Looking for the novel miRNAs which are capable of regulating OCT4 gene expression, our bioinformatics analysis introduced hsa-miR-3658 (miR-3658) as a bona fide candidate. Then, RT-qPCR results indicated that mi...
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#1Saghar Pahlavanneshan (TMU: Tarbiat Modares University)H-Index: 1
#2Mehrdad Behmanesh (TMU: Tarbiat Modares University)H-Index: 19
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 8 authors...
Abstract Both type 1 and type 2 diabetes are associated with hyperglycemia and loss of functional beta cell mass. Inducing proliferation of preexisting beta cells is an approach to increase the numbers of beta cells. In this study, we examined a panel of selected small molecules for their proliferation-inducing effects on human pancreatic beta cells. Our results demonstrated that a small molecule inhibitor of the menin-MLL interaction (MI-2) and small molecule inhibitors of TGF-β signaling (SB43...
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#1Seyedeh-Zahra Seyedrazizadeh (Royan Institute)
#2Sara Poosti (Royan Institute)
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 9 authors...
Retinal and/or optic nerve injury is one of the leading causes of blindness due to retinal ganglion cell (RGC) degeneration. There have been extensive efforts to suppress this neurodegeneration. Various somatic tissue-derived mesenchymal stem cells (MSCs) demonstrated significant neuroprotective and axogenic effects on RGCs. An alternative source of MSCs could be human embryonic stem cells (ES-MSCs), which proliferate faster, express lower levels of inflammatory cytokines, and are capable of imm...
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#1Mohammad-Hossein Haddadi (Tehran University of Medical Sciences)
#2Babak Negahdari (Tehran University of Medical Sciences)H-Index: 10
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 7 authors...
: Regulatory T (Treg) cell therapy is a promising approach for immune tolerance induction in autoimmunity conditions and cell/organ transplantations. Insufficient isolation yields and impurity during downstream processes and Treg instability after adoptive transfer in inflammatory conditions are major limitations to Treg therapy, and indicate the importance of seeking a valid, reliable method for de novo generation of Tregs. In this research, we evaluated Treg-like cells obtained from different ...
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#1Zahra NazemiH-Index: 1
#2M. S. NourbakhshH-Index: 7
Last. Hossein BaharvandH-Index: 44
view all 7 authors...
Abstract Spinal cord injury (SCI) induces pathological and inflammatory responses that create an inhibitory environment at the site of trauma, resulting in axonal degeneration and functional disability. Combination therapies targeting multiple aspects of the injury, will likely be more effective than single therapies to facilitate tissue regeneration after SCI. In this study, we designed a dual-delivery system consisting of a neuroprotective drug, minocycline hydrochloride (MH), and a neuroregen...
1 CitationsSource
#1M. IzadiH-Index: 1
view all 15 authors...
Background & Aim Background Insulin injection is a routine treatment for type-1 diabetes which couldn't result in physiologic reaction to blood glucose changes and patients are encountered with diabetes complications. Therefore, a treatment option that leads to modulate the immune system and mitigate the procedure of insulitis could be a hopeful clinical choice. Mesenchymal Stem Cells (MSC) have been shown to have immunomodulatory and regenerative effects. Aim In this clinical trial, autologous ...
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#1Mohammad-Hossein Haddadi (Tehran University of Medical Sciences)
#2Ensiyeh Hajizadeh-Saffar (Royan Institute)H-Index: 5
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 6 authors...
Abstract Chimeric immune receptors (CIRs) are functionally pleiotropic because they are artificially expressed on diverse cell types, which gives specificity to their function to anergize, kill, or protect cognate target cells. CIRs consist of chimeric antigen receptors (CARs) and B-cell antibody receptor (BAR) or chimeric autoantibody receptors (CAARs). Approval of CAR-T cell therapy by the Food and Drug Administration (FDA) has encouraged investigators to search for autoimmune therapies that a...
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#2Shideh AssarH-Index: 3
Last. Hossein Baharvand (Royan Institute)H-Index: 44
view all 6 authors...
Background & Aim Somatic cell therapy medicinal products is the largest group of advanced therapy medicinal products used in clinical trials which also resulted in routinely production of huge amount of conditioned medium. With its capacity to be used as therapeutics agents, cell-conditioned medium derived extracellular vesicles (EVs) play an explosive role in the realm of regenerative medicine or pharmaceutical science. However, the heterogeneity of EVs usually resolved by isolation of differen...
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