Hossein Baharvand
University of Science and Culture
Embryonic stem cellMolecular biologyStem cellBiologyCell biology
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Publications 515
#1Zahra NazemiH-Index: 1
#2M. S. NourbakhshH-Index: 7
Last. Hossein BaharvandH-Index: 44
view all 7 authors...
Abstract Spinal cord injury (SCI) induces pathological and inflammatory responses that create an inhibitory environment at the site of trauma, resulting in axonal degeneration and functional disability. Combination therapies targeting multiple aspects of the injury, will likely be more effective than single therapies to facilitate tissue regeneration after SCI. In this study, we designed a dual-delivery system consisting of a neuroprotective drug, minocycline hydrochloride (MH), and a neuroregen...
#1Adeleh Taei (University of Science and Culture)H-Index: 13
#2Paniz Rasooli (Royan Institute)
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 5 authors...
Abstract Pluripotent cells transiently develop during peri-implantation embryogenesis and have the capacity to convert into three embryonic lineages. Two typical states of pluripotency, naive and primed, can be experimentally induced in vitro. The in vitro naive state can be stabilized in response to environmental inductive cues via a unique transcriptional regulatory program. However, interference with various signaling pathways creates a spectrum of alternative pluripotent cells that display d...
#1Amir BajouriH-Index: 2
#2Zahra OroujiH-Index: 2
Last. N. AghdamiH-Index: 6
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Objective: Recently, the promising potential of fibroblast transplantation has become a novel modality for skin rejuvenation. We investigated the long-term safety and efficacy of autologous fibroblast transplantation for participants with mild to severe facial contour deformities. Materials and Methods: In this open-label, single-arm phase IIa clinical trial, a total of 57 participants with wrinkles (n=37, 132 treatment sites) or acne scars (n=20, 36 treatment sites) who had an evaluator's asses...
#1Melika Parchehbaf-Kashani (Shahid Beheshti University)H-Index: 1
#2Mohammadmajid Sepantafar (Royan Institute)H-Index: 5
Last. Sarah Rajabi (Royan Institute)H-Index: 4
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Abstract Cardiovascular diseases (CVD) are a major cause of mortality worldwide. Accessibility to heart tissue is limited due to sampling issues and lack of appropriate culture conditions. In addition, animal models are not an ideal choice for physiological, pharmacological, and fundamental evaluations in the cardiovascular field due to interspecies differences. Hence, there is an inevitable need for functional in vitro cardiac models. In this study, we have synthesized a novel electroconductive...
1 CitationsSource
#2Mojgan ZandiH-Index: 15
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
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#1Zahra Nazemi (Semnan University)H-Index: 1
#2M. S. Nourbakhsh (Semnan University)H-Index: 7
Last. Hossein Baharvand (University of Science and Culture)H-Index: 44
view all 6 authors...
Abstract The ionic complexation of different chemical compositions of alginate and its sulfated derivative with tetracycline hydrochloride (TCH), as a cationic drug model, was investigated. The complexes of TCH with mannuronate-enriched alginate entrapped the highest amount of the drug. However, the ability of all un-modified alginates for ionic complexation was very weak. Interestingly, the chemical modification of alginate with sulfate groups resulted in drug-polymer complexes with remarkable ...
#1Fatemeh Nobakht Lahrood (Royan Institute)
#1Fatemeh Nobakht (Royan Institute)
Last. Abbas Piryaei (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 14
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Abstract Cell therapy and tissue engineering (TE) are considered as alternatives therapeutic approaches to organ transplantation. Since cell therapy approaches achieved little success for liver fai...
#1Masoumeh Zarei‐Kheirabadi (Royan Institute)
#2Alexander R. Vaccaro (Thomas Jefferson University)H-Index: 80
Last. Hossein Baharvand (Royan Institute)H-Index: 44
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Over the past few decades, our knowledge about the function of the central nervous system (CNS) and astrocytes has improved, and research has confirmed the key roles that astrocytes play in the phy...
Abstract Oligodendrocyte precursor cells (OPCs) are ideal therapeutic cells for treatment of spinal cord injuries and diseases that affect myelin. However, it is necessary to generate a cell population with a low risk of teratoma formation and oncogenesis from a patient’s somatic cells. In this study, we investigated the direct reprogramming of fibroblasts to oligodendrocyte-like cells in one step with a safe non-genetic delivery method that used protein transduction. Cell morphology and the lin...
#1Saman Firoozi (IUMS: Iran University of Medical Sciences)H-Index: 1
#2Sara Pahlavan (Royan Institute)H-Index: 6
Last. Fariba Moslem (Royan Institute)
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Abstract Purpose The aim of this study was to investigate the cardiac repair effect of human bone marrow mesenchymal stromal cells-derived extracellular vesicles (MSC-EVs) after intramyocardial injection in free form or encapsulated within a self-assembling peptide hydrogel modified with SDKP motif, in a rat model of myocardial infarction (MI). Methods MSC-EVs were isolated by ultracentrifuge and characterized for physical parameters and surface proteins. Furthermore, cellular uptake and cardiop...