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Hossein Baharvand
Royan Institute
Publications 392
Published on Dec 1, 2019in Stem Cell Research & Therapy 4.63
Maryam Kay4
Estimated H-index: 4
(TMU: Tarbiat Modares University),
Bahram Mohammad Soltani9
Estimated H-index: 9
(TMU: Tarbiat Modares University)
+ 2 AuthorsHossein Baharvand42
Estimated H-index: 42
(University of Science and Culture)
Background WNT and TGFβ signaling pathways play critical regulatory roles in cardiomyocyte fate determination and differentiation. MiRNAs are also known to regulate different biological processes and signaling pathways. Here, we intended to find candidate miRNAs that are involved in cardiac differentiation through regulation of WNT and TGFβ signaling pathways.
Published on Sep 1, 2019in Differentiation 3.02
Ehsan Ehsani5
Estimated H-index: 5
(IAU: Islamic Azad University),
Soroosh Shekarchian3
Estimated H-index: 3
(Royan Institute)
+ 2 AuthorsReza Moghadasali10
Estimated H-index: 10
(Royan Institute)
Abstract End-stage renal disease (ESRD) is a major global public health issue. In the past decade, regenerative medicine and cell-based therapies were recommended for treatment of devastating diseases like ESRD. Renal progenitor (RP) cells are essential players in such treatment approaches. The major practical difficulties in application of RP cells are generation of these cells and preservation of their self-renewal capacity; also, they should lack identified appropriate cell surface markers. T...
Published on Aug 1, 2019in Materials Science and Engineering: C 4.96
Amir Kamali5
Estimated H-index: 5
(Shiraz University),
Ahmad Oryan30
Estimated H-index: 30
(Shiraz University)
+ 4 AuthorsHossein Baharvand42
Estimated H-index: 42
(Royan Institute)
Abstract Recruitment of mesenchymal stem cells (MSCs) to an injury site and their differentiation into the desired cell lineage are implicated in deficient bone regeneration. To date, there is no ideal structure that provides these conditions for bone regeneration. In the current study, we aim to develop a novel scaffold that induces MSC migration towards the defect site, followed by their differentiation into an osteogenic lineage. We have fabricated a gelatin/nano-hydroxyapatite (G/nHAp) scaff...
Published on Jul 15, 2019in Oncogene 6.63
R khoshchehreh1
Estimated H-index: 1
(University of Science and Culture),
Mehdi Totonchi14
Estimated H-index: 14
(Royan Institute)
+ 5 AuthorsChristopher Heeschen59
Estimated H-index: 59
Pancreatic ductal adenocarcinoma (PDAC) arises through accumulation of multiple genetic alterations. However, cancer cells also acquire and depend on cancer-specific epigenetic changes. To conclusively demonstrate the crucial relevance of the epigenetic programme for the tumourigenicity of the cancer cells, we used cellular reprogramming technology to reverse these epigenetic changes. We reprogrammed human PDAC cultures using three different techniques – (1) lentivirally via induction of Yamanak...
Published on Jun 1, 2019in Experimental Cell Research 3.33
Zohreh Mansoori-Moghadam (University of Science and Culture), Mehdi Totonchi14
Estimated H-index: 14
(Royan Institute)
+ 3 AuthorsReza Moghadasali10
Estimated H-index: 10
(Royan Institute)
Abstract This study aims to prepare intermediate mesoderm-like cells from mouse embryonic fibroblasts (MEFs). In the first step, intermediate mesoderm-like cells (IMLCs) and renal epithelial-like cells (RELCs) were extracted from mouse embryonic stem cells (mESCs) in a specified media that contained two small molecules, CHIR99021 and TTNPB, along with growth factors, FGF9and BMP7. Then, MEFs were directly converted into IM by genes for the pluripotency factors, which encode the transcription fac...
Published on Jun 1, 2019in Journal of Cellular Physiology 4.52
Mardpour Soura7
Estimated H-index: 7
(Tehran University of Medical Sciences),
Amir Ali Hamidieh10
Estimated H-index: 10
(Tehran University of Medical Sciences)
+ 3 AuthorsHossein Baharvand5
Estimated H-index: 5
(University of Science and Culture)
Published on Jun 1, 2019in International Journal of Pharmaceutics 4.21
Fatemeh Radmanesh1
Estimated H-index: 1
Hamid Sadeghi Abandansari9
Estimated H-index: 9
+ 5 AuthorsBahram Kazemi
Abstract Safe and efficient delivery of microRNA (miRNA) molecules is essential for their successful transition from research to the clinic setting. In the present study, we have used a bile acid, deoxycholic acid (DA), to modify 1.8 kDa branched polyethylenimine (bPEI 1.8 ) and subsequently investigated gene delivery features of the resultant conjugates (PEI-DA n ). We found significant differences between the PEI-DA n conjugates and conventional bPEIs with respect to miRNA condensation ability...
Published on Jun 1, 2019in Archives of Iranian Medicine 1.14
Samaneh Saberi5
Estimated H-index: 5
Razieh Karamzadeh6
Estimated H-index: 6
+ 6 AuthorsMassoud Vosough8
Estimated H-index: 8
Background: Accomplishments in stem cell science and tissue engineering have resulted in a remarkable revolution in the context of future medicine. However, a general insight over the progress of stem cell research in Iran is still lacking. A better understanding of current needs in this field is required to design a better national roadmap. Methods: In this study, we defined the geographical regions based on the significance of their contribution to stem cell research; then, using the Scopus da...
Published on Jun 1, 2019in Trends in Biotechnology 13.75
Zahra Shiri (Royan Institute), Susan Simorgh (Royan Institute)+ 1 AuthorsHossein Baharvand42
Estimated H-index: 42
(University of Science and Culture)
The human brain has been deemed the most complex organ and has captivated neuroscientists for decades. Most studies of this organ have relied on reductionist model systems. Although all model systems are essentially wrong, cerebral organoids so far represent the closest recapitulation of human brain development and disease both in terms of cell diversity and organization. The optogenetic technique can be used in this context to study the functional neuroanatomy of the brain, to examine the neura...