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Pritam Sinharoy
Kent State University
7Publications
5H-index
56Citations
Publications 7
Newest
#1Spencer R. Andrei (VUMC: Vanderbilt University Medical Center)H-Index: 3
#2Monica Ghosh (KSU: Kent State University)H-Index: 1
Last.Derek S. Damron (KSU: Kent State University)H-Index: 8
view all 4 authors...
ABSTRACTThe functional expression of transient receptor potential cation channel of the ankyrin-1 subtype (TRPA1) has recently been identified in adult mouse cardiac tissue where stimulation of this ion channel leads to increases in adult mouse ventricular cardiomyocyte (CM) contractile function via a Ca2+-Calmodulin-dependent kinase (CaMKII) pathway. However, the extent to which TRPA1 induces nitric oxide (NO) production in CMs, and whether this signaling cascade mediates physiological or patho...
#1Pritam Sinharoy (Stanford University)H-Index: 5
#2Stacy L. McAllister (Stanford University)H-Index: 5
Last.Eric R. Gross (Stanford University)H-Index: 29
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Aldehydes, which are present within the air as well as food and beverage sources, are highly reactive molecules that can be cytotoxic, mutagenic, and carcinogenic. To prevent harm from reactive aldehyde exposure, the enzyme aldehyde dehydrogenase 2 (ALDH2) metabolizes reactive aldehydes to a less toxic form. However, the genetic variant of ALDH2, ALDH2*2, significantly reduces the ability to metabolize reactive aldehydes in humans. Therefore, frequent environmental aldehyde exposure, coupled wit...
#1Leonie G.M. Wijermars (LUMC: Leiden University Medical Center)H-Index: 4
#2Alexander F. Schaapherder (LUMC: Leiden University Medical Center)H-Index: 32
Last.Eric R. Gross (Stanford University)H-Index: 29
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Delayed graft function is an early complication following kidney transplantation with an unclear molecular mechanism. Here we determined whether impaired reactive aldehyde metabolism is associated with delayed graft function. Human kidney biopsies from grafts with delayed graft function were compared with grafts that did not develop delayed graft function by Ingenuity gene pathway analysis. A second series of grafts with delayed graft function () were compared to grafts that did not develop dela...
#1Michael Sulak (U of C: University of Chicago)H-Index: 5
#2Monica Ghosh (KSU: Kent State University)H-Index: 1
Last.Derek S. Damron (KSU: Kent State University)H-Index: 8
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ABSTRACTTransient receptor potential cation channel, subfamily A, member 1 (TRPA1), is activated by a broad range of noxious stimuli. Cdk5, a member of the Cdk family, has recently been identified as a modulator of pain signaling pathways. In the current study, we investigated the extent to which Cdk5 modulates TRPA1 activity. Cdk5 inhibition was found to attenuate TRPA1 response to agonist in mouse DRG sensory neurons. Additionally, the presence of active Cdk5 was associated with increased TRPA...
#1Spencer R. Andrei (VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Monica Ghosh (KSU: Kent State University)H-Index: 1
Last.Derek S. Damron (KSU: Kent State University)H-Index: 8
view all 6 authors...
ABSTRACTRationale: Transient receptor potential channels of the ankyrin subtype-1 (TRPA1) are non-selective cation channels that show high permeability to calcium. Previous studies from our laboratory have demonstrated that TRPA1 ion channels are expressed in adult mouse ventricular cardiomyocytes (CMs) and are localized at the z-disk, costamere and intercalated disk. The functional significance of TRPA1 ion channels in the modulation of CM contractile function have not been explored.Objective: ...
#1Pritam Sinharoy (Stanford University)H-Index: 2
#2Ian N. BratzH-Index: 19
Last.Derek S. Damron (KSU: Kent State University)H-Index: 8
view all 6 authors...
Background Transient receptor potential (TRP) ion channels have emerged as key components contributing to vasoreactivity. Propofol, an anesthetic is associated with adverse side effects including hypotension and acute pain upon infusion. Our objective was to determine the extent to which TRPA1 and/or TRPV1 ion channels are involved in mediating propofol-induced vasorelaxation of mouse coronary arterioles in vitro and elucidate the potential cellular signal transduction pathway by which this occu...
#1Daniel J. DelloStritto (NEOMED: Northeast Ohio Medical University)H-Index: 4
#2Pritam Sinharoy (KSU: Kent State University)H-Index: 5
Last.Ian N. Bratz (NEOMED: Northeast Ohio Medical University)H-Index: 19
view all 9 authors...
Abstract We demonstrated previously that TRPV1-dependent regulation of coronary blood flow (CBF) is disrupted in diabetes. Further, we have shown that endothelial TRPV1 is differentially regulated, ultimately leading to the inactivation of TRPV1, when exposed to a prolonged pathophysiological oxidative environment. This environment has been shown to increase lipid peroxidation byproducts including 4-Hydroxynonenal (4-HNE). 4-HNE is notorious for producing protein post-translation modification (P...
#1Igor A. Schepetkin (MSU: Montana State University)H-Index: 23
Last.Anastasia R. Kovrizhina (Tomsk Polytechnic University)H-Index: 1
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Essential oils were obtained by hydrodistillation of the umbels+seeds and stems of Ferula akitschkensis (FAEOu/s and FAEOstm, respectively) and analyzed by gas chromatography and gas chromatography–mass spectrometry. Fifty-two compounds were identified in FAEOu/s; the primary components were sabinene, α-pinene, β-pinene, terpinen-4-ol, eremophilene, and 2-himachalen-7-ol, whereas the primary components of FAEOstm were myristicin and geranylacetone. FAEOu/s, β-pinene, sabinene, γ-terpinene, geran...
#1Spencer R. Andrei (KSU: Kent State University)H-Index: 3
#2Pritam Sinharoy (KSU: Kent State University)H-Index: 5
Last.Derek S. Damron (KSU: Kent State University)H-Index: 8
view all 4 authors...
ABSTRACTTransient receptor potential channels of the ankyrin subtype-1 (TRPA1) and vanilloid subtype-1 (TRPV1) are structurally related, non-selective cation channels that show a high permeability to calcium. Previous studies indicate that TRP channels play a prominent role in the regulation of cardiovascular dynamics and homeostasis, but also contribute to the pathophysiology of many diseases and disorders within the cardiovascular system. However, no studies to date have identified the functio...
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