Carmine M. Pariante
King's College London
PsychiatryEndocrinologyPsychologyPsychosisClinical psychology
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Publications 667
#1N. Nikkheslat ('KCL': King's College London)H-Index: 7
#2Anna McLaughlin ('KCL': King's College London)H-Index: 3
Last. Valeria MondelliH-Index: 39
view all 15 authors...
Abstract Childhood trauma is among the most potent contributing risk factors for depression and is associated with poor treatment response. Hypothalamic-pituitary-adrenal (HPA) axis abnormalities have been linked to both childhood trauma and depression, but the underlying mechanisms are poorly understood. The present study aimed to investigate the link between childhood trauma, HPA axis activity and antidepressant response in patients with depression. As part of the Wellcome Trust NIMA consortiu...
#1Federico Turkheimer ('KCL': King's College London)H-Index: 60
Last. Mattia VeroneseH-Index: 19
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The relationship between peripheral and central immunity and how these ultimately may cause depressed behaviour has been the focus of a number of imaging studies conducted with Positron Emission Tomography (PET). These studies aimed at testing the immune-mediated model of depression that proposes a direct effect of peripheral cytokines and immune cells on the brain to elicit a neuroinflammatory response via a leaky blood-brain barrier and ultimately depressive behaviour. However, studies conduct...
#1Julia Johanna Schubert ('KCL': King's College London)H-Index: 1
#2Mattia Veronese ('KCL': King's College London)H-Index: 19
Last. Edward T. Bullmore (University of Cambridge)H-Index: 146
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BACKGROUND Immune mechanisms have been implicated in the pathogenesis of depression, and translocator-protein (TSPO) targeted positron emission tomography (PET) has been used to assess neuroinflammation in major depressive disorder. We aimed to: (i) test the prior hypothesis of significant case-control differences in TSPO binding in anterior cingulate (ACC), prefrontal (PFC) and insular (INS) cortical regions; and (ii) explore the relationship between cerebral TSPO binding and peripheral blood c...
1 CitationsSource
#1Carmine M. ParianteH-Index: 80
#2Gayle M. Wittenberg (Janssen Pharmaceutica)H-Index: 16
Last. Wayne C. Drevets (Janssen Pharmaceutica)H-Index: 89
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Activation of the innate immune system is commonly associated with depression. Immunomodulatory drugs may have efficacy for depressive symptoms that are co-morbidly associated with inflammatory disorders. We report a large-scale re-analysis by standardized procedures (mega-analysis) of patient-level data combined from 18 randomized clinical trials conducted by Janssen or GlaxoSmithKline for one of nine disorders (N = 10,743 participants). Core depressive symptoms (low mood, anhedonia) were measu...
8 CitationsSource
#1Alessandra Borsini ('KCL': King's College London)H-Index: 9
#2Amelia St John Wallis ('KCL': King's College London)
Last. Matthew J. Kempton ('KCL': King's College London)H-Index: 34
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Anhedonia is a key symptom of major depressive disorder (MDD) and comprises behavioural deficits in three reward processing subtypes: reward liking, reward wanting, and reward learning. However, neuroimaging findings regarding the neural abnormalities underpinning these deficits are complex. We have conducted a systematic review to update, reframe and summarize neuroimaging findings across the three subtypes of anhedonia in MDD. Using PubMed, The Cochrane Library, PsycINFO, and Web of Science da...
#1Simone Ciufolini ('KCL': King's College London)H-Index: 7
#2Matthew J. Kempton ('KCL': King's College London)H-Index: 34
Last. C.W. Morgan ('KCL': King's College London)H-Index: 61
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#2Carlo Maj (University Hospital Bonn)H-Index: 4
Last. Nadia CattaneH-Index: 11
view all 9 authors...
MicroRNAs (miRNAs), one of the major small non-coding RNA classes, have been proposed as regulatory molecules in neurodevelopment and stress response. Although alterations in miRNAs profiles have been implicated in several psychiatric and neurodevelopmental disorders, the contribution of individual miRNAs in brain development and function is still unknown. Recent studies have identified miR-19 as a key regulator of brain trajectories, since it drives the differentiation of neural stem cells into...
#1Jane Pei-Chen Chang (PRC: China Medical University (PRC))H-Index: 11
#2Valeria Mondelli ('KCL': King's College London)H-Index: 39
Last. Carmine M. Pariante ('KCL': King's College London)H-Index: 80
view all 7 authors...
Abstract Background Hypothalamus-Pituitary-Adrenal (HPA) axis dysregulation, inflammation and imbalance of neurotrophins have been suggested in attention deficit hyperactivity disorder (ADHD), but the results have not been conclusive. The aim of this study is to investigate the levels of salivary cortisol across 4-time points during the day, and of morning plasma inflammatory biomarkers and neurotrophins, in youth with ADHD and in typically developing youth (TD), with stratification by age, ADHD...
#1Nadia CattaneH-Index: 11
#2V. BegniH-Index: 4
Last. Annamaria CattaneoH-Index: 30
view all 6 authors...