Marianne Böni-Schnetzler
University of Basel
EndocrinologyType 2 diabetesInsulinDiabetes mellitusBiology
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Publications 34
#1Matthias Hepprich (University of Basel)H-Index: 1
#2Sophia J. Wiedemann (University of Basel)
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 10 authors...
Summary Postprandial hypoglycemia is a disabling complication of the treatment of obesity by gastric bypass surgery. So far, no therapy exists, and the underlying mechanisms remain unclear. Here, we hypothesized that glucose-induced IL-1β leads to an exaggerated insulin response in this condition. Therefore, we conducted a placebo-controlled, randomized, double-blind, crossover study with the SGLT2-inhibitor empagliflozin and the IL-1 receptor antagonist anakinra ( NCT03200782...
#1Friederike Schulze (University of Basel)H-Index: 4
#2Josua Wehner (University of Basel)
Last. Sophia J. Wiedemann (University of Basel)
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Gestational diabetes mellitus (GDM) is one of the most common diseases associated with pregnancy, however, the underlying mechanisms remain unclear. Based on the well documented role of inflammation in type 2 diabetes, the aim was to investigate the role of inflammation in GDM. We established a mouse model for GDM on the basis of its two major risk factors, obesity and aging. In these GDM mice, we observed increased Interleukin-1β (IL-1β) expression in the uterus and the placenta along with elev...
#1Urszula Brykczynska (ETH Zurich)
#2Marco Geigges (ETH Zurich)H-Index: 1
Last. Renato Paro (University of Basel)H-Index: 27
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Summary The innate immune system safeguards the organism from both pathogenic and environmental stressors. Also, physiologic levels of nutrients affect organismal and intra-cellular metabolism and challenge the immune system. In the long term, over-nutrition leads to low-grade systemic inflammation. Here, we investigate tissue-resident components of the innate immune system (macrophages) and their response to short- and long-term nutritional challenges. We analyze the transcriptomes of six tissu...
#1Helga EllingsgaardH-Index: 13
#2Eleonora SeeligH-Index: 5
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 14 authors...
Aims/hypothesis IL-6 is a cytokine with various effects on metabolism. In mice, IL-6 improved beta cell function and glucose homeostasis via upregulation of glucagon-like peptide 1 (GLP-1), and IL-6 release from muscle during exercise potentiated this beneficial increase in GLP-1. This study aimed to identify whether exercise-induced IL-6 has a similar effect in humans.
1 CitationsSource
#1Marc Y. Donath (University of Basel)H-Index: 60
#2Daniel T. Meier (University of Basel)H-Index: 2
Last. Marianne Böni-Schnetzler (University of Basel)H-Index: 18
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: The role of chronic inflammation in the pathogenesis of type 2 diabetes mellitus and associated complications is now well established. Therapeutic interventions counteracting metabolic inflammation improve insulin secretion and action and glucose control and may prevent long-term complications. Thus, a number of anti-inflammatory drugs approved for the treatment of other inflammatory conditions are evaluated in patients with metabolic syndrome. Most advanced are clinical studies with IL-1 anta...
#1Marianne Böni-Schnetzler (University Hospital of Basel)H-Index: 2
#2Daniel T. Meier (University Hospital of Basel)H-Index: 1
Metabolic diseases including type 2 diabetes are associated with meta-inflammation. β-Cell failure is a major component of the pathogenesis of type 2 diabetes. It is now well established that increased numbers of innate immune cells, cytokines, and chemokines have detrimental effects on islets in these chronic conditions. Recently, evidence emerged which points to initially adaptive and restorative functions of inflammatory factors and immune cells in metabolism. In the following review, we prov...
2 CitationsSource
#1Matthias HepprichH-Index: 1
Last. Marc Y. DonathH-Index: 60
view all 6 authors...
Background: Postprandial hypoglycemia (PPH) is a debilitating complication after bariatric surgery, due to an exaggerated hyperinsulinemic response after carbohydrate ingestion. Recent studies have shown that IL-1β contributes to the postprandial stimulation of insulin. Similarly, lowering hyperglycemic peak by SGLT2-inhibition may reduce insulin secretion. We investigated whether the IL-1 receptor antagonist anakinra or empagliflozin influence PPH in patients after gastric bypass. Methods: We i...
#1Marianne Böni-Schnetzler (University of Basel)H-Index: 18
#2Stéphanie P. Häuselmann (University of Basel)H-Index: 5
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 13 authors...
Summary Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knockout (KO) mice. Deletion of IL-1Ra in β cells, but not in myeloid cells, resulted in diminished islet IL-1Ra expression. Myeloid cells were not the main source of circulatin...
10 CitationsSource
#1Stephan Wueest (Boston Children's Hospital)H-Index: 15
#2Céline I. Laesser (Boston Children's Hospital)H-Index: 1
Last. Daniel Konrad (UZH: University of Zurich)H-Index: 24
view all 9 authors...
We recently showed that interleukin (IL)-6-type cytokine signaling in adipocytes induces free fatty acid release from visceral adipocytes, thereby promoting obesity-induced hepatic insulin resistance and steatosis. In addition, IL-6-type cytokines may increase the release of leptin from adipocytes and by those means induce glucagon-like peptide 1 (GLP-1) secretion. We thus hypothesized that IL-6-type cytokine signaling in adipocytes may regulate insulin secretion. To this end, mice with adipocyt...
10 CitationsSource
#1Thierry M. Nordmann (University of Basel)H-Index: 3
#2Erez Dror (University of Basel)H-Index: 7
Last. Marc Y. Donath (University of Basel)H-Index: 60
view all 8 authors...
Chronic inflammation impairs insulin secretion and sensitivity. β-cell dedifferentiation has recently been proposed as a mechanism underlying β-cell failure in T2D. Yet the effect of inflammation on β-cell identity in T2D has not been studied. Therefore, we investigated whether pro-inflammatory cytokines induce β-cell dedifferentiation and whether anti-inflammatory treatments improve insulin secretion via β-cell redifferentiation. We observed that IL-1β, IL-6 and TNFα promote β-cell dedifferenti...
23 CitationsSource