Sergio A. Muñoz-Gómez
Dalhousie University
17Publications
6H-index
151Citations
Publications 17
Newest
Published on Feb 21, 2019in eLife 7.62
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University),
Sebastian Hess1
Estimated H-index: 1
(Dalhousie University)
+ 4 AuthorsAndrew J. Roger52
Estimated H-index: 52
(Dalhousie University)
The Alphaproteobacteria is an extraordinarily diverse and ancient group of bacteria. Previous attempts to infer its deep phylogeny have been plagued with methodological artefacts. To overcome this, we analyzed a dataset of 200 single-copy and conserved genes and employed diverse strategies to reduce compositional artefacts. Such strategies include using novel dataset-specific profile mixture models and recoding schemes, and removing sites, genes and taxa that are compositionally biased. We show ...
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Published on Apr 26, 2018in eLife 7.62
Courtney W. Stairs10
Estimated H-index: 10
(Dalhousie University),
Laura Eme15
Estimated H-index: 15
(Dalhousie University)
+ 5 AuthorsAndrew J. Roger52
Estimated H-index: 52
(Dalhousie University)
2 Citations Source Cite
Published on Nov 1, 2018in Current Biology 9.25
Jeremy G. Wideman12
Estimated H-index: 12
(Dalhousie University),
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University)
Summary The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that mitochondria of trypanosomatid parasites bear a divergent MICOS with both ancestral and derived subunits, but with conserved functions in crista development and membrane contact-site formation.
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Published on Jun 1, 2017in Current Biology 9.25
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University),
Fabian G. Mejía-Franco1
Estimated H-index: 1
+ 4 AuthorsClaudio H. Slamovits26
Estimated H-index: 26
(Canadian Institute for Advanced Research)
Summary Red algal plastid genomes are often considered ancestral and evolutionarily stable, and thus more closely resembling the last common ancestral plastid genome of all photosynthetic eukaryotes [1, 2]. However, sampling of red algal diversity is still quite limited (e.g., [2–5]). We aimed to remedy this problem. To this end, we sequenced six new plastid genomes from four undersampled and phylogenetically disparate red algal classes (Porphyridiophyceae, Stylonematophyceae, Compsopogonophycea...
30 Citations Source Cite
Published on Nov 1, 2017in Current Biology 9.25
Andrew J. Roger52
Estimated H-index: 52
(Dalhousie University),
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University),
Ryoma Kamikawa14
Estimated H-index: 14
(Kyoto University)
Summary Mitochondria are best known for their role in the generation of ATP by aerobic respiration. Yet, research in the past half century has shown that they perform a much larger suite of functions and that these functions can vary substantially among diverse eukaryotic lineages. Despite this diversity, all mitochondria derive from a common ancestral organelle that originated from the integration of an endosymbiotic alphaproteobacterium into a host cell related to Asgard Archaea. The transitio...
38 Citations Source Cite
Published on Jan 12, 2017in Molecular Biology and Evolution 10.22
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University),
Jeremy G. Wideman12
Estimated H-index: 12
(University of Exeter)
+ 1 AuthorsClaudio H. Slamovits26
Estimated H-index: 26
(Canadian Institute for Advanced Research)
10 Citations Source Cite
Published on Aug 1, 2016in Biochimica et Biophysica Acta 3.44
Jeremy G. Wideman12
Estimated H-index: 12
(University of Exeter),
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University)
Abstract The ER–mitochondria organizing network (ERMIONE) in Saccharomyces cerevisiae is involved in maintaining mitochondrial morphology and lipid homeostasis. ERMES and MICOS are two scaffolding complexes of ERMIONE that contribute to these processes. ERMES is ancient but has been lost in several lineages including animals, plants, and SAR (stramenopiles, alveolates and rhizaria). On the other hand, MICOS is ancient and has remained present in all organisms bearing mitochondrial cristae. The E...
21 Citations Source Cite
Published on Aug 31, 2016in eLife 7.62
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University),
Andrew J. Roger52
Estimated H-index: 52
(Dalhousie University)
Bacteria with a single cell membrane have evolved from ancestors with two membranes on multiple occasions within the Firmicutes phylum.
2 Citations Source Cite
Published on Jun 1, 2015in Current Biology 9.25
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University),
Claudio H. Slamovits26
Estimated H-index: 26
(Canadian Institute for Advanced Research)
+ 3 AuthorsJeremy G. Wideman12
Estimated H-index: 12
(University of Alberta)
Summary Mitochondria are eukaryotic organelles that originated from an endosymbiotic α-proteobacterium. As an adaptation to maximize ATP production through oxidative phosphorylation, mitochondria contain inner membrane invaginations called cristae. Recent work has characterized a multi-protein complex in yeast and animal mitochondria called MICOS (mitochondrial contact site and cristae organizing system), responsible for the determination and maintenance of cristae [1–4]. However, the origin and...
30 Citations Source Cite
Published on Nov 2, 2015in Communicative & Integrative Biology
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University),
Claudio H. Slamovits26
Estimated H-index: 26
(Canadian Institute for Advanced Research)
+ 1 AuthorsJeremy G. Wideman12
Estimated H-index: 12
(University of Exeter)
The MItochondrial Contact Site and Cristae Organizing System (MICOS) is required for the biogenesis and maintenance of mitochondrial cristae as well as the proper tethering of the mitochondrial inner and outer membranes. We recently demonstrated that the core components of MICOS, Mic10 and Mic60, are near-ubiquitous eukaryotic features inferred to have been present in the last eukaryote common ancestor. We also showed that Mic60 could be traced to α-proteobacteria, which suggests that mitochondr...
12 Citations Source Cite
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