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Derek Zieker
University of Tübingen
71Publications
19H-index
1,120Citations
Publications 71
Newest
Published on Oct 1, 2016in Journal of Hepatology 15.04
Markus Loeffler77
Estimated H-index: 77
(University of Tübingen),
P. Anoop Chandran2
Estimated H-index: 2
(University of Tübingen)
+ 28 AuthorsHeiko Schuster13
Estimated H-index: 13
(University of Tübingen)
Background & Aims We report a novel experimental immunotherapeutic approach in a patient with metastatic intrahepatic cholangiocarcinoma. In the 5year course of the disease, the initial tumor mass, two local recurrences and a lung metastasis were surgically removed. Lacking alternative treatment options, aiming at the induction of anti-tumor T cells responses, we initiated a personalized multi-peptide vaccination, based on in-depth analysis of tumor antigens (immunopeptidome) and sequencing. Met...
21 Citations Source Cite
Rami Archid3
Estimated H-index: 3
,
T Kratt10
Estimated H-index: 10
+ 5 AuthorsJörg Glatzle20
Estimated H-index: 20
Ectopic pancreas is a benign congenital abnormality, defined as pancreatic tissue that lacks anatomic or vascular continuity to the pancreas. An incidence of 0.55%-13% has been described in autopsy studies. Ectopic pancreas is most commonly found in the upper GI-Tract.
Source Cite
Rami Archid3
Estimated H-index: 3
,
Carl Christoph Schneider2
Estimated H-index: 2
+ 3 AuthorsAlfred Königsrainer42
Estimated H-index: 42
Introduction Hemangiopericytoma (HPC) has been first described in 1942 by Stout as a tumor originating from the capillary surrounding pericytes. It is known to occur in any anatomical site, especially the extremities and retroperitoneum.
1 Citations Source Cite
Published on Dec 1, 2015in Anticancer Research 1.86
Katharina Schmidt15
Estimated H-index: 15
(University of Regensburg),
Christian Moser16
Estimated H-index: 16
(University of Regensburg)
+ 6 AuthorsSven A. Lang23
Estimated H-index: 23
(University of Regensburg)
Abstract To assess the efficacy of targeting fibroblast growth factor receptor (FGFR) with the pan-FGFR inhibitor BGJ398 in a gastric cancer (GC) model. Expression of FGFRs was determined in GC cell lines (KKLS, MKN-45, TMK-1). Impact of the FGFR inhibitor BGJ398 on growth, motility, signaling, expression of transcription factors and secretion of vascular endothelial growth factor-A (VEGFA) was determined in vitro. Results were validated in subcutaneous tumor models. In vitro, FGFR inhibition wa...
7 Citations Source Cite
Published on Oct 1, 2015in International Journal of Surgery
Carl Christoph Schneider2
Estimated H-index: 2
(University of Tübingen),
Rami Archid3
Estimated H-index: 3
(University of Tübingen)
+ 9 AuthorsAlfred Königsrainer42
Estimated H-index: 42
(University of Tübingen)
Abstract Background and Objectives It can be assumed that PGK1 is involved in metastatic spread of gastric carcinomas. Furthermore PGK1 has a proven influence on the characteristics of tumor stem cells. The presence of malignant stem cells, regarding treatment resistance and recurrence, is of considerable importance. We hypothesized that inhibition of PGK1 makes these cells more sensitive to chemotherapeutic agents and therefore mediates an overcome of the existing therapy resistance. Methods Al...
4 Citations Source Cite
Published on Apr 1, 2015in International Surgery 0.58
Tobias Meile10
Estimated H-index: 10
,
Derek Zieker19
Estimated H-index: 19
+ 1 AuthorsJörg Glatzle20
Estimated H-index: 20
To perform stress-free recording of gastrointestinal motility in rats with strain gauge transducers, telemetry equipment had to be developed. We developed, programmed, and tested a new telemetry device that records gastrointestinal motility in freely moving rats using strain gauge transducers. The device can collect and transmit data in freely moving rats. Data are received and stored for later analysis with a regular PC. Linear calibration curves were obtained for the strain gauge transducers u...
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Published on Mar 30, 2015in PLOS ONE 2.77
Fabian Stuby10
Estimated H-index: 10
(University of Tübingen),
Stefan Döbele7
Estimated H-index: 7
(University of Tübingen)
+ 4 AuthorsDerek Zieker19
Estimated H-index: 19
(University of Tübingen)
Introduction This study was conducted according to GCP criteria as a prospective randomized cross-over study. The primary goal of the study was to determine clinical findings and patient satisfaction with postoperative treatment. 29 patients with a distal radius fracture that was surgically stabilized from volar and who met the inclusion criteria were enrolled over a 12-month period. Each patient randomly received either a dorsal plaster splint or a vacuum-fit flexible but blocked orthosis appli...
6 Citations Source Cite
Published on May 1, 2014in Zeitschrift Fur Gastroenterologie 1.61
F. Eisner1
Estimated H-index: 1
(University of Tübingen),
M Küper16
Estimated H-index: 16
+ 3 AuthorsJörg Glatzle20
Estimated H-index: 20
(University of Tübingen)
Introduction: Patients with Crohn’s disease [CD] carry an 80 − 90 % lifetime risk of undergoing surgery. Many of these patients are on immunosuppressive medication at the time of surgery. The aim of this study was to evaluate the effect of immunosuppression on the surgical outcome in CD patients. Methods: We retrospectively analyzed 484 consecutive abdominal operations for CD from 1995 to 2008 for surgical complications. Results: A total of 241 operations (= 49.8 %) were performed under perioper...
2 Citations Source Cite
Published on Feb 1, 2014in Surgery Today 2.50
Ingmar Königsrainer19
Estimated H-index: 19
(University of Tübingen),
Derek Zieker19
Estimated H-index: 19
(University of Tübingen)
+ 3 AuthorsStefan Beckert17
Estimated H-index: 17
(University of Tübingen)
Purpose In pancreatic cancer, the presence of peritoneal carcinomatosis (PC) precludes the possibility of a surgical cure, irrespective of the resectability of the primary tumor. However, peritoneal spread cannot be reliably detected radiographically during preoperative tumor staging.
8 Citations Source Cite
Published on Nov 15, 2013in Zentralblatt Fur Chirurgie 0.42
Stefan Beckert17
Estimated H-index: 17
,
Florian Struller5
Estimated H-index: 5
+ 4 AuthorsIngmar Königsrainer19
Estimated H-index: 19
Eine Metastasierung in das viszerale oder parietale Peritoneum (Peritonealkarzinose) wird nach wie vor als terminales Krankheitsstadium angesehen. Stimuliert durch die Pionierarbeit von Prof. Dr. Paul Sugarbaker wurde das Konzept der Peritonektomie in Form einer maximalen Zytoreduktion (ZRS) mit intraoperativer hyperthermer Chemotherapie (HIPEC) entwickelt, wodurch sich die Uberlebenszeit, verglichen mit alleiniger systemischer Chemotherapie, bei selektionierten Patienten nahezu verdoppeln lies....
2 Citations Source Cite
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