Thomas Thymann
University of Copenhagen
EndocrinologyNecrotizing enterocolitisDiabetes mellitusMedicineParenteral nutrition
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Publications 147
#1Lee Call (ARS: Agricultural Research Service)
#2Tiffany L. Molina (BCM: Baylor College of Medicine)H-Index: 1
Last. Mahmoud A Mohammad (ARS: Agricultural Research Service)H-Index: 3
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Multi-component lipid emulsions, rather than soy-oil emulsions, prevent cholestasis by an unknown mechanism. Here, we quantified liver function, bile acid pools, and gut microbial and metabolite profiles in premature, parenterally fed pigs given a soy-oil lipid emulsion, Intralipid (IL); a multi component lipid emulsion, SMOFlipid (SMOF); a novel emulsion with a modified fatty-acid composition (EXP); or a control enteral diet (ENT) for 22 days. We assayed serum cholestasis markers; measured tota...
#1Marit Navis (UvA: University of Amsterdam)H-Index: 1
#2Vanesa Muncan (UvA: University of Amsterdam)H-Index: 17
Last. Ingrid B. Renes (Boston Children's Hospital)H-Index: 22
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Background. The human digestive tract is structurally mature at birth, yet maturation of gut functions such as digestion and mucosal barrier continues for the next 1–2 years. Human milk and infant milk formulas (IMF) seem to impact maturation of these gut functions differently, which is at least partially related to high temperature processing of IMF causing loss of bioactive proteins and formation of advanced glycation end products (AGEs). Both loss of protein bioactivity and formation of AGEs ...
#1Xiaoyu PanH-Index: 3
#2Thomas ThymannH-Index: 25
Last. Per T. SangildH-Index: 38
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Following preterm birth, the immature gut function and immunology must rapidly adapt to cope with bacterial colonization and enteral milk feeding. We hypothesized that intestinal epigenetic changes are involved in the gut response to preterm birth and the first feeding. Using piglets as models for infants, preterm, and term pigs were fed total parenteral nutrition (TPN) or partial enteral feeding for 5 days, followed by exclusive enteral feeding with bovine milk until day 26 (weaning age). Intes...
#1C. Amdi (UCPH: University of Copenhagen)H-Index: 6
#2Julie C Lynegaard (UCPH: University of Copenhagen)
Last. Andrew R. Williams (UCPH: University of Copenhagen)H-Index: 12
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Large litter sizes have resulted in more piglets being exposed to intrauterine growth restriction (IUGR). Growth restriction during fetal life is linked with lower growth efficiency and increased susceptibility to infections in postnatal life and IUGR may associate with an altered innate immune system. We investigated the haematological, thromboelastography and plasma biochemical profiles of IUGR and normal piglets as well as cytokine responses in peripheral blood mononuclear cells stimulated wi...
#1Susanne Soendergaard Kappel (UCPH: University of Copenhagen)
#2Per T. Sangild (UCPH: University of Copenhagen)H-Index: 38
Last. Lise Aunsholt (Copenhagen University Hospital)
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BACKGROUND: Necrotizing enterocolitis (NEC) is a serious intestinal inflammatory disease in preterm infants. High volume of gastric residual (GR) after oral feedings is often used as a predictor of NEC, but evidence is limited. Using NEC-sensitive preterm piglets as models, we hypothesized that GR mass and related plasma biomarkers predict early onset of NEC. METHODS: In total, 258 newborn preterm piglets were fed bovine milk-based formulas for 5 days. At euthanasia, the stomach, small intestine...
#1Agnethe M. Ahnfeldt (UCPH: University of Copenhagen)
#2Ole Bæk (UCPH: University of Copenhagen)H-Index: 1
Last. Douglas G. Burrin (BCM: Baylor College of Medicine)H-Index: 59
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BACKGROUND: Extrauterine growth restriction (EUGR) in preterm infants is associated with higher morbidity and impaired neurodevelopment. Early nutrition support may prevent EUGR in preterm infants, but it is not known if this improves organ development and brain function in the short and long term. OBJECTIVE: Using pigs as models for infants, we hypothesized that diet-induced EUGR impairs gut, immunity, and brain development in preterm neonates during the first weeks after birth. METHODS: Forty-...
#1Douglas G. Burrin (BCM: Baylor College of Medicine)H-Index: 59
#2Per T. Sangild (UCPH: University of Copenhagen)H-Index: 38
Last. Robert J. Shulman (BCM: Baylor College of Medicine)H-Index: 39
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Pigs are increasingly important animals for modeling human pediatric nutrition and gastroenterology and complementing mechanistic studies in rodents. The comparative advantages in size and physiolo...
#1Victoria Smith (California Polytechnic State University)H-Index: 1
#1Victoria SmithH-Index: 1
Last. Douglas G. BurrinH-Index: 59
view all 7 authors...
OBJECTIVES: Bile acid (BA) homeostasis is regulated by intestinal cellular signaling involving the farnesoid X receptor (FXR) and fibroblast growth factor 19 (FGF19) secretion. Using preterm and term pigs as a model, we examined postnatal changes in expression of the FXR-FGF19 axis that is poorly characterized in human infants. METHODS: Pigs delivered by cesarean-section at 10 d preterm and near full term (115 d gestation) were fitted with orogastric and umbilical arterial catheters. Pigs were f...
#2Yan HuiH-Index: 1
Last. Stine B. BeringH-Index: 14
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Human milk is rich in nutritional factors, such as alpha-lactalbumin (α-Lac), and important for neonatal development, but nutrient supplementation may be required for optimal growth. Using a pig model, we hypothesized that α-Lac-enriched whey protein concentrate (WPC) supplementation improves neonatal development. Cesarean-delivered preterm pigs were fed either dilute bovine milk (REF) or REF milk supplemented with WPC with normal (STANDARD-ALPHA) or high (HIGH-ALPHA) α-Lac. Clinical, gut, immun...
#1Kristine Bach Korsholm Knudsen (UCPH: University of Copenhagen)H-Index: 1
#2Jorgen Thorup (UCPH: University of Copenhagen)H-Index: 17
Last. Inge Bøtker Rasmussen Ifaoui (Copenhagen University Hospital)H-Index: 2
view all 11 authors...
Aim of the Study: Necrotizing enterocolitis (NEC) is a devastating intestinal disease that mainly affects preterm infants. Despite advancements in neonatal care, mortality of NEC remains high and c...