Marcel A. Behr
McGill University
Publications 232
#1Marcel A. Behr (McGill University)H-Index: 52
#2Paul H. Edelstein (UPenn: University of Pennsylvania)H-Index: 48
Last.Lalita Ramakrishnan (LMB: Laboratory of Molecular Biology)H-Index: 43
view all 3 authors...
People with immunoreactivity to tuberculosis are thought to have lifelong asymptomatic infection and remain at risk for active tuberculosis. Marcel A Behr and colleagues argue that most of these people are no longer infected
#1Robyn S. Lee (Harvard University)H-Index: 8
Last.Bill Hanage (Harvard University)H-Index: 1
view all 5 authors...
Background: Tuberculosis disproportionately affects the Canadian Inuit population. To address this problem, it is imperative we understand transmission dynamics. Here, we investigate whether 9deep9 sequencing provides additional resolution compared to standard sequencing, with implications for TB control in high-transmission environments. Methods: 48/50 samples from an outbreak (2011-2012), and 14/15 samples from the preceding five years from an Arctic village, were deep sequenced (to ~500-1000x...
#1Jeffrey Buter (Brigham and Women's Hospital)H-Index: 7
#2Tan-Yun Cheng (Brigham and Women's Hospital)H-Index: 24
Last.D. Branch Moody (Brigham and Women's Hospital)H-Index: 47
view all 30 authors...
Mycobacterium tuberculosis (Mtb) is the world’s most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an unusual terpene nucleoside of unknown function. In the present study 1-TbAd has been shown to be a naturally evolved phagolysosome disruptor. 1-TbAd is highly prevalent among patient-derived Mtb strains, where it is among the most abundant lipids produced. Synthesis of TbAd analogs and their testing in cells demonstrate that their biological...
2 CitationsSource
#1Jean-Yves Dubé (McGill University)
#2Fiona McIntosh (McGill University)H-Index: 14
Last.Marcel A. BehrH-Index: 52
view all 6 authors...
Complete Freund9s adjuvant (CFA) has historically been one of the most useful tools of immunologists. Essentially comprised of dead mycobacteria and mineral oil, we asked ourselves what is special about the mycobacterial part of this adjuvant, and could it be recapitulated synthetically? Here, we demonstrate the essentiality of N-glycolylated peptidoglycan plus trehalose dimycolate (both unique in mycobacteria) for the complete adjuvant effect using knockouts and chemical complementation. A comb...
#1Mariam El-Zein (McGill University)H-Index: 10
#2Sheila Bouten (McGill University)H-Index: 2
Last.Eduardo L. Franco (McGill University)H-Index: 81
view all 8 authors...
Background: Self-sampling has become an attractive proposition now that human papillomavirus (HPV) primary testing is being incorporated into cervical cancer screening programs worldwide. We compared predictive values of HPV testing based on self- and physician-collected samples, and cytology, in detecting high-grade cervical intraepithelial neoplasia (CIN). Methods: The Cervical And Self-Sample In Screening (CASSIS) study enrolled 1,217 women ages 16–70 years prior to scheduled colposcopies. Va...
#1Matthew P. Cheng (Harvard University)H-Index: 10
#2Guillame Butler-Laporte (McGill University)
Last.Marcel A. Behr (McGill University)H-Index: 52
view all 6 authors...
#1Sarah F. Ackley (UCSF: University of California, San Francisco)H-Index: 7
#2Robyn S. Lee (Harvard University)H-Index: 8
Last.Caitlin S. Pepperell (UW: University of Wisconsin-Madison)H-Index: 13
view all 7 authors...
A recent study reported on a tuberculosis (TB) outbreak in a largely Inuit village. Among newly infected individuals, exposure to additional active cases was associated with an increasing probabili...
#1Daniela Brites (University of Basel)H-Index: 9
#2Chloé Loiseau (University of Basel)H-Index: 5
Last.Sebastien Gagneux (University of Basel)H-Index: 56
view all 13 authors...
Tuberculosis (TB) affects humans and other animals and is caused by bacteria from the Mycobacterium tuberculosis complex (MTBC). Previous studies have shown that there are at least nine members of the MTBC infecting animals other than humans; these have also been referred to as ecotypes. However, the ecology and the evolution of these animal-adapted MTBC ecotypes are poorly understood. Here we screened 12,886 publicly available MTBC genomes and newly sequenced 17 animal-adapted MTBC strains, gat...
9 CitationsSource
#1Marcel A. Behr (MUHC: McGill University Health Centre)H-Index: 52
#2Paul H. Edelstein (UPenn: University of Pennsylvania)H-Index: 48
Last.Lalita Ramakrishnan (LMB: Laboratory of Molecular Biology)H-Index: 43
view all 3 authors...
Tuberculosis has a much shorter incubation period than is widely thought, say Marcel A Behr and colleagues , and this has implications for prioritising research and public health strategies
42 CitationsSource
#1Violet N. ChihotaH-Index: 15
#2Antoinette NiehausH-Index: 1
Last.Robin M. WarrenH-Index: 60
view all 17 authors...
8 CitationsSource