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Gerald Schatten
University of Pittsburgh
301Publications
71H-index
16.3kCitations
Publications 301
Newest
Published on May 1, 2019in European Journal of Medical Genetics2.02
Joyce C. Harper46
Estimated H-index: 46
(UCL: University College London),
Gerald Schatten71
Estimated H-index: 71
(University of Pittsburgh)
Abstract Perhaps the two most significant pioneering biomedical discoveries with immediate clinical implications during the past forty years have been the advent of assisted reproductive technologies (ART) and the genetics revolution. ART, including in vitro fertilization (IVF), intracytoplasmic sperm injection and preimplantation genetic testing, has resulted in the birth of more than 8 million children, and the pioneer of IVF, Professor Bob Edwards, was awarded the 2010 Nobel Prize. The geneti...
Published on Dec 1, 2018in Nature Communications11.88
Emily L. Fishman3
Estimated H-index: 3
(UT: University of Toledo),
Kyoung Jo4
Estimated H-index: 4
(UT: University of Toledo)
+ 10 AuthorsGerald Schatten71
Estimated H-index: 71
(University of Pittsburgh)
In the original version of this Article, the affiliation details for Jadranka Loncarek and Vito Mennella were incorrectly given as ‘Cell Biology Program, The Hospital for Sick Children, Department of Biochemistry, University of Toronto, 555 University Avenue, Toronto, ON, M5G 1X8, Canada’ and ‘Laboratory of Protein Dynamics and Signaling, Center for Cancer Research, National Cancer Institute, 1050 Boyles Street, Frederick, MD, 21702, USA’, respectively. This has now been corrected in both the PD...
Published on Dec 1, 2018in Nature Communications11.88
Emily L. Fishman3
Estimated H-index: 3
(UT: University of Toledo),
Kyoung Jo4
Estimated H-index: 4
(UT: University of Toledo)
+ 10 AuthorsGerald Schatten71
Estimated H-index: 71
(University of Pittsburgh)
The inheritance of the centrosome during human fertilization remains mysterious. Here we show that the sperm centrosome contains, in addition to the known typical barrel-shaped centriole (the proximal centriole, PC), a surrounding matrix (pericentriolar material, PCM), and an atypical centriole (distal centriole, DC) composed of splayed microtubules surrounding previously undescribed rods of centriole luminal proteins. The sperm centrosome is remodeled by both reduction and enrichment of specifi...
Published on Dec 1, 2018in Scientific Reports4.01
Calvin Simerly31
Estimated H-index: 31
(University of Pittsburgh),
Marion Manil-Ségalen1
Estimated H-index: 1
(PSL Research University)
+ 5 AuthorsGerald Schatten71
Estimated H-index: 71
(University of Pittsburgh)
Oocytes, including from mammals, lack centrioles, but neither the mechanism by which mature eggs lose their centrioles nor the exact stage at which centrioles are destroyed during oogenesis is known. To answer questions raised by centriole disappearance during oogenesis, using a transgenic mouse expressing GFP-centrin-2 (GFP CETN2), we traced their presence from e11.5 primordial germ cells (PGCs) through oogenesis and their ultimate dissolution in mature oocytes. We show tightly coupled CETN2 do...
Published on Oct 1, 2016in Scientific Reports4.01
Calvin Simerly31
Estimated H-index: 31
,
Carlos A. Castro15
Estimated H-index: 15
+ 4 AuthorsGerald Schatten71
Estimated H-index: 71
Post-Testicular Sperm Maturation: Centriole Pairs, Found in Upper Epididymis, are Destroyed Prior to Sperm’s Release at Ejaculation
Published on Dec 1, 2015in Current Biology9.19
Gerald Schatten71
Estimated H-index: 71
(University of Pittsburgh),
Tim Stearns55
Estimated H-index: 55
(Stanford University)
Summary Centrosomes are reduced to their cores in sperm. Emerging molecular explanations for centrosome construction have now helped to elucidate the mechanism of their destruction in sperm. Since centrosome inaccuracies cause aneuploidies responsible for cancers, birth defects and infertility, this new insight into centrosome behavior has broad implications.
Published on Aug 6, 2015in EMBO Reports8.38
Gerald Schatten71
Estimated H-index: 71
(University of Pittsburgh),
Calvin Simerly31
Estimated H-index: 31
(University of Pittsburgh)
Centriole construction, now revealed by crystallography, proteomics, and imaging to be a sophisticated assembly of interlocking bricks, resembles LEGOs—albeit centrioles have remarkable dynamic capabilities, including self‐assembly and dis‐assembly, kinases and post‐translational modifications, self‐replication, and still mysterious mechanisms for transmission through each cell cycle and via the gametes during development. Centrioles are created by core proteins that aggregate to form unique nin...
Published on Jan 1, 2015
Gerald Schatten71
Estimated H-index: 71
,
Tim Stearns55
Estimated H-index: 55
Centrosomes are reduced to their cores in sperm. Emerging molecular explanations for centrosomeconstruction have now helped to elucidate the mechanism of their destruction in sperm. Sincecentrosome inaccuracies cause aneuploidies responsible for cancers, birth defects and infertility, this newinsight into centrosome behavior has broad implications.
Published on Jan 1, 2015in Reproduction, Fertility and Development1.72
Charles A. Easley13
Estimated H-index: 13
(Emory University),
Calvin Simerly31
Estimated H-index: 31
(University of Pittsburgh),
Gerald Schatten71
Estimated H-index: 71
(University of Pittsburgh)
Generating gametes from pluripotent stem cells (PSCs) has many scientific justifications and several biomedical rationales. Here, we consider several strategies for deriving gametes from PSCs from mice and primates (human and non-human) and their anticipated strengths, challenges and limitations. Although the ‘Weismann barrier’, which separates the mortal somatic cell lineages from the potentially immortal germline, has long existed, breakthroughs first in mice and now in humans are artificially...
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