Hans F. A. Vasen
Leiden University
CancerLynch syndromeFamilial adenomatous polyposisColorectal cancerMedicine
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Publications 502
#1Ceranza G. Daans (VUmc: VU University Medical Center)
#2Zeinab Ghorbanoghli (LUMC: Leiden University Medical Center)H-Index: 3
Last. Jurjen J. Boonstra (LUMC: Leiden University Medical Center)H-Index: 1
view all 9 authors...
Barrett’s oesophagus (BE) has been associated with an increased risk of both colorectal adenomas and colorectal cancer. A recent investigation reported a high frequency of BE in patients with adenomatous polyposis coli (APC)-associated polyposis (FAP). The aim of the present study is to evaluate the prevalence of BE in a large cohort of patients with MUTYH-associated polyposis (MAP) and APC-associated adenomatous polyposis. Patients with a genetically confirmed diagnosis of familial adenomatous ...
#1Diantha Terlouw (LUMC: Leiden University Medical Center)
#2Manon Suerink (LUMC: Leiden University Medical Center)H-Index: 5
Last. Maartje Nielsen (LUMC: Leiden University Medical Center)H-Index: 24
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This study aimed to determine the prevalence of APC-associated familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP) in a large cohort, taking into account factors as adenoma count and year of diagnosis. All application forms used to send patients in for APC and MUTYH variant analysis between 1992 and 2017 were collected (n = 2082). Using the data provided on the application form, the APC and biallelic MUTYH prevalence was determined and possible predictive factors were exami...
#1Christoph Engel (Leipzig University)H-Index: 57
#2Aysel Ahadova (DKFZ: German Cancer Research Center)H-Index: 5
Last. Hans F. A. Vasen (LEI: Leiden University)H-Index: 91
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Abstract Background & Aims Lynch syndrome is caused by variants in DNA mismatch repair (MMR) genes and associated with an increased risk of colorectal cancer (CRC). In patients with Lynch syndrome, CRCs can develop via different pathways. We studied associations between Lynch syndrome-associated variants in MMR genes and risks of adenoma and CRC and somatic mutations in APC and CTNNB1 in tumors in an international cohort of patients. Methods We combined clinical and molecular data from 3 studies...
#1Micheal Goggins (Johns Hopkins University)H-Index: 95
#2Kasper A. Overbeek (Erasmus University Medical Center)H-Index: 2
Last. Marco J. Bruno (EUR: Erasmus University Rotterdam)H-Index: 57
view all 26 authors...
Background and aim The International Cancer of the Pancreas Screening Consortium met in 2018 to update its consensus recommendations for the management of individuals with increased risk of pancreatic cancer based on family history or germline mutation status (high-risk individuals). Methods A modified Delphi approach was employed to reach consensus among a multidisciplinary group of experts who voted on consensus statements. Consensus was considered reached if ≥75% agreed or disagreed. Results ...
1 CitationsSource
#1Elizabeth PageH-Index: 9
#2Elizabeth BancroftH-Index: 19
Last. Rosalind A. EelesH-Index: 93
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Abstract Background Mutations in BRCA2 cause a higher risk of early-onset aggressive prostate cancer (PrCa). The IMPACT study is evaluating targeted PrCa screening using prostate-specific-antigen (PSA) in men with germline BRCA1/2 mutations. Objective To report the utility of PSA screening, PrCa incidence, positive predictive value of PSA, biopsy, and tumour characteristics after 3 yr of screening, by BRCA status. Design, setting, and participants Men aged 40–69 yr with a germline pathogenic BRC...
4 CitationsSource
#1Toni Seppälä (UH: University of Helsinki)H-Index: 7
#2Aysel Ahadova (Heidelberg University)H-Index: 1
Last. Pål Møller (Witten/Herdecke University)H-Index: 39
view all 57 authors...
Recent epidemiological evidence shows that colorectal cancer (CRC) continues to occur in carriers of pathogenic mismatch repair (path_MMR) variants despite frequent colonoscopy surveillance in expert centres. This observation conflicts with the paradigm that removal of all visible polyps should prevent the vast majority of CRC in path_MMR carriers, provided the screening interval is sufficiently short and colonoscopic practice is optimal. To inform the debate, we examined, in the Prospective Lyn...
2 CitationsSource
#1Jasmijn F. Haanstra (UMCG: University Medical Center Groningen)H-Index: 4
#2Evelien Dekker (UvA: University of Amsterdam)H-Index: 51
Last. Jan J. Koornstra (UMCG: University Medical Center Groningen)H-Index: 22
view all 10 authors...
Background and Aims Patients with Lynch syndrome (LS) undergo regular surveillance by colonoscopy because of an increased risk of colorectal neoplasia, particularly in the proximal colon. Chromoendoscopy (CE) has been reported to improve neoplasia detection compared with conventional white-light endoscopy (WLE), but evidence is limited. Our aim was to investigate the effect of CE in the proximal colon on detection of neoplastic lesions during surveillance in LS. Methods This was a multicenter pr...
2 CitationsSource
#1A.B. Halk (LUMC: Leiden University Medical Center)
#2Thomas P. Potjer (LUMC: Leiden University Medical Center)H-Index: 7
Last. R. van Doorn (LUMC: Leiden University Medical Center)H-Index: 4
view all 6 authors...
#1Inge M. M. LakemanH-Index: 1
#2Florentine S Hilbers (Breast International Group)H-Index: 1
Last. Peter DevileeH-Index: 88
view all 14 authors...
Background The currently known breast cancer-associated single nucleotide polymorphisms (SNPs) are presently not used to guide clinical management. We explored whether a genetic test that incorporates a SNP-based polygenic risk score (PRS) is clinically meaningful in non-BRCA1/2 high-risk breast cancer families. Methods 101 non-BRCA1/2 high-risk breast cancer families were included; 323 cases and 262 unaffected female relatives were genotyped. The 161-SNP PRS was calculated and standardised to 3...
1 CitationsSource
#1Hans F. A. Vasen (LUMC: Leiden University Medical Center)H-Index: 91
#2Detlef K. BartschH-Index: 45
Last. Alfredo CarratoH-Index: 48
view all 3 authors...