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MoritaHiroshi
CardiologyChemistryBrugada syndromeDiabetes mellitusMedicine
789Publications
53H-index
10.7kCitations
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Publications 448
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#1Akio Shimizu (Shiga University of Medical Science)H-Index: 5
#1Akio Shimizu (Shiga University of Medical Science)H-Index: 15
Last. Yoshihiro Asano (Osaka University)H-Index: 22
view all 20 authors...
Brugada syndrome (BrS) is an inherited channelopathy responsible for almost 20% of sudden cardiac deaths in patients with nonstructural cardiac diseases. Approximately 70% of BrS patients, the causative gene mutation(s) remains unknown. In this study, we used whole exome sequencing to investigate candidate mutations in a family clinically diagnosed with BrS. A heterozygous 1616G>A substitution (R539Q mutation) was identified in the transmembrane protein 168 (TMEM168) gene of symptomatic individu...
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#1Saori Asada (Okayama University)
#2MoritaHiroshi (Okayama University)H-Index: 53
Last. Hiroshi Ito (Okayama University)H-Index: 51
view all 10 authors...
AIMS: To establish the indication for programmed ventricular stimulation (PVS) for asymptomatic patients with Brugada syndrome (BrS), we evaluated the prognostic significance of PVS based on abnormal electrocardiogram (ECG) markers. METHODS AND RESULTS: One hundred and twenty-five asymptomatic patients with BrS were included. We performed PVS at two sites of the right ventricle with up to three extrastimuli [two pacing cycle lengths and minimum coupling interval (MCI) of 180 ms]. We followed the...
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#1Hironobu Toda (Okayama University)H-Index: 2
#2K. Nakamura (Okayama University)H-Index: 44
Last. Nobuhiro Nishii (Okayama University)H-Index: 23
view all 15 authors...
BACKGROUND: The aim of this study was to evaluate the efficacy and safety of transdermal beta-blocker patches, which offer stable blood concentration and easy availability during operation, for prevention of perioperative myocardial injury (PMI) in high-risk patients.Methods and Results:In this randomized controlled trial, patients aged >60 years with hypertension and high revised cardiac risk index (>/=2) undergoing non-cardiac surgery were randomly assigned to a bisoprolol patch or control gro...
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#1Akihito Miyoshi (Okayama University)H-Index: 3
#2Nobuhiro Nishii (Okayama University)H-Index: 23
Last. Hiroshi Ito (Okayama University)H-Index: 51
view all 10 authors...
BACKGROUND: In heart failure (HF) patients implanted with high-energy devices, worsening of HF can be diagnosed from intrathoracic impedance (ITI) before symptoms appear. Early therapeutic intervention can prevent HF worsening, but the optimal intervention remains unknown. This study aimed to examine which lifestyle modifications or medications can improve HF indicators in asymptomatic HF patients diagnosed from ITI.Methods and Results:This multicenter, prospective, randomized study included pat...
1 CitationsSource
#1Soichiro Ogura (Okayama University)
#2K. Nakamura (Okayama University)H-Index: 44
Last. Hiroshi Ito (Okayama University)H-Index: 51
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BACKGROUND: Multiple spikes in the QRS complex (fragmented QRS [fQRS]) on 12-lead electrocardiography have been associated with ventricular arrhythmic events (VAEs) in patients with hypertrophic cardiomyopathy (HCM). The aim of this study was to assess the association between new appearances of fQRS and cardiac events in patients with HCM.Methods and Results:The association between baseline fQRS and cardiac events, namely VAEs, heart failure-related hospitalization, and all-cause death, was eval...
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#1Tsukasa KamakuraH-Index: 9
#2Tetsuji Shinohara (Oita University)H-Index: 20
Last. Kengo KusanoH-Index: 29
view all 12 authors...
Objective Limited data are currently available regarding the long-term prognosis of patients with J-wave syndrome (JWS). The aim of this study was to investigate the long-term prognosis of patients with JWS and identify predictors of the recurrence of ventricular fibrillation (VF). Methods This was a multicentre retrospective study (seven Japanese hospitals) involving 134 patients with JWS (Brugada syndrome (BrS): 85; early repolarisation syndrome (ERS): 49) treated with an implantable cardiover...
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#1Masahiro Hosonuma (Showa University)
#2Nobuyuki Yajima (Kyoto University)H-Index: 14
Last. MoritaHiroshi (Okayama University)H-Index: 53
view all 9 authors...
Objective Cardiovascular disease is an important contributor to the mortality rate of patients with systemic lupus erythematosus (SLE), which is related to SLE disease activity. Fragmented QRS (fQRS) complexes, defined by additional spikes in the QRS complex, are useful for identifying myocardial scars on electrocardiography and can be an independent predictor of cardiac events. We aimed to assess the relationship between disease activity in patients with SLE and fQRS at the time of diagnosis. M...
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#1Koji Nakagawa (Okayama University)H-Index: 9
#2Teiji Akagi (Okayama University)H-Index: 6
Last. Hiroshi Ito (Okayama University)H-Index: 53
view all 12 authors...
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#1Takashi Miki (Okayama University)H-Index: 4
#2Toru Miyoshi (Okayama University)H-Index: 26
Last. Hiroshi Ito (Okayama University)H-Index: 53
view all 9 authors...
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