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Gessynger Morais-Silva
Federal University of São Carlos
EndocrinologyPsychologyEthanolDiabetes mellitusPharmacology
15Publications
4H-index
39Citations
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Publications 15
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AbstractMaternal separation (MS) is an animal model widely used to evaluate the influence of early-life stress exposure on ethanol consumption and dependence. The goal of this study was to evaluate...
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#1Willian Costa-Ferreira (UFSCar: Federal University of São Carlos)H-Index: 3
#2Gessynger Morais-Silva (UFSCar: Federal University of São Carlos)H-Index: 4
Last. Carlos C. Crestani (UFSCar: Federal University of São Carlos)H-Index: 20
view all 5 authors...
The present study investigated the effect of the treatment with the angiotensin II type 1 receptor (AT1) antagonist losartan in the depressive-like state and memory impairment evoked by exposure to either homotypic (i.e., repeated exposure to the same type of stressor) or heterotypic (i.e., exposure to different aversive stimuli) chronic stressors in rats. For this, male Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable str...
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#1Gessynger Morais-Silva (UFSCar: Federal University of São Carlos)H-Index: 4
#2Willian Costa-Ferreira (UFSCar: Federal University of São Carlos)H-Index: 3
Last. Marcelo Tadeu Marin (UFSCar: Federal University of São Carlos)H-Index: 12
view all 6 authors...
Abstract Stress exposure is an important risk factor for psychiatric and cardiovascular disorders. Two phenotypes related to coping with stress can be observed in rodents that experience chronic social defeat stress (SDS): susceptible, showing social avoidance and behavioral changes related to depression, and resilient, showing none of these alterations. Moreover, a strong correlation exists between depression and the development of or mortality due to cardiovascular diseases. Nevertheless, litt...
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#1Jonas O. Vieira (UFSCar: Federal University of São Carlos)H-Index: 2
#2Josiane O. Duarte (UFSCar: Federal University of São Carlos)H-Index: 6
Last. Carlos C. Crestani (UFSCar: Federal University of São Carlos)H-Index: 20
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Abstract This study investigated the physiological, somatic and behavioral changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in male and female rats. For this, adult Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor). Effects evoked by CVS included: (i) adrenal hypertrophy and decreased body weight gain in male ani...
18 CitationsSource
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Sao Paulo State Univ UNESP, Sch Pharmaceut Sci Araraquara, Pharmacol Lab, Araraquara, Brazil
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Introducao: Segundo a organizacao mundial de saude, o etanol e a substância psicoativa que causa dependencia mais consumida no mundo, sendo esse um grave problema de saude publica. Frequentemente alcoolistas tentam abster-se do consumo de etanol, mas por algum motivo acabam recaindo ao uso da substância. O estado de ansiedade e relatado como um importante fator que leva ao consumo de etanol. Alem disso, a exposicao ao estresse e conhecida como um importante indutor tanto do aumento da ansiedade ...
#1Marcelo Tadeu Marin (UNESP: Sao Paulo State University)H-Index: 12
#2Gessynger Morais-Silva (UNESP: Sao Paulo State University)H-Index: 4
Ethanol is the most popular addictive substance used in the word. Its small and relatively simple structure facilitates its access to brain tissues and binding to many sites. This relatively unspecific action can partially explain the myriad of effects and also the dose-dependent actions of this drug. This chapter highlights ethanol action mechanisms from the early classical studies, showing ethanol effects on lipid neuronal membranes, to recent studies, showing specific binding to many protein ...
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#1Gessynger Morais-Silva (UFSCar: Federal University of São Carlos)H-Index: 4
#2Gabrielle Cunha Alves (UNESP: Sao Paulo State University)H-Index: 1
Last. Marcelo Tadeu Marin (UFSCar: Federal University of São Carlos)H-Index: 12
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Ethanol addiction is a serious public health problem that still needs more effective pharmacological treatment. A key factor in the development and maintenance of this disease is the advent of neuroadaptations in the mesocorticolimbic brain pathway upon chronic ethanol abuse. In general, these neuroadaptations are maladaptive and affect numerous neurotransmitter systems and intracellular molecules. One of these molecules is ΔFosB, a transcription factor that is altered after chronic drug use. Be...
7 CitationsSource
Introducao: Todas as substâncias psicoativas que causam dependencia, como o etanol, tem seu efeito modu- lado de forma importante pelo ambiente no qual sao administradas. A analise comportamental de animais de laboratorio, como camundongos, em resposta a drogas depende tambem do ambiente onde o efeito e mensu- rado. Uma das caracteristicas importantes do ambiente de teste e a transparencia de suas paredes, que pode permitir ao animal observar os arredores e tambem deixar entrar muita luz, a qual...
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