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Gessynger Morais-Silva
Federal University of São Carlos
14Publications
4H-index
29Citations
Publications 14
Newest
Published on Nov 1, 2019in Neurobiology of Stress
Gessynger Morais-Silva4
Estimated H-index: 4
(UFSCar: Federal University of São Carlos),
Willian Costa-Ferreira3
Estimated H-index: 3
(UFSCar: Federal University of São Carlos)
+ 3 AuthorsMarcelo Tadeu Marin11
Estimated H-index: 11
(UFSCar: Federal University of São Carlos)
Abstract Stress exposure is an important risk factor for psychiatric and cardiovascular disorders. Two phenotypes related to coping with stress can be observed in rodents that experience chronic social defeat stress (SDS): susceptible, showing social avoidance and behavioral changes related to depression, and resilient, showing none of these alterations. Moreover, a strong correlation exists between depression and the development of or mortality due to cardiovascular diseases. Nevertheless, litt...
AbstractMaternal separation (MS) is an animal model widely used to evaluate the influence of early-life stress exposure on ethanol consumption and dependence. The goal of this study was to evaluate...
Jonas O. Vieira2
Estimated H-index: 2
(UFSCar: Federal University of São Carlos),
Josiane O. Duarte5
Estimated H-index: 5
(UFSCar: Federal University of São Carlos)
+ 3 AuthorsCarlos C. Crestani19
Estimated H-index: 19
(UFSCar: Federal University of São Carlos)
Abstract This study investigated the physiological, somatic and behavioral changes evoked by daily exposure to the same type of stressor (homotypic) or different aversive stressor stimuli (heterotypic) in male and female rats. For this, adult Wistar rats were subjected to a 10 days regimen of repeated restraint stress (RRS, homotypic stressor) or chronic variable stress (CVS, heterotypic stressor). Effects evoked by CVS included: (i) adrenal hypertrophy and decreased body weight gain in male ani...
Published on Oct 1, 2017in European Neuropsychopharmacology4.47
Gessynger Morais-Silva4
Estimated H-index: 4
,
Willian Costa-Ferreira3
Estimated H-index: 3
+ 3 AuthorsMarcelo Tadeu Marin11
Estimated H-index: 11
Sao Paulo State Univ UNESP, Sch Pharmaceut Sci Araraquara, Pharmacol Lab, Araraquara, Brazil
Introducao: Segundo a organizacao mundial de saude, o etanol e a substância psicoativa que causa dependencia mais consumida no mundo, sendo esse um grave problema de saude publica. Frequentemente alcoolistas tentam abster-se do consumo de etanol, mas por algum motivo acabam recaindo ao uso da substância. O estado de ansiedade e relatado como um importante fator que leva ao consumo de etanol. Alem disso, a exposicao ao estresse e conhecida como um importante indutor tanto do aumento da ansiedade ...
Published on Jan 1, 2017
M.T. Marin (UNESP: Sao Paulo State University), G. Morais-Silva (UNESP: Sao Paulo State University)
Ethanol is the most popular addictive substance used in the word. Its small and relatively simple structure facilitates its access to brain tissues and binding to many sites. This relatively unspecific action can partially explain the myriad of effects and also the dose-dependent actions of this drug. This chapter highlights ethanol action mechanisms from the early classical studies, showing ethanol effects on lipid neuronal membranes, to recent studies, showing specific binding to many protein ...
Published on Nov 1, 2016in Neuropharmacology4.37
Gessynger Morais-Silva4
Estimated H-index: 4
(UFSCar: Federal University of São Carlos),
Gabrielle Cunha Alves1
Estimated H-index: 1
(UNESP: Sao Paulo State University),
Marcelo Tadeu Marin11
Estimated H-index: 11
(UFSCar: Federal University of São Carlos)
Ethanol addiction is a serious public health problem that still needs more effective pharmacological treatment. A key factor in the development and maintenance of this disease is the advent of neuroadaptations in the mesocorticolimbic brain pathway upon chronic ethanol abuse. In general, these neuroadaptations are maladaptive and affect numerous neurotransmitter systems and intracellular molecules. One of these molecules is ΔFosB, a transcription factor that is altered after chronic drug use. Be...
Introducao: Segundo a organizacao mundial de saude, o etanol e a substância psicoativa que causa dependencia mais consumida no mundo, sendo esse um grave problema de saude publica. Frequentemente alcoolistas tentam se abster do consumo de etanol, mas por algum motivo acabam recaindo ao uso da substância. Estimulos estressantes sao grandes indutores de recaida quando o individuo esta no periodo de abstinencia. Por isto e importante determinar as alteracoes comportamentais relacionadas a esse peri...
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