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Elizabeth A. Platz
Johns Hopkins University
500Publications
81H-index
20.4kCitations
Publications 502
Newest
#1Yuhan Huang (Johns Hopkins University)
#2Dominique S. Michaud (Tufts University)H-Index: 59
Last.Elizabeth A. Platz (Johns Hopkins University)H-Index: 81
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Purpose We evaluated the association between clinically assessed periodontal disease and serum prostate-specific antigen (PSA) concentration in men without a prostate cancer diagnosis in a US nationally representative sample of non-institutionalized men.
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Abstract Background & Aims Early-onset colorectal cancer (CRC, in persons younger than 50 years old) is increasing in incidence; yet, in the absence of a family history of CRC, this population lacks harmonized recommendations for prevention. We aimed to determine whether a polygenic risk score (PRS) developed from 95 CRC-associated common genetic risk variants was associated with risk for early-onset CRC. Methods We studied risk for CRC associated with a weighted PRS in 12,197 participants young...
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Purpose:Statins are associated with lower risk of aggressive prostate cancer, but lethal prostate cancer is understudied and contributing mechanisms unclear. We prospectively examined statins and lethal prostate cancer risk in the Health Professionals Follow-up Study (HPFS), tested associations with molecular subtypes, and integrated gene expression profiling to identify putative mechanisms. Experimental Design:Our study included 44,126 men cancer-free in 1990, followed for prostate cancer incid...
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#1Jiayun Lu (Johns Hopkins University)H-Index: 2
#2Ina Zaimi (Tufts University)H-Index: 1
Last.Dominique S. Michaud (Tufts University)H-Index: 59
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Abstract Purpose Severe periodontal disease and edentulism have been previously reported to be significantly associated with cancer risk and mortality, including in the Atherosclerosis Risk in Communities study (2018); however, complex sources of confounding by socioeconomic status (SES), and characteristics correlated with SES, could have been present in earlier analyses. Methods To capture life course SES and its correlates, we generated a propensity score and included it, along with other pot...
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#1Susan Chadid (Johns Hopkins University)
#2John R. Barber (Johns Hopkins University)H-Index: 8
Last.Elizabeth A. Platz (Johns Hopkins University)H-Index: 81
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#1Marvin E. Langston (WashU: Washington University in St. Louis)H-Index: 4
#2Ankita Bhalla (UCSF: University of California, San Francisco)
Last.Siobhan Sutcliffe (WashU: Washington University in St. Louis)H-Index: 26
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#1Elizabeth A. Platz (Johns Hopkins University)H-Index: 81
#2John R. Barber (Johns Hopkins University)H-Index: 8
Last.Sabine Rohrmann (UZH: University of Zurich)H-Index: 62
view all 10 authors...
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#1Yiwen Zhang (Harvard University)
#2Cindy Ke Zhou (Harvard University)H-Index: 1
Last.Ericka M. Ebot (Harvard University)H-Index: 5
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Background: Inflammation and focal atrophy are common features adjacent to prostate tumors. Limited evidence exists on whether these features have prognostic significance. Methods: In the Health Professionals Follow-Up Study and Physicians9 Health Study, we studied 1,035 men diagnosed with prostate cancer. A genitourinary pathologist centrally reviewed tumor and normal areas of hematoxylin and eosin slides from prostate cancer specimens for the presence of acute and chronic inflammation, and fou...
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#1David D Celentano (Johns Hopkins University)H-Index: 77
#2Elizabeth A. Platz (Johns Hopkins University)H-Index: 81
Last.Hemali Mehta (Johns Hopkins University)H-Index: 54
view all 3 authors...
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#1Nikos Papadimitriou (IARC: International Agency for Research on Cancer)H-Index: 3
#2Niki Dimou (IARC: International Agency for Research on Cancer)H-Index: 2
Last.Neil Murphy (IARC: International Agency for Research on Cancer)H-Index: 24
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Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomization analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.59, 95% confidence interval [CI]: 0.42 to 0.84, P-value=0....
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