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Josué L. Castro-Mejía
University of Copenhagen
28Publications
7H-index
131Citations
Publications 28
Newest
#1Aviaja L Hauptmann (University of Greenland)
#2Petronela Paulová (UCPH: University of Copenhagen)
Last.Dennis Sandris Nielsen (UCPH: University of Copenhagen)H-Index: 36
view all 7 authors...
Abstract The practices of preparing traditional foods in the Arctic are rapidly disappearing. Traditional foods of the Arctic represent a rarity among food studies in that they are meat-sourced and prepared in non-industrial settings. These foods, generally consumed without any heating step prior to consumption, harbor an insofar undescribed microbiome. The food-associated microbiomes have implications not only with respect to disease risk, but might also positively influence host health by tran...
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#1Łukasz Krych (UCPH: University of Copenhagen)H-Index: 10
#2Josué L. Castro-Mejía (UCPH: University of Copenhagen)H-Index: 7
Last.Dennis Sandris Nielsen (UCPH: University of Copenhagen)H-Index: 36
view all 8 authors...
Despite the massive developments within culture-independent methods for detection of microorganisms during the last decade, culture-based methods remain a cornerstone in microbiology. Yet, the problem of rapid, accurate and inexpensive identification of bacterial isolates down to species/strain level remains unresolved. We have developed a new method for bacterial DNA enrichment and tagmentation allowing fast ( 99%) consensus reads. Whereas, the information from high quality reads is used to ret...
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#1Josué L. Castro-Mejía (UCPH: University of Copenhagen)H-Index: 7
#2Bekzod Khakimov (UCPH: University of Copenhagen)H-Index: 12
Last.Dennis Sandris Nielsen (UCPH: University of Copenhagen)H-Index: 36
view all 22 authors...
When humans age, changes in body composition arise along with lifestyle-associated disorders influencing fitness and physical decline. Here we provide a comprehensive view of dietary intake, physical activity, gut microbiota (GM) and host metabolome in relation to physical fitness of 207 community dwelling subjects aged +65 years. Stratification on anthropometric/body-composition/physical-performance measurements (ABPm) variables identified two phenotypes (high/low-fitness) clearly linked to die...
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#1Torben Soelbeck Rasmussen (UCPH: University of Copenhagen)
#2Caroline M. Junker Mentzel (UCPH: University of Copenhagen)H-Index: 3
Last.Dennis Sandris Nielsen (UCPH: University of Copenhagen)H-Index: 36
view all 10 authors...
Objective: Development of obesity and type-2-diabetes (T2D) are associated with gut microbiota (GM) changes. The gut viral community is predominated by bacteriophages (phages), which are viruses that attack bacteria in a host-specific manner. As a proof-of-concept we demonstrate the efficacy of faecal virome transplantation (FVT) from lean donors for shifting the phenotype of obese mice into closer resemblance of lean mice. Design: The FVT consisted of viromes extracted from the caecal content o...
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#1Rasmus Riemer Jakobsen (UCPH: University of Copenhagen)H-Index: 1
#2Thor Haahr (AU: Aarhus University)H-Index: 8
Last.Dennis Sandris Nielsen (UCPH: University of Copenhagen)H-Index: 36
view all 9 authors...
Background: Bacterial vaginosis (BV) is characterised by a reduction in Lactobacillus spp. abundance and increased abundance of facultative anaerobes, like Gardnerella vaginalis. BV aetiology is not fully understood, but bacteriophages could play a pivotal role causing perturbation of the vaginal bacterial community. Here we investigate the vaginal viral community, including bacteriophages, and its association to the bacterial community and BV-status. Methods: Vaginal samples from 48 patients un...
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#2Kristina Kaasik (UCPH: University of Copenhagen)
Last.Dennis Sandris Nielsen (UCPH: University of Copenhagen)H-Index: 36
view all 12 authors...
Abstract Nicaraguan cocoa bean fermentations of several single local cocoa varieties originating from the same region (North Highlands of Nicaragua, San Jose de Bocay/El Cua) were compared to fermentations of blended cocoa varietals from other producing regions of the country (Waslala and Nueva Guinea) making use of High Throughput Sequencing techniques, metabolite target analysis and sensory evaluation of cocoa liquor samples. A succession of the important cocoa-related yeasts Hanseniaspora uva...
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#1Ling DengH-Index: 3
Last.Dennis Sandris NielsenH-Index: 36
view all 11 authors...
The human gut microbiome (GM) plays an important role in human health and diseases. However, while substantial progress has been made in understanding the role of bacterial inhabitants of the gut, much less is known regarding the viral component of the GM. Bacteriophages (phages) are viruses attacking specific host bacteria and likely play important roles in shaping the GM. Although metagenomic approaches have led to the discoveries of many new viruses, they remain largely uncultured as their ho...
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#1Hajar Fauzan Ahmad (Universiti Malaysia Pahang)H-Index: 5
#2Lars Schreiber (National Research Council)H-Index: 10
Last.Dennis Sandris Nielsen (UCPH: University of Copenhagen)H-Index: 36
view all 6 authors...
ABSTRACT Here, we present a 1.89-Mbp draft genome sequence of Streptococcus anginosus strain CALM001, a Gram-positive bacterium that was isolated from a fecal sample donated by a 70-year-old Dane enrolled in the Counteracting Age-Related Loss of Skeletal Muscle Mass (CALM) intervention study.
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#2Liv de VriesH-Index: 1
Last.Dennis Sandris NielsenH-Index: 36
view all 8 authors...
Often physiological studies using mice from one vendor show different outcome when being reproduced using mice from another vendor. These divergent phenotypes between similar mouse strains from different vendors have been assigned to differences in the gut microbiome. During recent years, evidence has mounted that the gut viral community plays a key role in shaping the gut microbiome and may thus also influence mouse phenotype. However, to date inter-vendor variation in the murine gut virome has...
2 CitationsSource
#1Torben Sølbeck Rasmussen (UCPH: University of Copenhagen)H-Index: 2
#2L. E. de Vries (UCPH: University of Copenhagen)H-Index: 2
Last.Dennis Sandris Nielsen (UCPH: University of Copenhagen)H-Index: 36
view all 8 authors...
Often physiological studies using mice from one vendor show different outcome when being reproduced using mice from another vendor. These divergent phenotypes between similar mouse strains from different vendors have been assigned to differences in the gut microbiome. During recent years, evidence has mounted that the gut viral community plays a key role in shaping the gut microbiome and may thus also influence mouse phenotype. However, to date inter-vendor variation in the murine gut virome has...
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