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Ian J. Deary
University of Edinburgh
1,855Publications
128H-index
67.8kCitations
Publications 1855
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#1Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
#2Lucia Ballerini (Edin.: University of Edinburgh)H-Index: 19
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 12 authors...
Abstract Introduction We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. Methods Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospati...
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#1Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
#2Lucia Ballerini (Edin.: University of Edinburgh)H-Index: 19
Last.Joanna M. Wardlaw (Edin.: University of Edinburgh)H-Index: 89
view all 15 authors...
Research has suggested that the retinal vasculature may act as a surrogate marker for diseased cerebral vessels. Retinal vascular parameters were measured using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE) software in two cohorts: (i) community-dwelling older subjects of the Lothian Birth Cohort 1936 (n = 603); and (ii) patients with recent minor ischaemic stroke of the Mild Stroke Study (n = 155). Imaging markers of small vessel disease (SVD) (white matter hyper...
2 CitationsSource
#1Yanni Zeng (Edin.: University of Edinburgh)H-Index: 6
#2Carmen Amador (Edin.: University of Edinburgh)H-Index: 7
Last.Chris Haley (Edin.: University of Edinburgh)H-Index: 59
view all 23 authors...
Parent-of-origin effects (POE) exist when there is differential expression of alleles inherited from the two parents. A genome-wide scan for POE on DNA methylation at 639,238 CpGs in 5,101 individuals identifies 733 independent methylation CpGs potentially influenced by POE at a false discovery rate ≤ 0.05 of which 331 had not previously been identified. Cis and trans methylation quantitative trait loci (mQTL) regulate methylation variation through POE at 54% (399/733) of the identified POE-infl...
3 CitationsSource
#1Jesper Lund (University of Southern Denmark)H-Index: 2
#2Shuxia Li (University of Southern Denmark)H-Index: 10
Last.Qihua Tan (University of Southern Denmark)H-Index: 32
view all 11 authors...
Background Multiple epigenome-wide association studies have been performed to identify DNA methylation patterns regulated by aging or correlated with risk of death. However, the inter-relatedness of the epigenetic basis of aging and mortality has not been well investigated.
3 CitationsSource
#1Fengchun Zhang (UQ: University of Queensland)H-Index: 13
#2Wenhan Chen (UQ: University of Queensland)H-Index: 2
Last.Jian Yang (WMU: Wenzhou Medical College)H-Index: 97
view all 11 authors...
The rapid increase of omic data has greatly facilitated the investigation of associations between omic profiles such as DNA methylation (DNAm) and complex traits in large cohorts. Here, we propose a mixed-linear-model-based method called MOMENT that tests for association between a DNAm probe and trait with all other distal probes fitted in multiple random-effect components to account for unobserved confounders. We demonstrate by simulations that MOMENT shows a lower false positive rate and more ...
4 CitationsSource
#1Catherine M. Calvin (University of Oxford)H-Index: 12
#2Saskia P. Hagenaars (Edin.: University of Edinburgh)H-Index: 21
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 8 authors...
Evidence suggests that lifestyle factors, e.g. physical activity, moderate the manifestation of genetic susceptibility to obesity. The present study uses UK Biobank data to investigate interaction between polygenic scores (PGS) for two obesity indicators, and lifestyle and psychosocial factors in the prediction of the two indicators, with attention to sex-specific effects. Analyses were of 112 151 participants (58 914 females; 40 to 73 years) whose genetic data passed quality control. Moderation...
1 CitationsSource
#1Philip J. Law (ICR: Institute of Cancer Research)H-Index: 12
#2Maria Timofeeva (Medical Research Council)H-Index: 10
Last.Malcolm G. Dunlop (Medical Research Council)H-Index: 66
view all 98 authors...
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene e...
4 CitationsSource
#1Gail Davies (Edin.: University of Edinburgh)H-Index: 52
#2Max LamH-Index: 10
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 222 authors...
Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
1 CitationsSource
#1Yanni Zeng (Edin.: University of Edinburgh)H-Index: 6
#2Carmen Amador (Edin.: University of Edinburgh)H-Index: 7
Last.Chris Haley (Edin.: University of Edinburgh)H-Index: 59
view all 23 authors...
In the original version of this Article, the legend in the upper panel of Figure 2 incorrectly read ‘paternal imprinting’ and should have read ‘maternal imprinting’. This has been corrected in both the PDF and HTML versions of the Article.
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#1Janie Corley (Edin.: University of Edinburgh)H-Index: 30
#2Simon R. Cox (Edin.: University of Edinburgh)H-Index: 20
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 10 authors...
Recent advances in genome-wide DNA methylation (DNAm) profiling for smoking behaviour have given rise to a new, molecular biomarker of smoking exposure. It is unclear whether a smoking-associated DNAm (epigenetic) score has predictive value for ageing-related health outcomes which is independent of contributions from self-reported (phenotypic) smoking measures. Blood DNA methylation levels were measured in 895 adults aged 70 years in the Lothian Birth Cohort 1936 (LBC1936) study using the Illumi...
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