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Ian J. Deary
University of Edinburgh
1,855Publications
128H-index
67.8kCitations
Publications 1892
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Abstract Fluctuating body asymmetry is theorized to indicate developmental instability, and to have small positive associations with low socioeconomic status (SES). Previous studies have reported small negative associations between fluctuating body asymmetry and cognitive functioning, but relationships between fluctuating brain asymmetry and cognitive functioning remain unclear. The present study investigated the association between general intelligence (a latent factor derived from a factor ana...
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Objectives We investigated the associations among blood pressure and cognitive functions across the eighth decade, while accounting for anti-hypertensive medication and lifetime stability in cognitive function. Design Prospective cohort study. Setting This study used data from the Lothian Birth Cohort 1936 (LBC1936) study, which recruited participants living in the Lothian region of Scotland when aged 70 years, most of whom had completed an intelligence test at age 11 years. Participants 1091 me...
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Using raw structural and diffusion brain MRI data from the UK Biobank (UKB; N = 3,155, ages 45-75 years) and the Lothian Birth Cohort 1936 (LBC1936; N = 534, all age 73 years), we examine aging of regional grey matter volumes (nodes) and white matter structural connectivity (edges) within networks-of-interest in the human brain connectome. In UKB, the magnitude of age-differences in individual node volumes and edge weights corresponds closely with their loadings on their respective principal com...
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People with higher levels of neuroticism seem to have drawn the short straw of personality. However, there are multiple ways to score highly in neuroticism. Analyses of the short scale of the Eysen...
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DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as...
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#1Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
#2Lucia Ballerini (Edin.: University of Edinburgh)H-Index: 19
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 128
view all 12 authors...
Abstract Introduction We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. Methods Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospati...
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#1Sarah McGrory (Edin.: University of Edinburgh)H-Index: 7
#2Lucia Ballerini (Edin.: University of Edinburgh)H-Index: 19
Last.Joanna M. Wardlaw (Edin.: University of Edinburgh)H-Index: 89
view all 15 authors...
Research has suggested that the retinal vasculature may act as a surrogate marker for diseased cerebral vessels. Retinal vascular parameters were measured using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE) software in two cohorts: (i) community-dwelling older subjects of the Lothian Birth Cohort 1936 (n = 603); and (ii) patients with recent minor ischaemic stroke of the Mild Stroke Study (n = 155). Imaging markers of small vessel disease (SVD) (white matter hyper...
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