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Ian J. Deary
University of Edinburgh
1,770Publications
121H-index
61.5kCitations
Publications 1770
Newest
Published in Scientific Reports 4.01
Sarah McGrory6
Estimated H-index: 6
(Edin.: University of Edinburgh),
Lucia Ballerini19
Estimated H-index: 19
(Edin.: University of Edinburgh)
+ -3 AuthorsBaljean Dhillon32
Estimated H-index: 32
(Edin.: University of Edinburgh)
Research has suggested that the retinal vasculature may act as a surrogate marker for diseased cerebral vessels. Retinal vascular parameters were measured using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE) software in two cohorts: (i) community-dwelling older subjects of the Lothian Birth Cohort 1936 (n = 603); and (ii) patients with recent minor ischaemic stroke of the Mild Stroke Study (n = 155). Imaging markers of small vessel disease (SVD) (white matter hyper...
Sarah McGrory6
Estimated H-index: 6
(Edin.: University of Edinburgh),
Lucia Ballerini19
Estimated H-index: 19
(Edin.: University of Edinburgh)
+ 9 AuthorsEmanuele Trucco32
Estimated H-index: 32
(Dund.: University of Dundee)
Abstract Introduction We test whether measures of the retinal vasculature are associated with cognitive functioning and cognitive change. Methods Retinal images from a narrow-age cohort were analyzed using Vessel Assessment and Measurement Platform for Images of the Retina, producing a comprehensive range of quantitative measurements of the retinal vasculature, at mean age 72.5 years (SD = 0.7). Cognitive ability and change were measured using a battery of multiple measures of memory, visuospati...
Published on Mar 27, 2019in Nature Communications 11.88
Yanni Zeng4
Estimated H-index: 4
(Edin.: University of Edinburgh),
Yanni Zeng2
Estimated H-index: 2
(Edin.: University of Edinburgh)
+ 20 AuthorsAndrew Bretherick4
Estimated H-index: 4
(Edin.: University of Edinburgh)
Parent-of-origin effects (POE) exist when there is differential expression of alleles inherited from the two parents. A genome-wide scan for POE on DNA methylation at 639,238 CpGs in 5,101 individuals identifies 733 independent methylation CpGs potentially influenced by POE at a false discovery rate ≤ 0.05 of which 331 had not previously been identified. Cis and trans methylation quantitative trait loci (mQTL) regulate methylation variation through POE at 54% (399/733) of the identified POE-infl...
Published on Jan 1, 2019in Clinical Epigenetics
Jesper Lund2
Estimated H-index: 2
,
Shuxia Li9
Estimated H-index: 9
(University of Southern Denmark)
+ 8 AuthorsRiccardo E. Marioni (Edin.: University of Edinburgh)
Background Multiple epigenome-wide association studies have been performed to identify DNA methylation patterns regulated by aging or correlated with risk of death. However, the inter-relatedness of the epigenetic basis of aging and mortality has not been well investigated.
Published on Dec 1, 2019in Genome Biology 14.03
Fengchun Zhang12
Estimated H-index: 12
(UQ: University of Queensland),
Wenhan Chen1
Estimated H-index: 1
(UQ: University of Queensland)
+ 8 AuthorsAllan F. McRae37
Estimated H-index: 37
(UQ: University of Queensland)
The rapid increase of omic data has greatly facilitated the investigation of associations between omic profiles such as DNA methylation (DNAm) and complex traits in large cohorts. Here, we propose a mixed-linear-model-based method called MOMENT that tests for association between a DNAm probe and trait with all other distal probes fitted in multiple random-effect components to account for unobserved confounders. We demonstrate by simulations that MOMENT shows a lower false positive rate and more ...
Published on Jan 23, 2019in Scientific Reports 4.01
Catherine M. Calvin11
Estimated H-index: 11
(University of Oxford),
Saskia P. Hagenaars18
Estimated H-index: 18
(Edin.: University of Edinburgh)
+ 5 AuthorsIan J. Deary121
Estimated H-index: 121
(Edin.: University of Edinburgh)
Evidence suggests that lifestyle factors, e.g. physical activity, moderate the manifestation of genetic susceptibility to obesity. The present study uses UK Biobank data to investigate interaction between polygenic scores (PGS) for two obesity indicators, and lifestyle and psychosocial factors in the prediction of the two indicators, with attention to sex-specific effects. Analyses were of 112 151 participants (58 914 females; 40 to 73 years) whose genetic data passed quality control. Moderation...
Published on May 14, 2019in Nature Communications 11.88
Philip J. Law10
Estimated H-index: 10
(ICR: Institute of Cancer Research),
Maria Timofeeva12
Estimated H-index: 12
(Medical Research Council)
+ 95 AuthorsVictoria Svinti (Medical Research Council)
Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene e...
Published on May 1, 2019in Nature Communications 11.88
Gail Davies46
Estimated H-index: 46
(Edin.: University of Edinburgh),
Max Lam11
Estimated H-index: 11
+ 219 AuthorsStuart J. Ritchie23
Estimated H-index: 23
(Edin.: University of Edinburgh)
Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
Published on May 1, 2019in Nature Communications 11.88
Yanni Zeng4
Estimated H-index: 4
(Edin.: University of Edinburgh),
Yanni Zeng2
Estimated H-index: 2
(Edin.: University of Edinburgh)
+ 20 AuthorsAndrew Bretherick4
Estimated H-index: 4
(Edin.: University of Edinburgh)
In the original version of this Article, the legend in the upper panel of Figure 2 incorrectly read ‘paternal imprinting’ and should have read ‘maternal imprinting’. This has been corrected in both the PDF and HTML versions of the Article.
Published on Jan 22, 2019in Nature Communications 11.88
Tuomas O. Kilpelaeinen31
Estimated H-index: 31
(ISMMS: Icahn School of Medicine at Mount Sinai),
Amy R. Bentley15
Estimated H-index: 15
(NIH: National Institutes of Health)
+ 234 AuthorsIoanna Ntalla27
Estimated H-index: 27
(QMUL: Queen Mary University of London)
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
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