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Mojca Strazisar
University of Antwerp
15Publications
7H-index
171Citations
Publications 15
Newest
Published on Jun 11, 2019in Genome Research 9.94
Wouter De Coster3
Estimated H-index: 3
,
Peter De Rijk28
Estimated H-index: 28
+ 5 AuthorsC. Van Broeckhoven109
Estimated H-index: 109
Published on Jun 1, 2019in Acta Neuropathologica 18.17
Rita Cacace4
Estimated H-index: 4
(University of Antwerp),
Bavo Heeman5
Estimated H-index: 5
(University of Antwerp)
+ 26 AuthorsMojca Strazisar7
Estimated H-index: 7
(University of Antwerp)
Emerging evidence suggested a converging mechanism in neurodegenerative brain diseases (NBD) involving early neuronal network dysfunctions and alterations in the homeostasis of neuronal firing as culprits of neurodegeneration. In this study, we used paired-end short-read and direct long-read whole genome sequencing to investigate an unresolved autosomal dominant dementia family significantly linked to 7q36. We identified and validated a chromosomal inversion of ca. 4 Mb, segregating on the disea...
Published on Nov 15, 2018in bioRxiv
Arne De Roeck4
Estimated H-index: 4
(University of Antwerp),
Wouter De Coster3
Estimated H-index: 3
(University of Antwerp)
+ 8 AuthorsC. Van Broeckhoven109
Estimated H-index: 109
(University of Antwerp)
Tandem repeats (TRs) can cause disease through their length, sequence motif interruptions, and nucleotide modifications. For many TRs, however, these features are very difficult - if not impossible - to assess, requiring low-throughput and labor-intensive assays. One example is a VNTR in ABCA7 for which we recently discovered that expanded alleles strongly increase risk of Alzheimer′s disease. Here, we investigated the potential of long-read whole genome sequencing to surmount these challenges, ...
Published on Oct 20, 2018in F1000Research
Wouter De Coster3
Estimated H-index: 3
,
Arne De Roeck4
Estimated H-index: 4
+ 5 AuthorsC. Van Broeckhoven109
Estimated H-index: 109
Published on Oct 3, 2018in bioRxiv
Wouter De Coster3
Estimated H-index: 3
,
Arne De Roeck4
Estimated H-index: 4
+ 5 AuthorsC. Van Broeckhoven109
Estimated H-index: 109
We sequenced the Yoruban NA19240 genome on the Oxford Nanopore PromethION for benchmarking and evaluation of recently published aligners and structural variant calling tools. In this work, we determined the precision and recall, present high confidence and high sensitivity call sets of variants and discuss optimal parameters. The aligner Minimap2 and structural variant caller Sniffles are both the most accurate and the most computationally efficient tools in our study. We describe our scalable w...
Published on May 27, 2018in F1000Research
Wouter De Coster3
Estimated H-index: 3
,
Tim De Pooter13
Estimated H-index: 13
+ 5 AuthorsC. Van Broeckhoven109
Estimated H-index: 109
Published on Mar 12, 2018in F1000Research
Wouter De Coster3
Estimated H-index: 3
,
Arne De Roeck4
Estimated H-index: 4
+ 5 AuthorsC. Van Broeckhoven109
Estimated H-index: 109
Published on Feb 18, 2016in Nucleic Acids Research 11.15
Sophia Cammaerts6
Estimated H-index: 6
(University of Antwerp),
Mojca Strazisar7
Estimated H-index: 7
(University of Antwerp)
+ 2 AuthorsPeter De Rijk28
Estimated H-index: 28
(University of Antwerp)
Genetic variants in or near miRNA genes can have profound effects on miRNA expression and targeting. As user-friendly software for the impact prediction of miRNA variants on a large scale is still lacking, we created a tool called miRVaS. miRVaS automates this prediction by annotating the location of the variant relative to functional regions within the miRNA hairpin (seed, mature, loop, hairpin arm, flanks) and by annotating all predicted structural changes within the miRNA due to the variant. ...
Published on Dec 29, 2015in PLOS ONE 2.78
Sophia Cammaerts6
Estimated H-index: 6
(University of Antwerp),
Mojca Strazisar7
Estimated H-index: 7
(University of Antwerp)
+ 6 AuthorsJurgen Del Favero11
Estimated H-index: 11
(University of Antwerp)
As regulators of gene expression, microRNAs (miRNAs) are likely to play an important role in the development of disease. In this study we present a large-scale strategy to identify miRNAs with a role in the regulation of neuronal processes. Thereby we found variant rs7861254 located near the MIR204 gene to be significantly associated with schizophrenia. This variant resulted in reduced expression of miR-204 in neuronal-like SH-SY5Y cells. Analysis of the consequences of the altered miR-204 expre...
Published on Apr 1, 2015in Molecular Psychiatry 11.97
Mojca Strazisar7
Estimated H-index: 7
,
Sophia Cammaerts6
Estimated H-index: 6
+ 11 AuthorsAnthony M. L. Liekens8
Estimated H-index: 8
Sequence analysis of 13 microRNA (miRNA) genes expressed in the human brain and located in genomic regions associated with schizophrenia and/or bipolar disorder, in a northern Swedish patient/control population, resulted in the discovery of two functional variants in the MIR137 gene. On the basis of their location and the allele frequency differences between patients and controls, we explored the hypothesis that the discovered variants impact the expression of the mature miRNA and consequently i...
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