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Oxana Musatovova
University of Texas Health Science Center at San Antonio
15Publications
12H-index
413Citations
Publications 15
Newest
Published on Oct 16, 2012in PLOS ONE 2.78
Oxana Musatovova12
Estimated H-index: 12
(University of Texas Health Science Center at San Antonio),
Thirumalai R. Kannan20
Estimated H-index: 20
(University of Texas Health Science Center at San Antonio),
Joel B. Baseman36
Estimated H-index: 36
(University of Texas Health Science Center at San Antonio)
Mycoplasma pneumoniae is the smallest self-replicating bacterium with a streamlined genome of 0.81 Mb. Complete genome analysis revealed the presence of multiple copies of four large repetitive elements (designated RepMP1, RepMP2/3, RepMP4 and RepMP5) that are implicated in creating sequence variations among individual strains. Recently, we described RepMP1-associated sequence variations between reference strain M129 and clinical isolate S1 that involved three RepMP1-genes (i.e. mpn130, mpn137 a...
Published on Jan 15, 2012in Clinical Infectious Diseases 9.05
Thirumalai R. Kannan20
Estimated H-index: 20
,
Robert D. Hardy14
Estimated H-index: 14
(UTSW: University of Texas Southwestern Medical Center)
+ 6 AuthorsJoel B. Baseman36
Estimated H-index: 36
Mycoplasma pneumoniae is an atypical bacterial pathogen without a cell wall that affects both the upper and lower respiratory tracts of children and adults. It is implicated in airway diseases including pneumonia, exacerbation of wheezing, tracheobronchitis, and pharyngitis, as well as extrapulmonary manifestations such as neurological, hematologic, gastrointestinal, and dermatological pathologies [1, 2]. Among M. pneumoniae–infected patients, it is estimated that 3%–10% develop clinical pneumon...
Published on Nov 15, 2011in The Journal of Infectious Diseases 5.04
Thirumalai R. Kannan20
Estimated H-index: 20
,
Jacqueline J. Coalson26
Estimated H-index: 26
(University of Texas at Austin)
+ 3 AuthorsJoel B. Baseman36
Estimated H-index: 36
Mice were infected with Mycoplasma pneumoniae and monitored for the synthesis and distribution of the unique adenosine diphosphate–ribosylating and vacuolating Community Acquired Respiratory Distress Syndrome (CARDS) toxin in bronchiolar lavage fluid (BALF) and lung. We noted direct relationships between the concentration of CARDS toxin and numbers of mycoplasma genomes in BALF and the degree of histologic pulmonary inflammation. Immunostaining of lungs revealed extensive colonization by mycopla...
Published on Oct 1, 2010in Chest 9.66
Jay I. Peters32
Estimated H-index: 32
,
Harjinder Singh4
Estimated H-index: 4
+ 4 AuthorsJoel B. Baseman36
Estimated H-index: 36
Published on Mar 1, 2010in International Journal of Std & Aids 1.50
Andrea Ries Thurman14
Estimated H-index: 14
(EVMS: Eastern Virginia Medical School),
Oxana Musatovova12
Estimated H-index: 12
(University of Texas Health Science Center at San Antonio)
+ 3 AuthorsJoel B. Baseman36
Estimated H-index: 36
The objective of this study was to determine the prevalence and concordance of Mycoplasma genitalium (MG) among Mexican American and African American women and their male sexual partners. Secondary objectives were to determine symptoms of MG infection and persistence of MG after antibiotic therapy. Heterosexual couples were tested for MG and interviewed separately regarding symptoms and behavioural/epidemiologic variables at baseline, six and 12 months. The overall prevalence of MG among women a...
Published on Feb 28, 2010in Molecular Microbiology 3.65
Thirumalai R. Kannan20
Estimated H-index: 20
,
Oxana Musatovova12
Estimated H-index: 12
(UTSA: University of Texas at San Antonio)
+ 6 AuthorsJoel B. Baseman36
Estimated H-index: 36
Summary Mycoplasma pneumoniae causes acute and chronic respiratory infections, including tracheobronchitis and community acquired pneumonia, and is linked to asthma and an array of extra-pulmonary disorders. Recently, we identified an ADP-ribosylating and vacuolating toxin of M. pneumoniae, designated Community Acquired Respiratory Distress Syndrome (CARDS) toxin. In this study we analysed CARDS toxin gene (annotated mpn372) transcription and identified its promoter. We also compared CARDS toxin...
Published on May 1, 2009in Journal of Clinical Microbiology 4.96
Oxana Musatovova12
Estimated H-index: 12
(University of Texas Health Science Center at San Antonio),
Joel B. Baseman36
Estimated H-index: 36
Mycoplasma genitalium is a human bacterial pathogen linked to urethritis and other sexually transmitted diseases. Here, we assessed the incidence of M. genitalium infection in patients attending a sexually transmitted disease clinic in San Antonio, TX, by use of diagnostic real-time PCR. Overall, 16.8% of women and 15.1% of men were found M. genitalium positive. Regions of the mgpB gene, which encodes the MgPa adhesin, were amplified from positive clinical specimens and evaluated for sequence va...
Published on Nov 1, 2008in Infection and Immunity 3.16
Thirumalai R. Kannan20
Estimated H-index: 20
,
Oxana Musatovova12
Estimated H-index: 12
(University of Texas Health Science Center at San Antonio)
+ 1 AuthorsJoel B. Baseman36
Estimated H-index: 36
Mycoplasma pneumoniae accounts for 20 to 30% of all community-acquired pneumonia and has been associated with other airway pathologies, including asthma, and a range of extrapulmonary manifestations. Although the entire genomic sequence of M. pneumoniae has been completed, the functions of many of these genes in mycoplasma physiology are unknown. In this study, we focused on clpB, a well-known heat shock gene in other bacteria, to examine its role in mycoplasma growth. Transcriptional and transl...
Published on Apr 1, 2008in Infection and Immunity 3.16
Oxana Musatovova12
Estimated H-index: 12
(University of Texas Health Science Center at San Antonio),
Thirumalai R. Kannan20
Estimated H-index: 20
,
Joel B. Baseman36
Estimated H-index: 36
Mycoplasmas are cell wall-less bacteria that evolved by drastic reduction of the genome size. Complete genome analysis of Mycoplasma pneumoniae revealed the presence of numerous copies of four distinct large M. pneumoniae repetitive elements (RepMPs). One copy each of RepMP2/3, RepMP4, and RepMP5 are localized within the P1 operon (MPN140 to MPN142 loci), and their involvement in sequence variation in adhesin P1 and adherence-related protein B/C has been documented. Here we analyzed a clinical s...
Published on Apr 15, 2006in Journal of Bacteriology 3.23
Oxana Musatovova12
Estimated H-index: 12
(University of Texas Health Science Center at San Antonio),
S. Dhandayuthapani9
Estimated H-index: 9
(University of Texas Health Science Center at San Antonio),
Joel B. Baseman36
Estimated H-index: 36
Mycoplasma genitalium is a human bacterial pathogen linked to urethritis and other sexually transmitted diseases as well as respiratory and joint pathologies. Though its complete genome sequence is available, little is understood about the regulation of gene expression in this smallest known, self-replicating cell, as its genome lacks orthologues for most of the conventional bacterial regulators. Still, the transcriptional repressor HrcA (heat regulation at CIRCE [controlling inverted repeat of ...
12