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Gene G. Hunder
Mayo Clinic
PathologyVasculitisGiant cell arteritisPolymyalgia rheumaticaMedicine
272Publications
76H-index
48.6kCitations
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Publications 271
Newest
#1Carlo SalvaraniH-Index: 73
#2Robert D. Brown (Mayo Clinic)H-Index: 74
Last. Gene G. Hunder (Mayo Clinic)H-Index: 76
view all 6 authors...
Abstract Objectives To evaluate long-term treatment and outcomes of patients with primary central nervous system vasculitis (PCNSV). Methods In this cohort of 191 consecutive patients with PCNSV seen at Mayo Clinic, Rochester, MN, over 35 years with long-term follow-up we analyzed response to and duration of therapy, frequency of relapses, long-term remission, efficacy of maintenance therapy and initial intravenous glucocorticoid (GC) pulses, survival and degree of disability. We also compared t...
1 CitationsSource
Abstract Concentrations of whole hemolytic complement, three components (C1q, C4, C3), and C1INH were lower in the pericardial fluids of two patients with systemic lupus erythematosus with pericard...
#1Gene G. HunderH-Index: 76
#2Sheldon G. ShepsH-Index: 3
Last. John W. JoyceH-Index: 1
view all 4 authors...
Abstract Alternate-day corticosteroid therapy was compared with two daily corticosteroid regimens for the treatment of giant cell arteritis. In a prospective study 60 patients with this disease wer...
#1Sharad LakhanpalH-Index: 11
#2William W. GinsburgH-Index: 15
Last. Gene G. HunderH-Index: 76
view all 4 authors...
Abstract We describe the clinical features and course of disease in 56 patients (33 men and 23 women) with transient regional osteoporosis. The median age at hospitalization was 48 years. All patie...
#1Eelco F. M. Wijdicks (Mayo Clinic)H-Index: 79
#2Thomas W. Rooke (Mayo Clinic)H-Index: 1
Last. Matthew D. Dacy (Mayo Clinic)H-Index: 2
view all 4 authors...
Abstract In this article, the authors offer a new perspective on how the administration of Compound E (ie, cortisone) to a volunteer Mayo Clinic patient with rheumatoid arthritis and the patient’s subsequent miraculous improvement led not only to a major, successful clinical trial but also a Nobel Prize. The early and late side effects as an undesirable outcome of treatment of corticosteroids would soon follow. Corticosteroid side effects became known in popular culture, first through an indepth...
Source
#1Carlo SalvaraniH-Index: 73
#2Robert D. Brown (Mayo Clinic)H-Index: 74
Last. Gene G. Hunder (Mayo Clinic)H-Index: 76
view all 11 authors...
Abstract Objectives To assess the efficacy and safety of Rituximab (RTX) in adult primary central nervous system vasculitis (PCNSV). Methods We retrospectively assessed the effect of RTX in 6 patients with PCNSV. Five of the 6 were refractory to high dose glucocorticoids (GCs) and/or conventional immunosuppressants (IS). The sixth was newly diagnosed and received RTX in combination with GCs. Clinical evaluation, laboratory tests, and imaging modalities were performed at initial RTX administratio...
Source
#1Carlo Salvarani (Mayo Clinic)H-Index: 73
#2Robert D. Brown (Mayo Clinic)H-Index: 74
Last. Gene G. Hunder (Mayo Clinic)H-Index: 76
view all 7 authors...
Abstract Objective To describe the clinical, laboratory, and imaging features and course of patients with primary central nervous system vasculitis (PCNSV) presenting with an intracranial tumor-like mass (TLM). Methods We retrospectively studied a cohort of 191 consecutive patients with PCNSV seen at the Mayo Clinic, Rochester, MN over a 35-year period (1982–2017). 13/191 patients presented with a TLM. We compared the findings in these 13 patients with those from the 178 without this presentatio...
1 CitationsSource
#1Carlo SalvaraniH-Index: 73
#2Robert D. Brown (Mayo Clinic)H-Index: 74
Last. Gene G. Hunder (Mayo Clinic)H-Index: 76
view all 6 authors...
Background Primary central nervous system vasculitis (PCNSV) rarely presents as a tumor-like mass lesion (ML). Objectives The aim of this study was to determine the frequency of ML in a large cohort of patients with PCNSV and compare the presenting clinical, laboratory, and imaging features in those with ML to those without. Methods We retrospectively studied a cohort of 191 consecutive patients with PCNSV who were seen at the Mayo Clinic, Rochester, MN over a 35 year period. The diagnosis of PC...
Source
#1Carlo Salvarani (Mayo Clinic)H-Index: 73
#2Robert D. Brown (Mayo Clinic)H-Index: 74
Last. Gene G. Hunder (Mayo Clinic)H-Index: 76
view all 7 authors...
Objectives To record the clinical findings, response to therapy, and course of patients with primary CNS vasculitis (PCNSV) associated with lymphoma. Patients and Methods We reviewed the histories of 936 patients with a diagnosis of any type of vasculitis and lymphoma who were seen at the Mayo Clinic over a 32-year period. Ten patients with both PCNSV and lymphoma were identified. We compared the findings in these 10 patients with those from 158 patients with PCNSV without lymphoma seen over 29 ...
2 CitationsSource
#1Joseph J. Maleszewski (Mayo Clinic)H-Index: 33
#2Brian R. Younge (Mayo Clinic)H-Index: 32
Last. Cornelia M. Weyand (Stanford University)H-Index: 101
view all 7 authors...
Although clinical signs and symptoms of giant cell arteritis improve promptly after starting glucocorticoid therapy, reports have suggested that the vascular inflammation may persist. To assess the duration and quality of histopathologic changes in treated patients, we prospectively obtained second temporal artery biopsies in patients treated for 3 to 12 months after their first diagnostic biopsy. Forty patients (28 women, 12 men, median age 77 years) agreed to have a second temporal artery biop...
33 CitationsSource
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