Georg Gosztonyi
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Publications 27
#1Georg Gosztonyi (Charité)H-Index: 12
#2Kerstin Borchers (FU: Free University of Berlin)H-Index: 20
Last. Hanns Ludwig (FU: Free University of Berlin)H-Index: 40
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Equine herpesvirus-1 (EHV-1) is a major equine pathogen causing respiratory diseases, abortions and severe neurological disorders. The basis of neurological disturbances is, as in other organs, infection of endothelial cells, followed by vasculitis, thrombosis and ischaemic damage of the parenchyma. Here, a murine model was used to explore the mechanism of entry to, and spread within the brain, the cell affinity of the agent and the modulating role of the immune defence, which are all factors go...
13 CitationsSource
17 CitationsSource
#1Sabine Wagner (University of Regensburg)H-Index: 13
Last. Laszlo K. CsataryH-Index: 10
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The case of a 12-year-old boy with anaplastic astrocytoma of the left thalamus is reported. Postoperative irradiation and chemotherapy could not repress tumor progression; therefore, treatment was undertaken with an oncolytic virus, MTH-68/H, an attenuated strain of Newcastle disease virus (NDV), and valproic acid (VPA), an antiepileptic drug, which also has antineoplastic properties. This treatment resulted in a far-reaching regression of the thalamic glioma, but 4 months later a new tumor mani...
33 CitationsSource
#1Georg Gosztonyi (FU: Free University of Berlin)H-Index: 12
#2Felicia SlowikH-Index: 9
Last. Emil PásztorH-Index: 15
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Five patients are reported who underwent X-ray epilation in childhood for tinea capitis and who developed meningiomas after about four decades. X-ray irradiation resulted in permanent alopecia in four of the five patients. In four patients the tumors were found on the convexity, one patient had a tuberculum sellae meningioma. All five patients underwent surgery. Recurrence was noted in three of the five patients, one of them was reoperated. No malignant features, but signs of atypia were found a...
11 CitationsSource
#1Laszlo K. CsataryH-Index: 10
#2Georg Gosztonyi (FU: Free University of Berlin)H-Index: 12
Last. Christine M. CsataryH-Index: 5
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Application of virus therapy to treat human neoplasms has over a three decade history. MTH-68/H, a live attenuated oncolytic viral strain of the Newcastle disease virus, is one of the viruses used in the treatment of different malignancies. Here we report on the administration of MTH-68/H to patients with glioblastoma multiforme, the most common and most aggressive neuroectodermal neoplasm with a poor prognosis, averaging six months to a year. Four cases of advanced high-grade glioma were treate...
122 CitationsSource
#1Georg Gosztonyi (FU: Free University of Berlin)H-Index: 12
#2Ulrich Naschold (FU: Free University of Berlin)H-Index: 1
Last. Reinhart Gossrau (FU: Free University of Berlin)H-Index: 24
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Neural cell adhesion molecule (N-CAM, Leu-19, CD 56) expression appears during muscle fiber regeneration and after denervation. Sarcolemma-associated nitric oxide synthase (NOS) I, however, disappears from denervated myofibers. The dynamics of expression of both proteins were studied in 5 cases of acute/subacute denervation, 28 cases of chronic denervation with and without collateral reinnervation, 5 cases of the intermediate type spinal muscular atrophy (SMA 2), and in 2 normal biopsies. NOS I ...
30 CitationsSource
: An experimental investigation was performed to examine the influence of ACTH on the long-term results of muscle regeneration after nerve repair. Twenty albino-rabbits ("White Russians") served as the animal model. The epi-perineural neurorrhaphy of the fibular nerve was carried out under microscopic control with 11x0 sutures. A computer-supported light-microscopic analysis of representative muscle-fiber diameters was performed for detection of nerve regeneration on the effector muscle of the p...
#1Zarko GrozdanovicH-Index: 16
#2Tatjana ChristovaH-Index: 5
Last. Reinhart GossrauH-Index: 24
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Recently, it has been shown that in human striated muscle the signalling enzyme, brain-type nitric oxide synthase I (NOS I), is associated with the sarcolemma and complexes with dystrophin and/or members of the dystrophin complex. In order to find out whether there exists a regular association between NOS I and the complex, muscle biopsies from patients with various muscle disorders were analysed by enzyme histochemistry and immunohistochemistry. In patients suffering from Duchenne muscular dyst...
24 CitationsSource